Selank Nasal 40mg/30ml

Selank 5mg (Freeze-Dried Peptide) – Exclusive for Research Use

Product details:

• Catalog #: SEL-5MG
• Physical State: Lyophilized (dry) powder
• Purity Level: 99% or higher (HPLC confirmed)
• Amount: 5mg total per vial
• Storage Protocol: Pre-reconstitution: -20°C / Post-reconstitution: 2-8°C
• Transport: Ships at ambient temperature with cold packs (sensitive to heat)

Key research applications:

• Examination of anxiolytic effects absent of sedative property
• Investigations into memory consolidation and cognitive enhancement
• Analysis of neurotransmitter balance (serotonin, norepinephrine, dopamine)
• Researching regulation of cytokines and neuroinflammatory responses
• Studies involving immunotropic pathways

Handling Preparation:

• Use sterile bacteriostatic water for reconstitution. Move vial in a gentle swirl—avoid vortexing. Divide into aliquots to prevent damage from repeated freeze-thaw events.

Important Note:

• PX1 Research provides this material solely for animal and in vitro experimentation. It is not intended for human consumption, therapeutic use, or medical diagnosis. Handling should be restricted to trained personnel wearing proper PPE.

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Overview

Selank is a synthetic version of a heptapeptide (consisting of the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro) that shares structural similarities with the naturally occurring immunomodulatory peptide known as tuftsin. Created originally by the Russian Academy of Sciences' Institute of Molecular Genetics, Selank has undergone extensive preclinical and clinical scrutiny regarding its impact on anxiety-related behaviors, mental performance, neuroinflammation, and various neurotransmitter systems.

The provided 5mg lyophilized format is designated solely for in vivo and in vitro research protocols, such as receptor affinity trials, cellular assays, analytical validation, and animal studies. This substance is strictly prohibited for use in veterinary or human clinical settings outside of a controlled lab environment.

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Chemical & Physical Properties

• Molecular Formula: C₃₃H₅₇N₁₁O₉
• Molecular Mass: 751.87 g/mol
• Primary Sequence: H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH (available as acetate salt depending on the lot)
• Physical Form: White or nearly white lyophilized powder/cake
• Solubility Profile: Readily dissolves in sterile water (0.9% NaCl is advised), bacteriostatic water, or PBS (pH 5–6). Do not shake aggressively.
• Stability: Remains stable when maintained under specified temperatures. Post-reconstitution, avoid multiple cycles of freezing and thawing.

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Primary Research Applications

Researchers utilize Selank in rigorous laboratory environments to explore these specific pathways and outcomes:

1. Non-Sedative Anxiolytic Properties

In contrast to conventional benzodiazepines, Selank research models do not indicate motor impairment, amnesia, or muscle-relaxing side effects. In tests such as the open field or elevated plus-maze, investigators have seen reductions in anxiety markers that correlate with the dosage, hinting at an interaction with the GABAergic system through a unique, non-benzodiazepine mechanism.

2. Nootropic Effects and Cognitive Research

Scientific trials using rodent subjects have shown enhanced memory storage and faster learning acquisition in models of stress-induced cognitive decline or scopolamine-induced memory loss. Data suggests Selank may influence the expression of brain-derived neurotrophic factor (BDNF) and support neurogenesis within the hippocampus during periods of stress.

3. Regulation of Neuroinflammation

Due to its tuftsin-derived structure, Selank possesses immunotropic characteristics. Scientific literature suggests it may lower levels of pro-inflammatory cytokines such as IL-6, IL-1β, and TNF-α, while boosting the anti-inflammatory cytokine IL-10 in the nervous system. This makes it a subject of interest for pain, trauma, and chronic stress research.

4. Neurotransmitter Balancing

Through the use of tissue analysis and microdialysis, studies show that Selank can modify the extracellular concentrations of dopamine (DA), serotonin (5-HT), and norepinephrine (NE) within the hippocampus and prefrontal cortex. These region-specific, dose-reliant changes provide a foundation for studying its internal mechanics.

5. Immune and Viral Research (In Vitro)

Because of its homology to tuftsin, Selank has been studied for its capacity to regulate interferon-gamma (IFN-γ) and various antiviral signaling components in immune cell cultures. While these applications are still being mapped, they are heavily documented in immunology journals.

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Quality Assurance & Testing

PX1 Research subjects every batch of Selank 5mg to strict quality verification:

• HPLC Analysis: ≥99% Purity (test results available by request)
• Mass Spec (MS): Molecular weight verification within ±0.05% of target
• Residual Solvents: Compliant with ICH Q3C standards
• Endotoxin Levels: Below 1.0 EU/mg via LAL testing
• Sterile Processing: 0.22µm filtration applied before lyophilization

A Certificate of Analysis (CoA) is included with every order.

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Reconstitution & Handling Protocol (For Laboratory Use Only)

1. Acclimatize the vial: Let it reach room temperature before unsealing to prevent moisture buildup.
2. Dilution: Introduce 1–2 mL of 0.9% saline or sterile bacteriostatic water to the powder.
3. Gentle Mixing: Swirl the vial lightly; never shake or vortex, as this can degrade the peptide structure.
4. Final Check: Wait 1–3 minutes for complete dissolution. The liquid must be transparent and free of sediment.
5. Storage: Use aliquots to prevent freezing and thawing the same sample repeatedly. Keep at 2–8°C for a maximum of 30 days, or freeze at -20°C for extended use.

Standard Research Dosages (Animal Subjects): Typical ranges fall between 0.1 – 1.0 mg/kg via subcutaneous (SC) or intraperitoneal (IP) delivery. Proper dosage and routes must be established by the Lead Researcher.

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Safety & Legal Disclaimer

⚠️ STRICTLY FOR RESEARCH USE. NOT INTENDED FOR VETERINARY OR HUMAN CONSUMPTION.

• This substance is not categorized as a food, drug, supplement, or medicine.
• It is not for recreational, diagnostic, or therapeutic purposes.
• Not cleared by the MHRA, EMA, FDA, or other health authorities for human use.
• Restricted to use by qualified scientists in appropriate lab facilities.
• Under no circumstances should this be given to humans or pets.
• Handle only with necessary personal protective equipment (PPE), including eye protection, lab coats, and gloves.

Purchase of this product confirms you are a minimum of 18 years old and intend to use Selank 5mg solely for legitimate scientific research.

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References (Selected Peer-Reviewed Literature)

1. Volkova, A. V., et al. (2016). Neuroscience and Behavioral Physiology, 46(3), 273–278.
2. Kolik, L. G., et al. (2014). Bulletin of Experimental Biology and Medicine, 157(3), 351–354.
3. Zozulya, A. A., et al. (2008). Bulletin of Experimental Biology and Medicine, 145(3), 340–343.
4. Uchakina, O. N., et al. (2014). Pharmaceutical Chemistry Journal, 48(1), 10–13.

Extended bibliographies are available on request.

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