Alpha-Klotho (α-Klotho LR)
α-Klotho LR
Research-Grade Peptide · 99%+ Purity · COA Certified
Made in the USA
Ships from the USA
Research-Grade Peptide · 99%+ Purity · COA Certified
α-Klotho LR
Also searched as alpha klotho, klotho, klotho peptide, buy klotho, a-klotho.
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For research use only. Not for human or animal consumption.
Certificate of Analysis
Independently 8× tested by ILS Laboratories and/or Kovera Labs.
99.38%
Purity
Passed full QC panel
Full QC panel
8× tested
ISO/IEC 17025 Accredited
All certificates are issued by independent ISO-accredited laboratories. Lot-specific documents are made available to qualified research professionals on request.
Full GHS 16-section Safety Data Sheet for Alpha-Klotho, prepared per OSHA HazCom 2012 (29 CFR 1910.1200). Includes substance identity, handling & storage, PPE, stability, transport and regulatory information.
CAS No.
Not assigned
Formula
Not assigned
Mol. Weight
Per COA
Classification
Not hazardous (GHS)
α-Klotho LR — Research-Grade Klotho Protein for In Vitro Studies
alphaKlothoLR is a patented, long-release version of the recombinant Klotho protein, containing specific amino acid sequences, linkers, and an albumin binding group that allows for sustained delivery of Klotho with cellular activity up to 19 days.
This research-grade construct combines α-Klotho protein with a proprietary 29-amino acid albumin binding peptide (GGSGGSGGSGGRLIEDICLPRWGCLWEDD). The modification enables strong albumin binding affinity (<20 nM) while maintaining native FGF23 binding activity (15-30 nM).
Produced through recombinant expression with rigorous third-party testing. Each batch includes HPLC and LC-MS verification to confirm molecular identity and purity standards. Complete analytical documentation supports laboratory applications investigating protein-albumin interactions, FGF23 signaling pathways, and albumin binding mechanisms.
For in vitro research use only.
Klotho Protein Information
| Property | Value |
|---|---|
| Peptide Sequence | α-Klotho protein (1012 amino acids) + albumin binding construct: GGSGGSGGSGGRLIEDICLPRWGCLWEDD |
| Molecular Weight | ~133-135 kDa (full construct with albumin binder) |
| Albumin Binding Affinity (Kd) | <20 nM |
| FGF23 Binding Affinity (Kd) | 15-30 nM (optimized: 16.2 nM) |
| Synonyms | α-Klotho-albumin binding construct, Modified Klotho with glycine-serine linker |
Lyophilized Peptides
These peptides are freeze-dried, a process that not only extends shelf life but also preserves the purity and integrity of the peptides during storage. We do not use any fillers in this process.
Product Usage
THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug.
This product is for laboratory research purposes only. Not for human or animal consumption.
Purity (HPLC)
≥99%
Application
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Testing
Third Party Tested
Manufacture
USA
99%+ HPLC Purity
Independently verified by accredited US laboratory
Endotoxin-Screened
LAL tested, LPS-free, endotoxin report available
GMP-Certified Manufacturing
USA facility, ISO 9001:2015
Lyophilized for Stability
Shipped cold-packed, intact for reconstitution
Supplied as a research-grade compound for in-vitro and laboratory investigation.
For research use only — not for human or animal consumption.
Reconstitute
Reconstitute with bacteriostatic water for safe, accurate solvation before assay preparation.
Store Properly
Refrigerate the reconstituted solution at 2–8°C and use within 30 days for best stability.
Document Research
Log batch number, concentration and research notes per your laboratory protocol.
High Quality — 99% Purity Guaranteed
Product Quality Guarantee
We are continuously conducting HPLC testing on all of our raw powders as well as our finished products to ensure the quality of what we ship. You can have the product you bought from us independently tested at any HPLC-licensed testing facility — and if the results come back negative, we will refund the following:
HPLC Test Fee
$100
Plus a full refund
Total order amount + shipping