PT-141 For Sale — Research Grade
PX1 Research supplies laboratory-grade PT-141 (Bremelanotide) synthesized in the United States and subject to rigorous ISO 17025 analytical verification. Every lot undergoes independent HPLC and Mass Spectrometry testing to guarantee sequence integrity and purity exceeding 99% for advanced preclinical investigations.
Quick answer
PX1 Research supplies laboratory-grade PT-141 (Bremelanotide) synthesized in the United States and subject to rigorous ISO 17025 analytical verification. Every lot undergoes independent HPLC and Mass Spectrometry testing to guarantee sequence integrity and purity exceeding 99% for advanced preclinical investigations.
Key takeaways
- [PT-141](/research-peptides/pt-141), chemically designated as Bremelanotide, is a synthetic cyclic heptapeptide analog derived from the naturally occurring alpha-melanocyte-stimulating hormone (α-MSH).
- [PT-141](/research-peptides/pt-141) acts primary as a non-selective melanocortin receptor agonist, exhibiting marked binding affinity for the MC3R and MC4R subtypes within the central nervous system, alongside secondary activation at MC1R and MC5R.
- Understanding the differences among melanocortin agonists is crucial when establishing controlled assay parameters.
- In vitro data indicate that [PT-141](/research-peptides/pt-141) provides a reliable baseline for evaluating GPCR ligand binding kinetics, receptor internalization rates, and downstream signal transduction.
PT-141 Overview and Structural Identity
PT-141, chemically designated as Bremelanotide, is a synthetic cyclic heptapeptide analog derived from the naturally occurring alpha-melanocyte-stimulating hormone (α-MSH). Structurally, its sequence is Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH, featuring a lactam bridge between the aspartic acid and lysine residues. This cyclic conformation confers enhanced enzymatic stability against baseline endopeptidases relative to linear endogenous melanocortin peptides, allowing investigators to maintain stable peptide concentrations during protracted in vitro assays and controlled animal model studies.
Researchers seeking pt-141 for sale frequently utilize this compound due to its distinct receptor affinity profile compared to ancestor molecules. By removing the C-terminal amino acid chain found in native α-MSH, PT-141 retains potent agonist activity across central nervous system melanocortin receptors without maintaining non-selective pigmentation properties to the same degree as earlier derivatives. When procuring our research-grade PT-141 10mg vial, investigators receive a highly purified lyophilized cake designed specifically for controlled reconstitution in experimental environments.
Mechanism of Action: Melanocortin Receptor Signaling Pathways
PT-141 acts primary as a non-selective melanocortin receptor agonist, exhibiting marked binding affinity for the MC3R and MC4R subtypes within the central nervous system, alongside secondary activation at MC1R and MC5R. Unlike classical peripheral vasoactive compounds that alter hemodynamics via direct nitric oxide donor mechanisms or phosphodiesterase-5 inhibition, PT-141 targets central neurochemical circuits located within the paraventricular nucleus (PVN) and medial preoptic area (mPOA) of the hypothalamus.
Preclinical studies suggest that stimulation of MC4R by synthetic agonists triggers intracellular cyclic adenosine monophosphate (cAMP) accumulation through G-protein coupled receptor (GPCR) cascades. This central activation subsequently downstream-modulates dopaminergic and noradrenergic pathways involved in motivational and appetitive behavior. Research models evaluating melanocortin-receptor signaling linked to sexual-health pathways demonstrate that central MC4R recruitment initiates descending autonomic signals to pelvic neurovascular structures, providing a unique central neurochemical target for experimental evaluation.
Comparative Analysis: PT-141, Melanotan II, and Native α-MSH
Understanding the differences among melanocortin agonists is crucial when establishing controlled assay parameters. While native alpha-MSH analogs possess extremely short biological half-lives due to rapid enzymatic degradation in plasma, synthetic derivatives incorporate D-amino acid substitutions and cyclization to resist cleavage.
When comparing PT-141 to Melanotan II, distinct functional divergences emerge in literature. Melanotan II features a prominent affinity for the MC1R subtype, which strongly promotes melanogenesis in epidermal melanocytes alongside central nervous system effects. In contrast, PT-141 is a metabolite analog engineered to diminish MC1R-driven pigmentation activity while preserving selective binding to central MC3R and MC4R pathways. In comparative models alongside central neuropeptides like oxytocin research peptides, PT-141 displays an independent neuroendocrine signaling pathway that operates upstream of peripheral autonomic output, making it an essential reference tool in neurobiology laboratories.
In Vitro and Preclinical Research Applications
In vitro data indicate that PT-141 provides a reliable baseline for evaluating GPCR ligand binding kinetics, receptor internalization rates, and downstream signal transduction. In recombinant cell lines expressing human MC4R, researchers utilize PT-141 to map agonist-induced beta-arrestin recruitment versus canonical G-protein signaling pathways, facilitating bias-factor calculations for novel melanocortin ligand design.
In vivo rodent models have extensively utilized PT-141 to explore the central control of consummatory, social, and reproductive behaviors. Studies investigating central melanocortin signaling demonstrate that ICV or systemic administration of PT-141 in rodent models increases c-Fos expression within specific hypothalamic nuclei. Furthermore, animal studies focused on neuroinflammation indicate that central MC4R stimulation by synthetic agonists may downregulate pro-inflammatory cytokine expression in activated microglia, opening broader avenues of investigation beyond behavioral neurobiology.
Quality Assurance, Purity Standards, and Lot Testing
The scientific validity of any preclinical experiment depends entirely on the chemical purity and structural integrity of the reagents utilized. PX1 Research implements an uncompromising quality assurance standard for all compounds offered for sale. Every lot of PT-141 is synthesized within state-of-the-art facilities in the United States operating under strict quality management systems.
Following synthesis and purification via preparative High-Performance Liquid Chromatography (HPLC), representative samples from each production lot undergo rigorous third-party analytical verification at an independent ISO 17025 accredited laboratory. Analytical testing encompasses single-run HPLC purity determination—ensuring peptide purity meets or exceeds 99.0%—and Electrospray Ionization Mass Spectrometry (ESI-MS) to verify exact molecular weight matching theoretical values (1024.2 g/mol). Furthermore, endotoxin levels are verified using chromogenic Limulus Amebocyte Lysate (LAL) assays to ensure levels remain well below published threshold limits, mitigating confounding inflammatory responses during in vitro cell culture studies.
Reconstitution and Handling Protocol for Laboratory Setting
PT-141 is supplied as a sterile, lyophilized cake inside sealed borosilicate glass vials to ensure long-term stability during transport and storage. Upon receipt, lyophilized peptide vials should be stored in a controlled freezer environment at -20°C or -80°C, protected from light and moisture.
For laboratory experimental preparation, proper peptide reconstitution procedures must be strictly observed. Reconstitution should occur using sterile Bacteriostatic Water (0.9% benzyl alcohol) or sterile endotoxin-free phosphate-buffered saline (PBS), depending on the requirements of the biological assay. To avoid shearing the secondary structure of the peptide, the solvent stream should be directed against the glass wall of the vial, followed by gentle swirl agitation until complete dissolution is observed. Reconstituted solution aliquots should be used immediately or stored at 4°C for short-term experimentation to avoid freeze-thaw degradation cycles.
PX1 Research Technical Specifications & Specifications Summary
When purchasing pt-141 for sale, research institutions require full transparency regarding material physical properties and analytical data. PX1 Research maintains complete batch records and Certificate of Analysis (COA) documentation accessible for every customer shipment.
Key chemical parameters for PX1 Research PT-141 include: IUPAC Name: cyclo(1->6)-Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-OH; Molecular Formula: C50H68N14O10; Molecular Mass: 1024.18 Da; CAS Registry Number: 189691-06-3; Purity (HPLC): ≥99.0%; Appearance: White to off-white lyophilized powder; Form: Acetate salt. To review comprehensive spectral reports or cross-reference lot details, researchers are encouraged to consult our centralized PX1 research repository.
Logistics, Packaging, and Same-Day Fulfillment
Recognizing that research schedules require rapid, reliable delivery, PX1 Research maintains dual dispatch operations out of California and Arizona. Orders placed before cut-off deadlines Monday through Friday are processed and shipped same-day via expedited carrier services.
Every shipment containing research peptides is packaged using temperature-stable cold-chain insulation techniques designed to protect lyophilized proteins from thermal stress during transit. Vials are secured in shock-resistant internal casing to prevent structural compromise. Tracking details and chain-of-custody updates are provided automatically upon shipment creation.
Institutional Accounts and Wholesale Procurement
PX1 Research provides dedicated supply services for academic institutions, contract research organizations (CROs), and biotechnology firms requiring consistent bulk quantities of analytical-grade peptides. Through our wholesale procurement portal, institutional buyers can establish recurring batch shipments, request custom lot sizes, and lock in guaranteed lot availability.
Bulk orders are accompanied by complete analytical verification dossiers, including high-resolution HPLC chromatograms, mass spectrum readouts, and batch-specific endotoxin test records. Our technical support team works directly with laboratory managers to fulfill specific quality control protocols and documentation compliance standards required for university or institutional research setups.
Frequently Asked Questions
What is the certified purity level of PT-141 sold by PX1 Research?
PX1 Research guarantees that all PT-141 lots meet or exceed 99.0% purity as determined by High-Performance Liquid Chromatography (HPLC) testing performed by an independent ISO 17025 accredited laboratory.
How is PT-141 verified for mass and identity?
Every batch undergoes Electrospray Ionization Mass Spectrometry (ESI-MS) to confirm the exact theoretical molecular weight of 1024.18 Da, confirming sequence identity and structural integrity prior to packaging.
Is PT-141 tested for bacterial endotoxins?
Yes. Every production lot of PT-141 undergoes chromogenic Limulus Amebocyte Lysate (LAL) testing to ensure endotoxin levels are well below standard limits for research reagents, preventing confounders in cell culture assays.
What solvents are recommended for reconstituting PT-141 in a lab setting?
For analytical and in vitro research, PT-141 can be reconstituted using sterile Bacteriostatic Water or endotoxin-free 0.9% Sodium Chloride / PBS. High-concentration stock solutions dissolve readily in aqueous buffers.
What are the primary melanocortin receptor targets of PT-141?
PT-141 acts primarily as a high-affinity agonist at the central MC3R and MC4R receptors, while demonstrating secondary agonist activity at MC1R and MC5R.
How should lyophilized PT-141 be stored upon arrival at the facility?
Lyophilized vials should be stored at -20°C or -80°C in a dry environment protected from direct light exposure. Avoid ambient humidity prior to reconstitution.
Where does PX1 Research ship PT-141 from, and how fast is delivery?
PX1 Research ships all research compounds directly from facilities located in California and Arizona. Orders placed Monday through Friday before cut-off times ship same-day.
Are batch-specific Certificates of Analysis available for download?
Yes. Every shipment includes lot documentation, and complete third-party Certificates of Analysis (COAs) detailing HPLC and MS results can be accessed directly on the PX1 Research website.
All products are sold strictly for laboratory and research use only. Not for human or veterinary use, diagnosis, treatment or consumption. Statements have not been evaluated by the FDA.