BPC-157 is a synthetic 15-amino-acid peptide derived from a protective protein found in human gastric juice. It is one of the most extensively studied peptides in the preclinical literature and is supplied strictly for laboratory research use.

Why is BPC-157 notable in peptide research?

Two features drive its research prominence: an unusually large preclinical literature across tissue-repair and gastrointestinal endpoints, and documented stability in gastric juice that is rare among peptides.

What purity standard applies to BPC-157?

PX1 specifies ≥ 99% purity by HPLC with identity confirmed by LC-MS. Every batch includes a lot-specific Certificate of Analysis and endotoxin screening.

How should BPC-157 be stored?

Lyophilized vials store at -20 °C long term or 2–8 °C short term, protected from light. Reconstituted with bacteriostatic water, reference a refrigerated working stability of roughly 28–30 days at 2–8 °C.

Is BPC-157 approved for human use?

No. BPC-157 is an unapproved research compound. All PX1 material is strictly for laboratory research use only and not for human or veterinary administration.

Compound Monograph — PX-BPC

BPC-157

Pentadecapeptide — gastric-derived body protection compound

For laboratory research use only. Not for human or veterinary use.

Compound data

Compound class: Pentadecapeptide — synthetic gastric protein fragment
Structure: 15-amino-acid sequence (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val)
Molecular formula: C62H98N16O22
Molar mass: ≈ 1,419.5 g/mol
CAS number: 137525-51-0
Presentation: Lyophilized powder — 5mg and 10mg vials
Purity specification: ≥ 99% by HPLC, identity confirmed by LC-MS
Distinguishing property: Stable in human gastric juice in published stability work

Overview

BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide derived from a protective protein sequence first isolated from human gastric juice. Its 15-amino-acid sequence does not occur as an isolated fragment in nature; it is produced synthetically for research purposes.

BPC-157 is among the most cited peptides in the preclinical literature, with published animal-model research spanning gastrointestinal, musculoskeletal, vascular, and nervous-system endpoints. A frequently noted property in the literature is its unusual stability in gastric juice relative to most peptides.

Mechanism in the research literature

Angiogenesis and growth-factor pathways

Published preclinical work has examined BPC-157 in the context of angiogenic signaling and growth-factor expression, including interactions with VEGF-pathway and nitric-oxide-system endpoints in animal models.

Nitric oxide system interaction

Multiple published studies describe BPC-157's interaction with the nitric oxide system, including counteraction of both NO-blockade and NO-overload models — a bidirectional pattern discussed across the preclinical literature.

Cytoprotective context

The parent protein's gastric origin frames the cytoprotective research context: published animal studies have examined mucosal, tendon, ligament, and organ-protective endpoints following BPC-157 administration in model systems.

Published research summary

Hundreds of published preclinical studies have examined BPC-157 in animal models of tendon, ligament, muscle, and gastrointestinal endpoints.
Published stability characterization documents resistance to degradation in human gastric juice — unusual among peptides and central to its research interest.
Published work has examined BPC-157 in combination-context research alongside TB-500 (the 'Wolverine' research pairing).
Every PX-BPC batch is released against ≥ 99% HPLC purity with LC-MS identity confirmation and a lot-specific Certificate of Analysis.

Handling, reconstitution & storage

Storage (lyophilized): -20 °C long term; 2–8 °C short term; protect from light
Reconstitution: Bacteriostatic water down the vial wall; swirl gently, never shake
Example ratio: 5mg vial + 2.0 mL diluent = 2.5 mg/mL (10 units = 250 mcg)
Stability (reconstituted): Reference ≈ 28–30 days refrigerated at 2–8 °C with bacteriostatic water
Freeze/thaw: Avoid repeated cycling of reconstituted solutions

Frequently asked questions

Related resources

BPC-157 product page Wolverine Stack research hub (BPC-157 + TB-500)Peptide reconstitution calculator

Research use only. BPC-157 (PX-BPC) is supplied exclusively as a laboratory research compound. It is not a drug, food, or cosmetic, and it is not intended for human or veterinary administration, diagnostic use, or household use. Statements on this page summarize published scientific literature for reference purposes and do not constitute medical advice or health claims. All PX1 Research batches ship with lot-specific Certificates of Analysis confirming ≥ 99% purity by HPLC and identity by LC-MS.