Core Heavyweights

GHK-Cu (Copper Tripeptide-1)

GHK-Cu is a naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine) studied extensively for extracellular matrix remodelling, collagen synthesis and antioxidant signalling.

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Cosmetic formulation guide

For topical research solutions, GHK-Cu is typically prepared at 0.05%–2% w/v in sterile water or a buffered vehicle. The characteristic deep blue colour indicates intact copper coordination; a green or brown shift suggests degradation or pH drift.

  • Target pH 4.5–7.0 for copper complex stability
  • Avoid strong reducing agents, ascorbic acid and high-heat processing
  • 1% solution = 100mg GHK-Cu per 10mL vehicle

Collagen synthesis literature

Published studies describe GHK-Cu stimulating collagen I and III synthesis, glycosaminoglycan production and metalloproteinase/TIMP balance in dermal fibroblast models.

Topical vs injectable handling

Lyophilized GHK-Cu powder can be prepared as either a topical research solution or a reconstituted vial for laboratory work. Handling, sterility and solvent choice differ; both are documented on the certificate of analysis.

Reconstitution calculator

Convert vial strength and bacteriostatic water volume into exact insulin-syringe unit marks.

Peptide reconstitution calculator

Vial strength (mg)
Bacteriostatic water (mL)
Target dose

Concentration

5 mg/mL

Draw volume

0.05 mL

Insulin syringe

5 units (IU)

U-100 insulin syringe (100 units = 1 mL)

5 IU
020406080100

10 mg + 2 mL = 5 mg/mL. A 250 mcg dose = 5 units on a U-100 syringe (40 doses per vial).

For laboratory and research use only. Not for human or veterinary use.

Need solvent? Buy bacteriostatic water (10mL / 30mL)

Frequently asked questions

What concentration should a GHK-Cu topical research solution be?

Most published cosmetic-science work uses 0.05% to 2% w/v. A 100mg vial dissolved in 10mL of vehicle produces a 1% solution.

Why is GHK-Cu blue?

The blue colour comes from the copper(II) ion coordinated to the tripeptide. Loss of that colour indicates the complex has degraded.

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