Mitochondrial & Longevity

MOTS-c (Research Grade)

MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded in the mitochondrial 12S rRNA gene. It translocates to the nucleus under metabolic stress and is a primary subject in AMPK and insulin-sensitivity research.

US cGMP Facility 99%+ HPLC Purity Public COAs Same-Day Dispatch

Shop MOTS-c

MOTS-c specifications

Reference data researchers look up before ordering mots-c. Every lot ships with documentation matching the batch number printed on the vial.

  • Class: mitochondrial-derived peptide (MDP)
  • Length: 16 amino acids
  • Pathway of interest: AMPK activation
  • Storage: -20°C lyophilized

MOTS-c purity testing and certificate of analysis

Each mots-c lot is released only after an independent purity panel. HPLC quantifies purity, LC-MS confirms molecular identity, and the lot-matched certificate is published so the number on your vial matches the report you download.

  • ≥99% HPLC purity specification
  • LC-MS mass confirmation on every batch
  • Endotoxin and sterility panel documentation
  • Lot-matched mots-c COA published on the certifications page

MOTS-c reconstitution and BAC water ratios

MOTS-c ships lyophilized. Reconstitute with bacteriostatic water containing 0.9% benzyl alcohol. The ratios below assume a standard U-100 insulin syringe.

  • 10mg vial + 2mL BAC water = 5mg per mL (10 units = 500mcg)
  • 10mg vial + 4mL BAC water = 2.5mg per mL (20 units = 500mcg)
  • Fully dissolves clear — cloudiness indicates a handling fault
  • Keep refrigerated once reconstituted

Where to buy mots-c

PX1 Research synthesizes and fills mots-c in a US cGMP-compliant facility rather than reselling imported material, so purity documentation traces back to the production lot. Multi-vial pricing steps down at 3, 5 and 10 vials, and subscription intervals are available on the product page.

Reconstitution calculator

Convert vial strength and bacteriostatic water volume into exact insulin-syringe unit marks.

Peptide reconstitution calculator

Vial strength (mg)
Bacteriostatic water (mL)
Target dose

Concentration

5 mg/mL

Draw volume

0.05 mL

Insulin syringe

5 units (IU)

U-100 insulin syringe (100 units = 1 mL)

5 IU
020406080100

10 mg + 2 mL = 5 mg/mL. A 250 mcg dose = 5 units on a U-100 syringe (40 doses per vial).

For laboratory and research use only. Not for human or veterinary use.

Need solvent? Buy bacteriostatic water (10mL / 30mL)

Frequently asked questions

What does MOTS-c do?

In published research it acts through AMPK signaling and folate-methionine metabolism, which is why it is studied in metabolic flexibility models.

Is MOTS-c encoded in mitochondrial DNA?

Yes — it is transcribed from the mitochondrial 12S rRNA open reading frame, not the nuclear genome.

Is a certificate of analysis provided with mots-c?

Yes. Every mots-c lot has a published, lot-matched COA showing HPLC purity and LC-MS identity confirmation.

How should mots-c be stored?

Store the lyophilized vial at -20°C protected from light. Once reconstituted with bacteriostatic water, keep it refrigerated at 2–8°C.

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