Made in the USA
Ships from the USA
Capsules
Strength
Quantity
Checking today's dispatch cutoff…
Cutoff is 2:30 PM Pacific on weekdays, 12:00 PM Pacific on Saturday.
Referral program · researchers save 15%, you earn 18% back
For research use only. Not for human or animal consumption.
Molecular weight
286.11 g/mol
Molecular formula
C10H11IN2
CAS number
42464-96-0
Chain length
Not assigned for this material
Classification: Non-peptide research compound
Iodide reference; counterion is included. Confirm the supplied salt against lot documentation.
Batch verification
Independent testing with lot-specific analytical documentation.
Lot Pending
Independent laboratory
Independent laboratory
HPLC purity
Pending
Result pending
Full GHS 16-section Safety Data Sheet for 5-Amino-1MQ (iodide reference), prepared per OSHA HazCom 2012 (29 CFR 1910.1200). Includes substance identity, handling & storage, PPE, stability, transport and regulatory information.
CAS No.
42464-96-0
Formula
C₁₀H₁₁IN₂
Mol. Weight
286.11 g/mol
Classification
Not hazardous (GHS)
Considered a highly selective and powerful inhibitor of NNMT (Nicotinamide N-Methyltransferase), 5-Amino-1MQ (5-Amino-1-methylquinolinium) has become a focal point in studies regarding anti-aging, weight loss mechanisms, and metabolic health. By blocking the NNMT enzyme, this compound prevents the transformation of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA). This intervention results in elevated intracellular NAD+, superior metabolic performance, and bolstered mitochondrial activity.
At PX1 Research, we supply 5-Amino-1MQ with a purity rating of ≥98%, confirmed through rigorous mass spectrometry and HPLC analysis to maintain total stability for experimental settings. This substance is developed exclusively for animal model and in vitro testing within regulated environments and is strictly not for veterinary or human applications.
In the study of adipose tissue control and energy regulation, 5 Amino 1MQ has shown significant promise via the following mechanisms:
Evidence-Based Publications:
5 Amino 1MQ is frequently utilized in cellular aging and rejuvenation trials due to its ability to:
Evidence-Based Publications: 3. Pissios et al. (2020) – *”5-Amino-1MQ extends healthspan by restoring NAD+ in aging models.”* PubMed Link 4. Ryu et al. (2022) – “NNMT inhibition enhances mitochondrial function and reduces age-related metabolic decline.” PubMed Link
Newer data indicates that 5 Amino 1MQ might:
Evidence-Based Publications: 5. Zhang et al. (2021) – *”5-Amino-1MQ enhances neuronal NAD+ and protects against cognitive decline.”* PubMed Link 6. Chen et al. (2023) – “NNMT inhibition reduces amyloid-beta accumulation in Alzheimer’s models.” PubMed Link
Note: These details are for reference only. Not intended for veterinary or human use.
| Study Model | Proposed Dosing Spectrum | Delivery Method |
|---|---|---|
| In vitro (Cellular) | 1–10 µM | Growth media |
| Murine (Mice) | 5–20 mg/kg | IP injection or Oral |
| Metabolic (Chronic) | 10–30 mg/kg | Laboratory gavage |
Purity verified at ≥98% via HPLC Lyophilized format to ensure maximum shelf life Independent laboratory verification available Rapid, confidential shipping across the USA Authorized for research use only (non-clinical)
5 Amino 1MQ represents a top-tier experimental agent with diverse uses in obesity, neuroscience, metabolic pathology, and gerontology studies. PX1 Research delivers high-standard chemical reagents developed specifically for scientific and academic inquiry only.
Notice: This material is distributed strictly for lab-based research usage. It is not for medical therapy, human intake, or veterinary procedures. By completing a purchase, you agree to follow all safety and legal guidelines.
5-Amino-1MQ functions as a targeted, potent inhibitor of NNMT that elevates NAD+ bioavailability, stimulates fat reduction, and aids metabolic homeostasis in research environments. Best suited for the study of:
Thermogenesis and white-to-brown fat conversion Longevity pathways and NAD+ replenishment Energy production and mitochondrial health Neurological protection and cognitive maintenance
Purity (HPLC)
≥99%
Application
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Testing
Third Party Tested
Manufacture
USA
99%+ HPLC Purity
Independently verified by accredited US laboratory
Endotoxin-Screened
LAL tested, LPS-free, endotoxin report available
GMP-Certified Manufacturing
USA facility, ISO 9001:2015
Lyophilized for Stability
Shipped cold-packed and sealed for stability
Studied for raising NAD+ levels, improving mitochondrial output and supporting fat-metabolism research.
For research use only — not for human or animal consumption.
Research monograph
5-Amino-1-methylquinolinium (5-Amino-1MQ) is a cell-permeable small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), not a peptide. It is supplied as a lyophilized powder for in-vitro metabolic research.
NNMT is highly expressed in adipose tissue and liver, and its inhibition is a well-documented approach for probing the NAD+ salvage pathway in cell culture.
NNMT consumes S-adenosylmethionine to methylate nicotinamide, diverting nicotinamide away from NAD+ resynthesis. Inhibiting NNMT with 5-Amino-1MQ raises intracellular nicotinamide and, in adipocyte models, has been reported to increase NAD+ and sirtuin-1 activity.
Because the readouts overlap with NAD+ precursor work, 5-Amino-1MQ is frequently studied in parallel with NAD+ itself to distinguish salvage-pathway effects from direct cofactor supplementation.
5-Amino-1MQ ships as a lyophilized powder in a sealed, tamper-evident vial. Store the unopened vial between −20°C and −80°C, protected from light, until the day of use. In this state the peptide is stable through the labeled expiration date printed on the lot documentation.
Every PX1 Research lot of 5-Amino-1MQ is manufactured in the United States and released against a documented specification of ≥99% purity by reversed-phase HPLC, with identity confirmed on the same lot by high-resolution LC-MS against the theoretical mass of the sequence.
5-Amino-1MQ supplied by PX1 Research is intended strictly for in-vitro laboratory and research applications. It is not a drug, food, cosmetic, or medical device, and it is not for human or veterinary use, diagnosis, treatment, or consumption.
Researchers are responsible for handling the compound in accordance with their institution's safety procedures and all applicable local regulations. Safety data sheets and current lot documentation are available on this site.
All products are sold strictly for laboratory and research use only. Not for human or veterinary use, diagnosis, treatment or consumption. Statements have not been evaluated by the FDA.
High Quality — 99% Purity Guaranteed
We are continuously conducting HPLC testing on all of our raw powders as well as our finished products to ensure the quality of what we ship. You can have the product you bought from us independently tested at any HPLC-licensed testing facility — and if the results come back negative, we will refund the following:
HPLC Test Fee
$100
Plus a full refund
Total order amount + shipping
5-Amino-1MQ Capsules
$189.00