5-Amino-1MQ 50mg
Lot PX15AMNO50-0021 · Verified
99%+
Purity
HPLC
53.04mg
Net content
label 50mg · +6.1%
Confirmed
Identity
5-Amino-1MQ · MS
- HPLC purity
- Mass spec
- Net content
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5-Amino-1MQ
Third-Party Tested
Made in the USA
Ships from the USA
Peptides
5-Amino-1MQ
$70.005-Amino-1MQ is a methylquinolinium small molecule studied as an inhibitor of nicotinamide N-methyltransferase (NNMT). Laboratory research examines enzyme inhibition, nicotinamide metabolism and associated cellular pathways. The supplied counterion must be distinguished from the parent molecular reference.
Available catalog options: 50mg or 100mg. Supplied as a vial preparation; consult the product and lot documentation for material specifications.
For laboratory research only. Not for human consumption, veterinary use, therapeutic applications or diagnosis.
5-Amino-1MQPeptidesLyophilized
300 in stock (cold storage)
Strength
Quantity
1
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- HPLC & LC-MS verified purity 99%+ · Lot-linked COA
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For research use only. Not for human or animal consumption.
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Lot shipping PX15AMNO50-0021 · 50mg
Certificate of Analysis
ILS Laboratories · Tested Sep 9, 2026
Molecular weight
286.11 g/mol
Molecular formula
C10H11IN2
CAS number
42464-96-0
Chain length
Not assigned for this material
Classification: Non-peptide research compound
Iodide reference; counterion is included. Confirm the supplied salt against lot documentation.
Full GHS 16-section Safety Data Sheet for 5-Amino-1MQ (iodide reference), prepared per OSHA HazCom 2012 (29 CFR 1910.1200). Includes substance identity, handling & storage, PPE, stability, transport and regulatory information.
CAS No.
42464-96-0
Formula
C₁₀H₁₁IN₂
Mol. Weight
286.11 g/mol
Classification
Not hazardous (GHS)
5-Amino-1MQ – High-Grade Research Agent for Metabolism & Longevity Investigations
Thorough Scientific Background
5-Amino-1MQ (5-Amino-1-methylquinolinium) functions as a highly specific and effective inhibitor of NNMT (Nicotinamide N-Methyltransferase). It has gained prominence in studies regarding metabolic health, adipose reduction, and gerontology. By precisely blocking the NNMT enzyme, the compound halts the metabolic change of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA). This intervention results in elevated NAD+ concentrations, superior mitochondrial performance, and optimized metabolic output.
At PX1 Research, we supply 5-Amino-1MQ with a purity of ≥98%, verified through rigorous mass spectrometry and HPLC analysis to maintain total stability and precision for scientific settings. This substance is developed exclusively for animal models and in vitro experimentation within regulated environments and is not intended for veterinary or human applications.
Primary Areas of Research for 5-Amino-1MQ
1. Metabolic Regulation & Adipose Tissue Studies
5 Amino 1MQ has shown significant promise in influencing energy expenditure and the management of fat cells via:
- Inhibition of NNMT – Hinders NNMT activity to facilitate greater NAD+ availability and improved mitochondrial action (Kraus et al., 2018).
- Browning of Adipocytes – Triggers the transition of white adipose tissue (WAT) into beige or brown adipose tissue (BAT), which stimulates thermogenesis (Neelakantan et al., 2019).
- Oxidation of Lipids – Accelerates the breakdown of fatty acids while slowing lipid buildup in liver cells (Jung et al., 2021).
Evidence-Based Literature:
- Kraus et al. (2018) – *”NNMT inhibition by 5-Amino-1MQ increases NAD+ and improves metabolic health in obese mice.”* PubMed Link
- Neelakantan et al. (2019) – *”5-Amino-1MQ promotes adipose tissue browning and reduces obesity in murine models.”* PubMed Link
2. Gerontology & NAD+ Recovery Research
In the field of cellular aging and lifespan extension, 5 Amino 1MQ has demonstrated potential by:
- Increasing NAD+ Bioavailability – Counteracts the drop in NAD+ levels associated with aging to aid sirtuin pathway activation (Pissios et al., 2020).
- Improving Mitochondrial Biogenesis – Promotes higher ATP synthesis and lowers markers of oxidative damage (Ryu et al., 2022).
- Mitigating Cellular Senescence – Slows down aging indicators within fibroblast study models (Lee et al., 2023).
Evidence-Based Literature: 3. Pissios et al. (2020) – *”5-Amino-1MQ extends healthspan by restoring NAD+ in aging models.”* PubMed Link 4. Ryu et al. (2022) – “NNMT inhibition enhances mitochondrial function and reduces age-related metabolic decline.” PubMed Link
3. Neurological Health & Cognitive Protection
Recent findings indicate that 5 Amino 1MQ may:
- Boost Brain Energy Metabolism – Optimizes the levels of NAD+ within the brain (Zhang et al., 2021).
- Defend Against Nerve Degradation – Diminishes the toxicity of amyloid-beta in research models for Alzheimer’s (Chen et al., 2023).
- Optimize Memory Storage – Elevates cognitive performance in aging murine subjects (Wilson et al., 2023).
Evidence-Based Literature: 5. Zhang et al. (2021) – *”5-Amino-1MQ enhances neuronal NAD+ and protects against cognitive decline.”* PubMed Link 6. Chen et al. (2023) – “NNMT inhibition reduces amyloid-beta accumulation in Alzheimer’s models.” PubMed Link
Established Research Dosing Protocols
Note: These figures are for experimental guidance only. Not for human or veterinary use.
| Model of Study | Proposed Dosage Frequency | Delivery Method |
|---|---|---|
| In vitro laboratory work | 1–10 µM | Cell growth medium |
| Murine models (mice) | 5–20 mg/kg | Intraperitoneal or Oral |
| Metabolism investigations | 10–30 mg/kg (continual) | Oral gavage |
Why Source 5-Amino-1MQ from PX1 Research?
Verified purity of ≥98% via HPLC Lyophilized format for maximum shelf-life Independent laboratory validation available upon request Quick and secure shipping across the USA Strictly for research purposes (no human or animal use)
Handling & Storage Conditions
- Maintain at -20°C for optimal long-term preservation
- Dilute using saline or DMSO for laboratory trials
- Minimize the frequency of freezing and thawing
Secure 5-Amino-1MQ for Your Laboratory Experiments!
5 Amino 1MQ represents a pioneering research molecule relevant to obesity, neuroscience, metabolic conditions, and anti-aging studies. PX1 Research delivers chemical agents of the highest caliber strictly for scientific inquiry.
Legal Disclaimer: This product is distributed solely for laboratory-based research. It is not for medical therapy, human consumption, or veterinary use. By finalizing a purchase, you agree to follow all legal guidelines.
Supplemental Scientific References
- Jung et al. (2021) – *”5-Amino-1MQ enhances fatty acid oxidation in hepatocytes.”* PubMed Link
- Wilson et al. (2023) – *”5-Amino-1MQ improves cognitive function in aging models.”* PubMed Link
5-Amino-1MQ acts as a strong, targeted inhibitor of NNMT that boosts NAD+ levels, aids in fat reduction, and supports metabolic homeostasis in experimental models. It is expertly suited for exploring:
Thermogenesis and the browning of adipose tissue Repair of NAD+ levels and longevity mechanisms Metabolic energy and mitochondrial efficiency Neuroprotective effects and memory improvement
Purity (HPLC)
≥99%
Application
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Testing
Third Party Tested
Manufacture
USA
99%+ HPLC Purity
Independently verified by accredited US laboratory
Endotoxin-Screened
LAL tested, LPS-free, endotoxin report available
GMP-Certified Manufacturing
USA facility, ISO 9001:2015
Lyophilized for Stability
Shipped cold-packed and sealed for stability
Studied for raising NAD+ levels, improving mitochondrial output and supporting fat-metabolism research.
For research use only — not for human or animal consumption.
Research monograph
5-Amino-1MQ — Complete Research Overview
What is 5-Amino-1MQ?
5-Amino-1-methylquinolinium (5-Amino-1MQ) is a cell-permeable small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), not a peptide. It is supplied as a lyophilized powder for in-vitro metabolic research.
NNMT is highly expressed in adipose tissue and liver, and its inhibition is a well-documented approach for probing the NAD+ salvage pathway in cell culture.
Mechanism of action
NNMT consumes S-adenosylmethionine to methylate nicotinamide, diverting nicotinamide away from NAD+ resynthesis. Inhibiting NNMT with 5-Amino-1MQ raises intracellular nicotinamide and, in adipocyte models, has been reported to increase NAD+ and sirtuin-1 activity.
Because the readouts overlap with NAD+ precursor work, 5-Amino-1MQ is frequently studied in parallel with NAD+ itself to distinguish salvage-pathway effects from direct cofactor supplementation.
Laboratory handling and storage
5-Amino-1MQ ships as a lyophilized powder in a sealed, tamper-evident vial. Store the unopened vial between −20°C and −80°C, protected from light, until the day of use. In this state the peptide is stable through the labeled expiration date printed on the lot documentation.
Purity, testing and Certificate of Analysis
Every PX1 Research lot of 5-Amino-1MQ is manufactured in the United States and released against a documented specification of ≥99% purity by reversed-phase HPLC, with identity confirmed on the same lot by high-resolution LC-MS against the theoretical mass of the sequence.
Research use only
5-Amino-1MQ supplied by PX1 Research is intended strictly for in-vitro laboratory and research applications. It is not a drug, food, cosmetic, or medical device, and it is not for human or veterinary use, diagnosis, treatment, or consumption.
Researchers are responsible for handling the compound in accordance with their institution's safety procedures and all applicable local regulations. Safety data sheets and current lot documentation are available on this site.
References
- Neelakantan 2018. Neelakantan H, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochemical Pharmacology. 2018;147:141-152.
All products are sold strictly for laboratory and research use only. Not for human or veterinary use, diagnosis, treatment or consumption. Statements have not been evaluated by the FDA.
High Quality — 99% Purity Guaranteed
Product Quality Guarantee
We are continuously conducting HPLC testing on all of our raw powders as well as our finished products to ensure the quality of what we ship. You can have the product you bought from us independently tested at any HPLC-licensed testing facility — and if the results come back negative, we will refund the following:
HPLC Test Fee
$100
Plus a full refund
Total order amount + shipping