alphaKlothoLR

alphaKlothoLR — Research Overview

alphaKlothoLR is a long-release recombinant α-Klotho protein construct for in vitro research. It combines the 1012-amino-acid α-Klotho protein with a 29-amino-acid albumin-binding peptide (GGSGGSGGSGGRLIEDICLPRWGCLWEDD) via a glycine-serine linker, giving strong albumin binding affinity (<20 nM Kd) while maintaining native FGF23 binding activity (15–30 nM). The full construct runs ~133–135 kDa and shows sustained cellular activity of up to 19 days in laboratory models. Produced through recombinant expression and verified by HPLC and LC-MS for molecular identity and purity. Research applications include protein-albumin interactions, FGF23 signaling pathways, and albumin-binding mechanisms. Manufactured in America with complete analytical documentation. Each order includes two 10mcg vials. For laboratory research use only.

Supplied as a research-grade compound for in-vitro and laboratory investigation.

Research classification and format

alphaKlothoLR is classified on this page as a research peptide and is supplied in a lyophilized research preparation. The presentation is intended to support controlled laboratory workflows, analytical method development, and documented preclinical or in-vitro investigation appropriate to the compound.

PX1 quality and documentation

PX1 Research manufactures and finishes this product in American GMP laboratories rather than purchasing finished vials from overseas. Each released lot is evaluated through the PX1 quality program, with identity, purity, appearance, and applicable contaminant or endotoxin results documented on the lot-linked Certificate of Analysis. Researchers should review the current COA and Safety Data Sheet shown on this page before beginning work.

Laboratory handling

Store the sealed preparation at −20°C for long-term stability and protect it from light. Bring the closed vial to room temperature before opening, follow the laboratory's validated preparation protocol, and minimize repeated freeze–thaw cycles. Use calibrated equipment, document concentration and storage conditions, and follow institutional safety procedures throughout the study.

Intended use

For research use only. Not for human or veterinary use, consumption, diagnosis, treatment, or medical application. This material should be handled only by qualified professionals in an appropriate laboratory setting.