Is PX1's PNC-27 made in the USA?

Yes. PNC-27 is manufactured in GMP-certified facilities in the United States — never imported as a finished vial. Every lot is manufactured, purity-tested and packaged domestically.

How do I verify the purity and COA for PNC-27?

Each batch ships with a lot-specific Certificate of Analysis showing 99%+ HPLC purity, mass-spec identity confirmation and endotoxin results. The current batch's report is published on this page and matches the exact vial you receive.

How is PNC-27 shipped and stored?

Lyophilized vials are shipped domestically and are stable at room temperature for transit. For long-term storage keep vials cold; once reconstituted, refrigerate at 2–8°C and use within about 30 days.

Is PNC-27 for human use?

No. All PX1 Research compounds are sold strictly for in-vitro laboratory and research use only — not for human or animal consumption, and not for diagnostic or therapeutic use.

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Third-Party Tested PNC-27

Made in the USA

Ships from the USA

Lot PNC27-10-5915

Peptides

PNC-27

Name: PNC-27
Brand: PX1 Research
SKU: pnc-27
Availability: InStock

$250.00

PNC-27 combines a p53-derived MDM2-binding segment with a membrane-penetrating sequence. In vitro research examines membrane-associated MDM2 interactions, pore formation and cellular membrane responses in defined cell models.

Available catalog options: 10mg. Supplied as a vial preparation; consult the product and lot documentation for material specifications.

For laboratory research only. Not for human consumption, veterinary use, therapeutic applications or diagnosis.

PNC-27PeptidesLyophilized

837 in stock (cold storage)

Strength

Quantity

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Same-day dispatch before 2:30 PM Pacific · Free UPS 2-Day over $250
837 in stock in cold storage
HPLC & LC-MS verified purity 99%+ · Lot-linked COA

We accept:AMEXDISC●VERACH$ZV

For research use only. Not for human or animal consumption.

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In testing · 10mg

Certificate of Analysis

Independent laboratory · Results pending

PNC-27 10mg

Lot Pending · In testing

Pending

Purity

HPLC

Pending

Net content

label 10mg

Pending

Identity

Pending · MS

Peak graph available when testing is complete

PNC-27 – Membrane-Active Anticancer Research Peptide

PNC-27 is a membrane-active peptide for in vitro anticancer research applications that selectively kills cancer cells by binding to HDM-2 on their membranes and inducing necrosis through pore formation.

Product Description

PNC-27 is a synthetic peptide designed to selectively kill cancer cells by targeting a protein called HDM-2 (also known as MDM2) found on the membranes of many cancer cells. It works by binding to membrane-bound HDM-2, forming pores in the cancer cell membrane, and causing rapid cell death through necrosis, while sparing normal cells.

PNC-27 is derived from the p53 protein's HDM-2 binding domain (amino acids 12-26) and is linked to a membrane-penetrating sequence, allowing it to enter and act on cancer cell membranes. The peptide binds specifically to HDM-2 present on the surface of cancer cells, not normal cells. This binding leads to the formation of transmembrane pores, disrupting the cell membrane and causing cell lysis and necrosis, independent of the p53 pathway.

Peptide Information

Property	Value
Peptide Sequence	Pro-Pro-Leu-Ser-Gln-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly
Molecular Formula	C188H293N53O44S
Molecular Weight	4029.2 g/mol
CAS Number	1159861-00-3
Synonyms	H-PPLSQETFSDLWKLLKKWKMRRNQFWVKVQRG-OH, A6, Paralit

Product Usage

THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug.

This product is for laboratory research purposes only. Not for human or animal consumption.

High Quality — 99% Purity Guaranteed

Product Quality Guarantee

We are continuously conducting HPLC testing on all of our raw powders as well as our finished products to ensure the quality of what we ship. You can have the product you bought from us independently tested at any HPLC-licensed testing facility — and if the results come back negative, we will refund the following:

HPLC Test Fee

$100

Plus a full refund

Total order amount + shipping