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Peptides
PNC-27 – Membrane-Active Anticancer Research Peptide
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For research use only. Not for human or animal consumption.
Molecular weight
Not assigned for this material
Molecular formula
Not assigned for this material
CAS number
Not assigned for this material
Chain length
Not assigned for this material
Classification: Research peptide
The complete primary structure is reported only when it can be verified for the exact compound and modification supplied.
Batch verification
Independent testing with lot-specific analytical documentation.
Lot Pending
Independent laboratory
Independent laboratory
HPLC purity
Pending
Result pending
Full GHS 16-section Safety Data Sheet for PNC-27, prepared per OSHA HazCom 2012 (29 CFR 1910.1200). Includes substance identity, handling & storage, PPE, stability, transport and regulatory information.
CAS No.
Not assigned
Formula
Not assigned
Mol. Weight
Per COA
Classification
Not hazardous (GHS)
PNC-27 is a membrane-active peptide for in vitro anticancer research applications that selectively kills cancer cells by binding to HDM-2 on their membranes and inducing necrosis through pore formation.
PNC-27 is a synthetic peptide designed to selectively kill cancer cells by targeting a protein called HDM-2 (also known as MDM2) found on the membranes of many cancer cells. It works by binding to membrane-bound HDM-2, forming pores in the cancer cell membrane, and causing rapid cell death through necrosis, while sparing normal cells.
PNC-27 is derived from the p53 protein's HDM-2 binding domain (amino acids 12-26) and is linked to a membrane-penetrating sequence, allowing it to enter and act on cancer cell membranes. The peptide binds specifically to HDM-2 present on the surface of cancer cells, not normal cells. This binding leads to the formation of transmembrane pores, disrupting the cell membrane and causing cell lysis and necrosis, independent of the p53 pathway.
| Property | Value |
|---|---|
| Peptide Sequence | Pro-Pro-Leu-Ser-Gln-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly |
| Molecular Formula | C188H293N53O44S |
| Molecular Weight | 4029.2 g/mol |
| CAS Number | 1159861-00-3 |
| Synonyms | H-PPLSQETFSDLWKLLKKWKMRRNQFWVKVQRG-OH, A6, Paralit |
THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug.
This product is for laboratory research purposes only. Not for human or animal consumption.
Purity (HPLC)
≥99%
Application
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Testing
Third Party Tested
Manufacture
USA
99%+ HPLC Purity
Independently verified by accredited US laboratory
Endotoxin-Screened
LAL tested, LPS-free, endotoxin report available
GMP-Certified Manufacturing
USA facility, ISO 9001:2015
Lyophilized for Stability
Shipped cold-packed and sealed for stability
Investigated for selectively binding membrane-bound HDM-2 on cancer cells and inducing necrosis through transmembrane pore formation, independent of the p53 pathway.
For research use only — not for human or animal consumption.
High Quality — 99% Purity Guaranteed
We are continuously conducting HPLC testing on all of our raw powders as well as our finished products to ensure the quality of what we ship. You can have the product you bought from us independently tested at any HPLC-licensed testing facility — and if the results come back negative, we will refund the following:
HPLC Test Fee
$100
Plus a full refund
Total order amount + shipping
PNC-27 10mg
$250.00