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Research monograph on PT-141 (bremelanotide) — a cyclic heptapeptide melanocortin receptor agonist derived from melanotan II.
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For research use only. Not for human or animal consumption.
Molecular weight
1025.16 g/mol
Molecular formula
C₅₀H₆₈N₁₄O₁₀
CAS number
189691-06-3
Chain length
Not assigned for this material
Classification: Research peptide
The complete primary structure is reported only when it can be verified for the exact compound and modification supplied.
Batch verification
Independent testing with lot-specific analytical documentation.
Lot Pending
Independent laboratory
Independent laboratory
HPLC purity
Pending
Result pending
Full GHS 16-section Safety Data Sheet for PT-141, prepared per OSHA HazCom 2012 (29 CFR 1910.1200). Includes substance identity, handling & storage, PPE, stability, transport and regulatory information.
CAS No.
189691-06-3
Formula
C₅₀H₆₈N₁₄O₁₀
Mol. Weight
1025.16 g/mol
Classification
Not hazardous (GHS)
PT-141 (Bremelanotide) is a synthetic heptapeptide derivative of Melanotan II that exhibits specific binding preferences for melanocortin receptors, focusing primarily on MC3R and MC4R. This innovative peptide serves as a critical laboratory instrument for the exploration of central nervous system activities, neuroendocrine signaling, and the regulation of behavior. Distinguishing itself from peptides that function through peripheral pathways, PT-141 possesses the ability to cross the blood-brain barrier directly, making it exceptionally useful for investigating central melanocortin circuits and their broad physiological impacts.
At PX1 Research, we supply pharmaceutical-grade PT-141 (purity ≥98%) in a freeze-dried state, validated through HPLC and mass spectrometry to guarantee superior stability and experimental consistency. This substance is developed strictly for in vitro and animal-based scientific research within regulated laboratory environments and is not intended for human or veterinary applications.
The biological activity of PT-141 is mediated through complex interactions with melanocortin receptors:
• Specific Receptor Targeting: Exhibits a strong affinity for the MC4R (Melanocortin 4 Receptor) and notable interaction with MC3R, while displaying negligible binding to MC1R, MC2R, or MC5R (Hadley, 2005)
• CNS Access: Penetrates the blood-brain barrier effectively thanks to its lipophilic nature and low molecular weight, allowing for direct modulation of the central nervous system (King et al., 2007)
• Dopamine System Interaction: Triggers an indirect release of dopamine within the nucleus accumbens via melanocortin receptor stimulation, influencing reward-seeking behavior and motivation (Martin et al., 2011)
• Nitric Oxide Pathways: Promotes nitric oxide synthase activity across targeted neural networks, which aids in its physiological outcomes (Rosen et al., 2013)
Studies in neurology have highlighted the significant impact of PT-141:
Neuroendocrine Response Study:
Blood-Brain Barrier Penetration Study:
Investigations show the utility of PT-141 in studying behavioral patterns:
Motivation and Reward Pathways:
Social Behavior Modulation:
Current data indicates substantial influence over autonomic functions:
Cardiovascular Regulation:
Thermoregulatory Effects:
Reminder: The following protocols are strictly for experimental design and are not for human or animal consumption.
| Research Model | Dosage Range | Administration | Frequency | Key Parameters |
|---|---|---|---|---|
| In Vitro Studies | 1-100 μM | Cell culture media | 24-48 hour exposure | Signal transduction, binding kinetics |
| Rodent Models | 0.1-2.0 mg/kg | Subcutaneous injection | Acute or chronic | Neural mapping, behavior |
| Primate Models | 0.05-0.5 mg/kg | Subcutaneous/IV | Acute study sessions | Physiological data, CNS entry |
| Receptor Studies | 0.1-10 nM | Binding assays | 60-120 min incubation | Affinity and activation levels |
For precise laboratory use:
PX1 Research upholds strict quality benchmarks to ensure data reproducibility:
• Purity Standards: Minimum 98% purity verified via HPLC • Sequence Integrity: Mass spectrometry utilized for amino acid confirmation • Endotoxin Levels: Tested at <0.1 EU/mg • Sterility Assurance: Certified through membrane filtration processes • Documentation: Each batch includes a detailed Certificate of Analysis (CoA)
Versus Other Melanocortin Agonists:
Versus Behavioral Research Compounds:
Available Formats:
Technical Support:
Shipping & Handling:
Intended Use: This product is provided strictly for laboratory-based research and is not intended for human or veterinary use. It is meant for in vitro and animal studies conducted by trained professionals in specialized facilities.
Regulatory Compliance: The buyer acknowledges and agrees to follow all local, state, and federal regulations regarding the acquisition, storage, and application of research chemicals. This includes adherence to the Animal Welfare Act and internal IACUC guidelines.
Safety Handling: Laboratory personnel must wear proper personal protective equipment (PPE), such as eye protection, lab coats, and gloves. Standard laboratory safety protocols are mandatory.
Quality Assurance: While PX1 Research guarantees high-tier quality through strict validation, researchers are responsible for confirming the product's suitability for their specific experimental needs.
Liability: PX1 Research denies any liability for damages caused by the unauthorized use, improper storage, or misuse of this substance. Purchasing this product constitutes acceptance of these terms.
Research Ethics: Use of this product must be governed by ethically sanctioned research protocols, ensuring the humane treatment of animals and sound experimental logic.
References:
Purity (HPLC)
≥99%
Application
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Testing
Third Party Tested
Manufacture
USA
99%+ HPLC Purity
Independently verified by accredited US laboratory
Endotoxin-Screened
LAL tested, LPS-free, endotoxin report available
GMP-Certified Manufacturing
USA facility, ISO 9001:2015
Lyophilized for Stability
Shipped cold-packed and sealed for stability
Investigated for melanocortin-receptor signaling linked to sexual-health pathways.
For research use only — not for human or animal consumption.
Research monograph
PT-141, also known as bremelanotide, is a cyclic seven-amino-acid melanocortin receptor agonist and the deaminated metabolite of melanotan II. Removing the C-terminal amide shifts the pharmacology away from pigmentation-associated MC1R signaling toward MC3R and MC4R activity.
PX1 Research supplies lyophilized PT-141 as a reference compound for central melanocortin receptor research and receptor-selectivity profiling.
PT-141 acts as a non-selective agonist across melanocortin receptor subtypes with functional preference for MC4R, a receptor densely expressed in hypothalamic nuclei. Receptor activation is Gs-coupled and raises intracellular cAMP.
In laboratory work PT-141 is commonly profiled against alpha-MSH and melanotan II in cAMP reporter assays to map subtype selectivity across MC1R through MC5R.
PT-141 ships as a lyophilized powder in a sealed, tamper-evident vial. Store the unopened vial between −20°C and −80°C, protected from light, until the day of use. In this state the peptide is stable through the labeled expiration date printed on the lot documentation.
Every PX1 Research lot of PT-141 is manufactured in the United States and released against a documented specification of ≥99% purity by reversed-phase HPLC, with identity confirmed on the same lot by high-resolution LC-MS against the theoretical mass of the sequence.
PT-141 supplied by PX1 Research is intended strictly for in-vitro laboratory and research applications. It is not a drug, food, cosmetic, or medical device, and it is not for human or veterinary use, diagnosis, treatment, or consumption.
Researchers are responsible for handling the compound in accordance with their institution's safety procedures and all applicable local regulations. Safety data sheets and current lot documentation are available on this site.
All products are sold strictly for laboratory and research use only. Not for human or veterinary use, diagnosis, treatment or consumption. Statements have not been evaluated by the FDA.
High Quality — 99% Purity Guaranteed
We are continuously conducting HPLC testing on all of our raw powders as well as our finished products to ensure the quality of what we ship. You can have the product you bought from us independently tested at any HPLC-licensed testing facility — and if the results come back negative, we will refund the following:
HPLC Test Fee
$100
Plus a full refund
Total order amount + shipping
PT-141 10mg
$87.99