PT-141 10mg

PT-141 (Bremelanotide) – Premium Research Peptide for Central Nervous System & Melanocortin Receptor Studies

PT-141 Comprehensive Scientific Overview

PT-141 (Bremelanotide) is a synthetic heptapeptide derivative of Melanotan II that exhibits specific binding preferences for melanocortin receptors, focusing primarily on MC3R and MC4R. This innovative peptide serves as a critical laboratory instrument for the exploration of central nervous system activities, neuroendocrine signaling, and the regulation of behavior. Distinguishing itself from peptides that function through peripheral pathways, PT-141 possesses the ability to cross the blood-brain barrier directly, making it exceptionally useful for investigating central melanocortin circuits and their broad physiological impacts.

At PX1 Research, we supply pharmaceutical-grade PT-141 (purity ≥98%) in a freeze-dried state, validated through HPLC and mass spectrometry to guarantee superior stability and experimental consistency. This substance is developed strictly for in vitro and animal-based scientific research within regulated laboratory environments and is not intended for human or veterinary applications.

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PT-141 Mechanism of Action: Advanced Neurological Pathways

The biological activity of PT-141 is mediated through complex interactions with melanocortin receptors:

• Specific Receptor Targeting: Exhibits a strong affinity for the MC4R (Melanocortin 4 Receptor) and notable interaction with MC3R, while displaying negligible binding to MC1R, MC2R, or MC5R (Hadley, 2005)

• CNS Access: Penetrates the blood-brain barrier effectively thanks to its lipophilic nature and low molecular weight, allowing for direct modulation of the central nervous system (King et al., 2007)

• Dopamine System Interaction: Triggers an indirect release of dopamine within the nucleus accumbens via melanocortin receptor stimulation, influencing reward-seeking behavior and motivation (Martin et al., 2011)

• Nitric Oxide Pathways: Promotes nitric oxide synthase activity across targeted neural networks, which aids in its physiological outcomes (Rosen et al., 2013)

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PT-141 Key Research Applications & Evidence-Based Studies

1. Central Nervous System Research

Studies in neurology have highlighted the significant impact of PT-141:

Neuroendocrine Response Study:

• Methodology: 0.1-1.0 mg/kg via subcutaneous delivery in rodent subjects
• Findings: Observed dose-proportional stimulation of hypothalamic neurons and heightened c-Fos expression in brain centers regulating autonomic tasks (Vergoni et al., 2009)
• Path: Direct stimulation of MC4R within CNS nuclei

Blood-Brain Barrier Penetration Study:

• Methodology: 0.5 mg/kg administered intravenously in primate subjects
• Findings: Rapid entry into the CNS within a 10-15 minute window, with receptor attachment lasting between 2 to 4 hours (King et al., 2007)

2. Behavioral Neuroscience Research

Investigations show the utility of PT-141 in studying behavioral patterns:

Motivation and Reward Pathways:

• Methodology: 0.25-2.0 mg/kg via subcutaneous injection in rodent subjects
• Findings: Boosted motivational drives, increased frequency of operant responses for rewards, and shifts in reward value perception (Martin et al., 2011)

Social Behavior Modulation:

• Methodology: 0.1-0.5 mg/kg doses utilized during social interaction assessments
• Findings: Changes in social engagement tendencies and adjustments in social hierarchy dynamics (Minakova et al., 2012)

3. Autonomic Nervous System Effects

Current data indicates substantial influence over autonomic functions:

Cardiovascular Regulation:

• Methodology: 0.5-2.0 mg/kg via intravenous injection in canine subjects
• Findings: Dose-linked elevations in heart rate and blood pressure resulting from central sympathetic activation (Van der Ploeg et al., 2002)

Thermoregulatory Effects:

• Methodology: 0.1-1.0 mg/kg subcutaneous delivery in thermal regulation trials
• Findings: Altered internal temperature responses mediated by hypothalamic MC4R pathways (Adan et al., 2006)

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PT-141 Research Application Guidelines

Recommended Research Dosages

Reminder: The following protocols are strictly for experimental design and are not for human or animal consumption.

Reconstitution & Handling

• Diluent: Saline solution or sterile bacteriostatic water
• Storage: Powder form remains stable for 24 months at -20°C
• Reconstituted: Remains stable for 30 days when kept at 4°C
• Light Sensitivity: Ensure the product is shielded from light during use and storage

Experimental Preparation

For precise laboratory use:

1. Reconstitute using the required amount of bacteriostatic water
2. Swirl the vial gently until the powder is fully dissolved (avoid shaking/vortexing)
3. Dilute the solution to the desired concentration using sterile saline
4. Use immediately or store at 4°C while protecting from light exposure

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Quality Assurance & Verification

PX1 Research upholds strict quality benchmarks to ensure data reproducibility:

• Purity Standards: Minimum 98% purity verified via HPLC • Sequence Integrity: Mass spectrometry utilized for amino acid confirmation • Endotoxin Levels: Tested at <0.1 EU/mg • Sterility Assurance: Certified through membrane filtration processes • Documentation: Each batch includes a detailed Certificate of Analysis (CoA)

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Comparative Research Advantages

Versus Other Melanocortin Agonists:

• Refined Receptor Profile: Focuses activity on MC3R/MC4R rather than a wider receptor range
• Superior CNS Access: Crosses the blood-brain barrier more effectively than larger peptide chains
• Biochemical Durability: Increased resistance to breakdown by enzymes
• Targeted Research: Offers more specific results compared to non-selective agonists

Versus Behavioral Research Compounds:

• Unique Pathway: Operates through a distinct melanocortin-driven mechanism
• Consistent Responses: Reliable dose-response relationships throughout various models
• Holistic Behavioral Impact: Touches upon multiple facets of motivated action
• Extensively Documented: Supported by a large body of peer-reviewed data

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Research Limitations & Considerations

1. Dose Sensitivity: Concentrations can result in biphasic response patterns
2. Model Variability: Effects may differ depending on the species being studied
3. Chronobiology: The time of administration may impact the resulting data
4. State Dependency: Existing behavioral conditions may interact with the peptide’s effects

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Ordering Information & Research Support

Available Formats:

• 10mg vial (lyophilized powder) – $59.99
• 25mg vial (lyophilized powder) – $129.99
• Bulk options (100mg to 1g) available upon request
• Manufacturing services for unique research requirements

Technical Support:

• Consultation with PhD-level scientists
• Assistance in designing experimental protocols
• Customizing bulk orders

Shipping & Handling:

• Packaging designed for temperature stability
• Discrete domestic shipping (USA)
• Priority handling for university and institutional orders

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Complete Research Disclaimer

Intended Use: This product is provided strictly for laboratory-based research and is not intended for human or veterinary use. It is meant for in vitro and animal studies conducted by trained professionals in specialized facilities.

Regulatory Compliance: The buyer acknowledges and agrees to follow all local, state, and federal regulations regarding the acquisition, storage, and application of research chemicals. This includes adherence to the Animal Welfare Act and internal IACUC guidelines.

Safety Handling: Laboratory personnel must wear proper personal protective equipment (PPE), such as eye protection, lab coats, and gloves. Standard laboratory safety protocols are mandatory.

Quality Assurance: While PX1 Research guarantees high-tier quality through strict validation, researchers are responsible for confirming the product's suitability for their specific experimental needs.

Liability: PX1 Research denies any liability for damages caused by the unauthorized use, improper storage, or misuse of this substance. Purchasing this product constitutes acceptance of these terms.

Storage & Stability: Keep the lyophilized powder at -20°C in its original, light-protected container. It is shelf-stable for 24 months from production. Reconstituted liquid should be used within 30 days and kept at 4°C.

Research Ethics: Use of this product must be governed by ethically sanctioned research protocols, ensuring the humane treatment of animals and sound experimental logic.

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References:

1. Reduction in corpora lutea number in obese melanocortin-4-receptor-deficient mice. PubMed
2. Evaluation of PT-141 safety and pharmacokinetics in healthy males and patients with inadequate response to Viagra. PubMed
3. PT-141 induces penile erection via brain and spinal melanocortin receptors. PubMed
4. Melanotan II enhances proceptive sexual behaviors in female rats. PubMed
5. Bremelanotide as a salvage treatment for sildenafil failures. PubMed
6. Anti-fungal and anti-inflammatory effects of melanocortin against Candida albicans. PubMed
7. Skin cancer risks associated with MC1-R variants. PubMed
8. Skin phototype and melanocortin receptor activity. PubMed
9. Melanotan II and thermogenic capacity in mice. PubMed
10. Bremelanotide’s effect on body weight in obese women. PubMed