Selank 10mg

Selank 5mg (Freeze-Dried Peptide) – strictly for Laboratory Research

Product details:

• Catalog #: SEL-5MG
• Form: Lyophilized (dry-frozen) powder
• Purity: No less than 99% (verified via HPLC)
• Quantity: 5mg total per unit
• Storage: Pre-reconstitution: -20°C / Post-reconstitution: 2-8°C
• Shipping: Transported at ambient temperatures with cooling packs (product is heat-sensitive)

Key research applications:

• Investigation of anxiolytic effects absent of sedative property
• Research into memory preservation and cognitive enhancement
• Regulation studies of neurotransmitters (norepinephrine, dopamine, and serotonin)
• Experiments involving cytokine and neuroinflammatory control
• Studies of immunotropic pathways

Handling:

• Rehydrate utilizing bacteriostatic sterile water. Roll or swirl the vial softly – avoid vortexing. Divide into aliquots to prevent repeated cycles of freezing and thawing.

Important:

• This substance is provided solely for animal studies and in vitro experimentation. Not for human use, therapeutic application, or diagnosis. Handling is restricted to trained professionals wearing required PPE.

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Overview

Selank is a lab-manufactured heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, modeled after the naturally occurring immunomodulatory fragment tuftsin. Initially manufactured at the Russian Academy of Sciences' Institute of Molecular Genetics, Selank has undergone substantial clinical and preclinical testing to determine its impact on neuroinflammation, cognitive performance, neurotransmitter levels, and anxious behaviors.

Prepared in a 5mg lyophilized format, this product is intended for in vivo and in vitro laboratory use, such as receptor studies, cell culture assays, analytical validation, and animal modeling. PX1 Research does not supply this product for veterinary or human consumption outside of a controlled research environment.

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Chemical & Physical Properties

• Molecular Formula: C₃₃H₅₇N₁₁O₉
• Molecular Weight: 751.87 g/mol
• Sequence: H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH (may be acetate salt depending on the lot)
• Appearance: Powder or lyophilized cake in white to off-white
• Solubility: Dissolves in 0.9% NaCl (saline), sterile water, or pH 5–6 PBS. Do not shake the solution aggressively.
• Stability: Maintains integrity when stored per instructions. Minimize repeated freeze-thaw events once reconstituted.

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Primary Research Applications

Scientists have utilized Selank in systematic laboratory environments to explore the following biological pathways:

1. Non-Sedative Anxiolytic Activity

In contrast to traditional benzodiazepines, Selank research models do not show evidence of amnesia, impaired motor coordination, or muscular relaxation. Experiments using open field tests and elevated plus-mazes have demonstrated dose-responsive decreases in anxiety markers, hinting at a unique modulation of the GABAergic framework via a non-classical route.

2. Nootropic Potential and Cognitive Support

In rodent trials involving stress-related cognitive decline or scopolamine-induced amnesia, research suggests improvements in memory retention and new learning. This may be linked to Selank’s ability to affect brain-derived neurotrophic factor (BDNF) levels and promote neurogenesis in the hippocampus during stressful periods.

3. Regulation of Neuroinflammation

Due to its similarity to tuftsin, Selank displays immunotropic characteristics. Research indicates the peptide may lower pro-inflammatory markers like TNF-α, IL-6, and IL-1β while boosting the anti-inflammatory cytokine IL-10 within CNS tissues. This makes it a subject of interest for pain research, brain injury, and chronic stress models.

4. Neurotransmitter Homeostasis

Tissue analysis and microdialysis studies indicate that Selank can modify extracellular concentrations of dopamine (DA), serotonin (5-HT), and norepinephrine (NE) within the hippocampus and prefrontal cortex. These shifts are specific to brain regions and dosage, providing a foundation for mechanistic research.

5. Antiviral and Immune Studies (In Vitro)

Because of its structural homology to tuftsin, Selank has been studied for its capacity to influence interferon-gamma (IFN-γ) and various antiviral pathways in immune cell cultures. These exploratory applications are extensively detailed in peer-reviewed immunological journals.

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Quality Assurance & Testing

PX1 Research subjects every lot of Selank 5mg to strict quality benchmarks:

• HPLC Purity: Minimum 99% (chromatograms provided upon request)
• Mass Spectrometry (MS): Target molecular weight confirmed within ±0.05%
• Residual Solvent Analysis: Compliant with ICH Q3C standards
• Endotoxin Testing: Below 1.0 EU/mg (via LAL test)
• Sterility: Processed through 0.22µm filters prior to freeze-drying

A specialized Certificate of Analysis (CoA) accompanies every purchase.

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Reconstitution & Handling Protocol (For Laboratory Use Only)

1. Equilibrate the vial to room temperature before seal removal to prevent moisture buildup.
2. Introduce 1–2 mL of sterile 0.9% saline or bacteriostatic water into the powder.
3. Swirl the vial gently – avoid shaking or vortexing to prevent peptide denaturation.
4. Wait for full dissolution (usually 1–3 minutes), ensuring the liquid is clear and lacks visible particles.
5. Divide into aliquots to avoid multiple freeze-thaw cycles. Store at 2–8°C for 30 days maximum, or at -20°C for extended use.

Standard Research Dosages (Animal Subjects): Generally 0.1 – 1.0 mg/kg administered via subcutaneous (SC) or intraperitoneal (IP) injection. The specific protocol and dosage must be established by the lead investigator.

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Safety & Legal Disclaimer

FOR RESEARCH PURPOSES ONLY. NOT FOR HUMAN OR VETERINARY USE.

• This substance is not a food, medicine, dietary supplement, or drug.
• Strictly not for recreational, diagnostic, or therapeutic purposes.
• Unapproved for human use by the MHRA, FDA, EMA, or other health authorities.
• To be used exclusively by qualified scientists in professional lab settings.
• Never administer to human beings or pets.
• Proper personal protective equipment (PPE), including eye protection, lab coats, and gloves, is mandatory during handling.

By completing this purchase, you verify you are 18 years or older and that Selank 5mg will be used only for legal research efforts.

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References (Selected Peer-Reviewed Literature)

1. Volkova, A. V., et al. (2016). Neuroscience and Behavioral Physiology, 46(3), 273–278.
2. Kolik, L. G., et al. (2014). Bulletin of Experimental Biology and Medicine, 157(3), 351–354.
3. Zozulya, A. A., et al. (2008). Bulletin of Experimental Biology and Medicine, 145(3), 340–343.
4. Uchakina, O. N., et al. (2014). Pharmaceutical Chemistry Journal, 48(1), 10–13.

Extended bibliographies are available on request.

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