What is Selank?
Selank is a synthetic heptapeptide consisting of the immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg) extended with the tripeptide Pro-Gly-Pro, which markedly increases stability against enzymatic degradation.
PX1 Research supplies lyophilized Selank as a reference compound for neuropeptide research, where it is studied alongside Semax as part of the regulatory-peptide class developed from endogenous fragments.
Mechanism of action
In rodent models Selank has been reported to modulate GABAergic and serotonergic signaling and to influence expression of brain-derived neurotrophic factor. It has also been described as altering the balance of enkephalin-degrading enzyme activity, which prolongs endogenous enkephalin signaling.
Its tuftsin heritage also gives it documented effects on immune-cell readouts in culture, so experiments frequently pair neurological and immunological endpoints.
Laboratory handling and storage
Selank ships as a lyophilized powder in a sealed, tamper-evident vial. Store the unopened vial between −20°C and −80°C, protected from light, until the day of use. In this state the peptide is stable through the labeled expiration date printed on the lot documentation.
Allow the vial to reach room temperature before opening so atmospheric moisture does not condense onto the lyophilized cake. Introduce bacteriostatic or sterile water slowly against the vial wall, then swirl — never shake — until the solution is clear. Store the reconstituted solution at 2–8°C, aliquot to avoid repeated freeze–thaw cycles, and record the lot number in your laboratory notebook alongside the reconstitution date.
Purity, testing and Certificate of Analysis
Every PX1 Research lot of Selank is manufactured in the United States and released against a documented specification of ≥99% purity by reversed-phase HPLC, with identity confirmed on the same lot by high-resolution LC-MS against the theoretical mass of the sequence.
Release testing covers six layers: HPLC purity, LC-MS identity, endotoxin by kinetic chromogenic LAL, residual solvents by gas chromatography, water content by Karl Fischer titration, and visual inspection of appearance and reconstitution. The batch-specific Certificate of Analysis is published on this page, and the lot number on the vial label matches the report so the material in your hand traces back to the data you can read online.
Research use only
Selank supplied by PX1 Research is intended strictly for in-vitro laboratory and research applications. It is not a drug, food, cosmetic, or medical device, and it is not for human or veterinary use, diagnosis, treatment, or consumption.
Researchers are responsible for handling the compound in accordance with their institution's safety procedures and all applicable local regulations. Safety data sheets and current lot documentation are available on this site.
References
- Kolomin 2013. Kolomin T, et al. Transcriptomic response of rat hippocampus and spleen cells to single and chronic administration of the peptide Selank. Doklady Biological Sciences. 2013;449:113-116.
All products are sold strictly for laboratory and research use only. Not for human or veterinary use, diagnosis, treatment or consumption. Statements have not been evaluated by the FDA.