Semax 5mg
Lot Pending · In testing
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Purity
HPLC
Pending
Net content
label 5mg
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Identity
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Peak graph available when testing is complete
Semax
Third-Party Tested
Made in the USA
Ships from the USA
Lot SEMAX-05-5218
Peptides
Semax
$65.00Semax is a synthetic ACTH-fragment-related heptapeptide. Laboratory and preclinical studies examine neurotrophic signaling, BDNF-associated pathways and cellular responses to experimental neurological stress.
Available catalog options: 5mg or 10mg or 30mg. Supplied as a vial preparation; consult the product and lot documentation for material specifications.
For laboratory research only. Not for human consumption, veterinary use, therapeutic applications or diagnosis.
SemaxPeptidesLyophilized
1,434 in stock (cold storage)
Strength
Quantity
1
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- 1,434 in stock in cold storage
- HPLC & LC-MS verified purity 99%+ · Lot-linked COA
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For research use only. Not for human or animal consumption.
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In testing · 5mg
Certificate of Analysis
Independent laboratory · Results pending
Molecular weight
813.92 g/mol
Molecular formula
C₃₇H₅₁N₉O₁₀S
CAS number
80714-61-0
Chain length
7 amino acids
Amino-acid sequence
Met-Glu-His-Phe-Pro-Gly-Pro
Classification: Research peptide
Full GHS 16-section Safety Data Sheet for Semax, prepared per OSHA HazCom 2012 (29 CFR 1910.1200). Includes substance identity, handling & storage, PPE, stability, transport and regulatory information.
CAS No.
80714-61-0
Formula
C₃₇H₅₁N₉O₁₀S
Mol. Weight
813.92 g/mol
Classification
Not hazardous (GHS)
Semax — ACTH(4-10)-Derived Heptapeptide
Semax is a synthetic 7-amino-acid peptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. It joins the ACTH(4-7) fragment to a Pro-Gly-Pro tail, which slows enzymatic breakdown compared with the unmodified fragment. It was developed in Russia and is studied mainly in rodent neuroscience models.
Research context
- In rat hippocampus, Semax changed the expression of BDNF and its receptor TrkB (Dolotov et al., Brain Research, 2006).
- It is used as a reference peptide in studies of melanocortin-derived fragments and neurotrophin signaling.
These findings describe specific model systems. They do not establish any outcome for the material supplied here.
Semax specifications
- CAS Number: 80714-61-0
- Molecular Formula: C37H51N9O10S
- Molecular Weight: ≈813.9 g/mol
- Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (7 residues)
- Form: Lyophilized white powder in a sealed glass vial
- Strengths: shown in the strength options on this page
- Storage: Sealed at −20 °C, dry and protected from light
Analytical considerations
Identity is confirmed by LC-MS against the theoretical mass and purity is measured by reversed-phase HPLC. Methionine can oxidize, so storage away from air and light matters. The lot-linked COA on this page reports the results for the material you receive.
Laboratory handling
Bring the closed vial to room temperature before opening, prepare solutions according to your laboratory's validated protocol, and record the lot number, concentration and storage conditions. Minimize repeated freeze–thaw cycles.
Common research questions
What is the difference between Semax and Selank? They are unrelated sequences. Semax comes from ACTH(4-10); Selank comes from tuftsin. PX1 lists each on its own page and also offers a Selank + Semax blend.
Does PX1 offer Semax in other formats? Yes. A nasal format is listed separately with its own page and documentation.
References
- Dolotov OV, et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res. 2006. PMID 16996037.
Intended use
For research use only. Not for human or veterinary use, consumption, diagnosis, treatment or medical application. This material should be handled only by qualified professionals in an appropriate laboratory setting.
Purity (HPLC)
≥99%
Application
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Testing
Third Party Tested
Manufacture
USA
99%+ HPLC Purity
Independently verified by accredited US laboratory
Endotoxin-Screened
LAL tested, LPS-free, endotoxin report available
GMP-Certified Manufacturing
USA facility, ISO 9001:2015
Lyophilized for Stability
Shipped cold-packed and sealed for stability
Investigated in preclinical models for neurotrophic signaling, BDNF-pathway expression and cellular responses to neurological stress.
For research use only — not for human or animal consumption.
Research monograph
Semax — Complete Research Overview
What is Semax?
Semax is a synthetic heptapeptide analog of the ACTH(4-10) fragment, extended at the C-terminus with Pro-Gly-Pro to resist peptidase cleavage. Unlike the parent hormone fragment, Semax lacks corticotropic activity, which allows researchers to isolate the neurotropic component of melanocortin signaling.
PX1 Research supplies lyophilized Semax as a reference neuropeptide for cognitive, neuroprotection and BDNF-pathway research.
Mechanism of action
Semax has been reported in rodent models to elevate brain-derived neurotrophic factor and its receptor TrkB in the hippocampus, and to modulate dopaminergic and serotonergic turnover. Transcriptomic studies describe broad changes in genes related to the immune response and vascular tone following administration in ischemia models.
In laboratory comparisons Semax and Selank are studied together as the two best-characterized members of the Russian regulatory-peptide class.
Laboratory handling and storage
Semax ships as a lyophilized powder in a sealed, tamper-evident vial. Store the unopened vial between −20°C and −80°C, protected from light, until the day of use. In this state the peptide is stable through the labeled expiration date printed on the lot documentation.
Purity, testing and Certificate of Analysis
Every PX1 Research lot of Semax is manufactured in the United States and released against a documented specification of ≥99% purity by reversed-phase HPLC, with identity confirmed on the same lot by high-resolution LC-MS against the theoretical mass of the sequence.
Research use only
Semax supplied by PX1 Research is intended strictly for in-vitro laboratory and research applications. It is not a drug, food, cosmetic, or medical device, and it is not for human or veterinary use, diagnosis, treatment, or consumption.
Researchers are responsible for handling the compound in accordance with their institution's safety procedures and all applicable local regulations. Safety data sheets and current lot documentation are available on this site.
References
- Dolotov 2006. Dolotov OV, et al. Semax, an analogue of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Research. 2006;1117(1):54-60.
All products are sold strictly for laboratory and research use only. Not for human or veterinary use, diagnosis, treatment or consumption. Statements have not been evaluated by the FDA.
High Quality — 99% Purity Guaranteed
Product Quality Guarantee
We are continuously conducting HPLC testing on all of our raw powders as well as our finished products to ensure the quality of what we ship. You can have the product you bought from us independently tested at any HPLC-licensed testing facility — and if the results come back negative, we will refund the following:
HPLC Test Fee
$100
Plus a full refund
Total order amount + shipping