SNAP-8 (Acetyl Octapeptide-3) — Research Overview

SNAP-8 is a synthetic, eight-residue peptide also catalogued as acetyl octapeptide-3 or acetyl glutamyl heptapeptide-3. Its sequence, Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, corresponds to the N-terminal region of SNAP-25, one of the three proteins that form the SNARE complex. It is an elongated analog of the hexapeptide acetyl hexapeptide-3, extended by alanine and aspartate, and carries an N-terminal acetyl group and a C-terminal amide.

Research context

SNAP-8 is used as a laboratory tool in SNARE-complex research. Experimental work examines how short SNAP-25-derived sequences interact with SNARE proteins, and how such interactions relate to vesicle docking, membrane fusion and neurotransmitter-release models in vitro. It is also used as a reference compound when comparing truncated SNARE-interacting peptides with the shorter hexapeptide and with full-length proteins. Findings in model systems describe the peptide's behavior in those systems only; they do not establish a cosmetic, clinical or therapeutic outcome.

Analytical considerations

N-terminal acetylation and C-terminal amidation are part of SNAP-8's identity; a non-acetylated or free-acid sequence is a different material. Methionine in the sequence is susceptible to oxidation, so identity confirmation by LC-MS against the theoretical mass and purity assessment by reversed-phase HPLC are the standard checks. The lot-linked Certificate of Analysis on this page reports the results for the supplied material.

PX1 Research SNAP-8 specifications

• Name: SNAP-8 (Acetyl Octapeptide-3)
• CAS Number: 868844-74-0
• Molecular Formula: C41H70N16O16S
• Molecular Weight: 1075.17 g/mol
• Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (8 residues)
• Class: Synthetic linear octapeptide (SNAP-25 N-terminal fragment analog)
• Quantity: 10mg per vial
• Form: Lyophilized white to off-white powder in a sealed glass vial
• Storage: Store sealed at −20°C, dry and protected from light; minimize repeated freeze–thaw cycles after preparation.

Laboratory handling

Bring the closed vial to room temperature before opening, prepare solutions according to the laboratory's validated protocol, and record the lot number, concentration and storage conditions. Use calibrated equipment and follow institutional safety procedures throughout the study.

Intended use

For research use only. Not for human or veterinary use, consumption, diagnosis, treatment, cosmetic or medical application. This material should be handled only by qualified professionals in an appropriate laboratory setting.