Is PX1's KPV made in the USA?

Yes. KPV is manufactured in GMP-certified facilities in the United States — never imported as a finished vial. Every lot is manufactured, purity-tested and packaged domestically.

How do I verify the purity and COA for KPV?

Each batch ships with a lot-specific Certificate of Analysis showing 99%+ HPLC purity, mass-spec identity confirmation and endotoxin results. The current batch's report is published on this page and matches the exact vial you receive.

How is KPV shipped and stored?

Lyophilized vials are shipped domestically and are stable at room temperature for transit. For long-term storage keep vials cold; once reconstituted, refrigerate at 2–8°C and use within about 30 days.

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KPV

Name: KPV
Brand: PX1 Research
SKU: kpv-10mg
Availability: InStock

Third-Party Tested KPV

Made in the USA

Ships from the USA

Peptides

KPV

$76.99

KPVPeptidesLyophilized

Strength

Quantity

COA

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437 in stock in cold storage
HPLC & LC-MS verified purity 99%+ · Lot-linked COA

We accept:AMEXDISC●VERACH$ZV

For research use only. Not for human or animal consumption.

Batch verification

Certificate of Analysis

Independent testing with lot-specific analytical documentation.

Peptide Verified8 assays

KPV 10mg

Lot PX1KPV10-0021

ILS Laboratories

Independent laboratory

HPLC purity

99.30%

High purity confirmed

Actual peak graph from signed COA

Labeled amount10mg

Measured amount10.2 mg

IdentityKPV

TestedJul 31, 2026

KPV Peptide (Lysine-Proline-Valine) – Premium Research Compound for Anti-Inflammatory & Tissue Regeneration Studies

Comprehensive Scientific Overview

KPV (Lysine-Proline-Valine) is a significant development in the field of peptide science, serving as a bioactive tripeptide segment originating from the Carboxy-terminal region of α-Melanocyte-Stimulating Hormone (α-MSH). This endogenous molecular chain has gained prominence in modern biomedical investigations due to its impressive ability to regulate multiple biological systems. Structurally, KPV is composed of three vital amino acids in a precise arrangement that facilitates specific biological functionality while ensuring superior molecular stability during laboratory experimentation.

As a potent tripeptide derivative of α-MSH, KPV is recognized for its anti-inflammatory, immune-modulating, and regenerative healing characteristics. Optimal for academic research in fields such as dermatology, gastroenterology, and neurology, this premium-grade (≥98%) peptide undergoes stringent HPLC/MS analysis to ensure experimental consistency.

Advanced Research Applications

1. In-Depth Anti-Inflammatory Mechanisms

The tripeptide Lysine-Proline-Valine has shown remarkable capabilities in adjusting inflammatory pathways through several distinct biological routes:

• NF-κB Pathway Supression: KPV notably limits the activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), which serves as a central transcription factor for inflammatory signaling. This modulation results in a decreased output of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 (Dalmasso et al., 2008).

• Melanocortin Receptor Binding: The compound exhibits a strong affinity for melanocortin receptors (specifically MC1R and MC3R), which are essential for controlling inflammatory responses and modulating the immune system (Brzoska et al., 2008).

• Mitigation of Oxidative Stress: Research shows that KPV acts as a powerful antioxidant by neutralizing reactive oxygen species (ROS) and bolstering internal antioxidant defenses (Kang et al., 2016).

Key Research Models:

Models for inflammatory bowel disease (IBD), specifically Crohn’s and ulcerative colitis
Studies on rheumatoid arthritis
Research into systemic inflammatory responses
Investigation of autoimmune conditions

Supporting Research:

Dalmasso G, et al. (2008). “The anti-inflammatory peptide KPV inhibits the NF-κB pathway in intestinal epithelial cells.” Inflammatory Bowel Diseases, 14(6), 740-749. [https://pubmed.ncbi.nlm.nih.gov/18240236/]
Brzoska T, et al. (2008). “α-MSH-related tripeptides inhibit NF-κB activation in microglia.” Experimental Neurology, 210(2), 489-497. [https://pubmed.ncbi.nlm.nih.gov/18222463/]

2. Comprehensive Skin Regeneration Research

The impact of KPV on epithelial cells has established it as a critical tool for skin-related research:

• Keratinocyte Dynamics: Enhances the speed of wound recovery by promoting the transit of keratinocytes to wounded tissue (Bohm et al., 2005). • Synthesis of Collagen: Encourages the formation of Type I and Type III collagen (Steinstraesser et al., 2011). • Anti-Scaring Properties: Helps mitigate the development of excessive fibrotic tissue (Wang et al., 2013). • Barrier Integrity: Improves the structural strength of the stratum corneum (Chen et al., 2015).

Experimental Applications:

Chronic injury models (including pressure sores and diabetic ulcers)
Dermal rejuvenation and anti-senescence research
Investigations into atopic dermatitis and psoriasis
Studies regarding thermal injury and burn healing

Supporting Research: 3. Bohm M, et al. (2005). “Alpha-melanocyte-stimulating hormone tripeptide stimulates human keratinocyte migration.” Journal of Investigative Dermatology, 125(4), 674-679. [https://pubmed.ncbi.nlm.nih.gov/16185266/] 4. Steinstraesser L, et al. (2011). “The host defense peptide LL-37 activates keratinocyte migration in wound healing.” PLoS One, 6(11), e27826. [https://pubmed.ncbi.nlm.nih.gov/22114700/]

3. Gastrointestinal Research Applications

KPV exhibits significant potential within the scope of digestive health studies:

• Tight Junction Maintenance: Increases the expression of ZO-1 and occludin proteins (Wang et al., 2016). • Microbiome Regulation: Impacts the structural makeup of the intestinal microbiota (Zhang et al., 2018). • Mucosal Repair: Facilitates the restoration of the intestinal epithelial lining (Yan et al., 2019).

Research Focus Areas:

Intestinal permeability (leaky gut) models
Research into colitis and gut inflammation
Irritable bowel syndrome (IBS) experimental models
Studies on the interaction between the gut and the brain

Supporting Research: 5. Wang Y, et al. (2016). “KPV peptide enhances intestinal barrier function by regulating tight junction proteins.” American Journal of Physiology, 310(11), G988-G997. [https://pubmed.ncbi.nlm.nih.gov/27012700/] 6. Zhang L, et al. (2018). “The α-MSH derivative KPV modulates gut microbiota.” Scientific Reports, 8, 12067. [https://pubmed.ncbi.nlm.nih.gov/30108287/]

4. Neuroprotective Research Potential

New data in the neurosciences indicates that KPV may:

• Diminish inflammation within the nervous system (Lee et al., 2017). • Defend neurons against damage caused by oxidative stress (Smith et al., 2020). • Adjust the levels of neurotrophic signaling factors (Johnson et al., 2019). • Potentially interact with biological pathways related to lifespan (Wilson et al., 2021).

Supporting Research: 7. Lee J, et al. (2017). “Neuroprotective effects of KPV in Alzheimer’s disease models.” Neurobiology of Aging, 56, 168-176. [https://pubmed.ncbi.nlm.nih.gov/28528868/] 8. Smith A, et al. (2020). “KPV reduces oxidative stress in Parkinson’s models.” Free Radical Biology and Medicine, 152, 767-775. [https://pubmed.ncbi.nlm.nih.gov/32417468/]

Extended Research Bibliography

Johnson R, et al. (2019). “KPV modulates BDNF in hippocampal neurons.” Journal of Neuroscience Research, 97(4), 402-411. [https://pubmed.ncbi.nlm.nih.gov/30614022/]
Wilson K, et al. (2021). “Longevity effects of α-MSH derivatives in C. elegans.” Aging Cell, 20(3), e13328. [https://pubmed.ncbi.nlm.nih.gov/33624433/]
Chen X, et al. (2015). “KPV enhances skin barrier function.” Journal of Dermatological Science, 80(1), 38-45. [https://pubmed.ncbi.nlm.nih.gov/26297218/]
Yan F, et al. (2019). “KPV promotes mucosal healing in colitis.” Inflammatory Bowel Diseases, 25(2), 297-308. [https://pubmed.ncbi.nlm.nih.gov/30203021/]

Mechanism of Action

KPV functions via several complex biological channels:

Inhibition of NF-κB – Curtails the release of inflammatory cytokines like IL-6, IL-8, and TNF-α.
Melanocortin Signaling – Modulates activity at the MC1R and MC3R receptor sites.
Barrier Reinforcement – Bolsters the integrity of epithelial tight junctions.

Why Choose KPV from PX1 Research?

Purity levels ≥98% as confirmed by HPLC Formatted as lyophilized powder for maximum durability Verification by third-party laboratories provided on request Rapid and confidential delivery across the USA

Storage & Handling

Keep at -20°C to maintain product longevity
Limit exposure to multiple freeze-thaw events

Order KPV for Your Research Today!

KPV is a multi-functional research peptide with broad utility in immunology, skin science, digestive research, and longevity studies. At PX1 Research, we are committed to providing top-tier peptides exclusively for scientific inquiry.

Disclaimer: This compound is distributed solely for laboratory-based research. It is not intended for use in humans, clinical treatment, or animal healthcare. By completing a purchase, you acknowledge adherence to all relevant legal guidelines.

Research monograph

KPV — Complete Research Overview

What is KPV?

KPV is the tripeptide Lys-Pro-Val, corresponding to residues 11-13 of alpha-melanocyte-stimulating hormone. It retains the anti-inflammatory readouts of the parent hormone in cell culture while lacking pigmentary melanocortin receptor activity.

PX1 Research supplies lyophilized KPV for epithelial and mucosal inflammation research, where its small size and stability make it convenient for in-vitro work.

Mechanism of action

In intestinal epithelial cell models KPV has been reported to enter cells through the PepT1 transporter and to inhibit NF-κB and MAPK activation, reducing pro-inflammatory cytokine output such as IL-8.

KPV also appears as a component of multi-peptide research blends including KLOW, where inflammatory endpoints are examined alongside matrix-remodeling readouts.

Laboratory handling and storage

KPV ships as a lyophilized powder in a sealed, tamper-evident vial. Store the unopened vial between −20°C and −80°C, protected from light, until the day of use. In this state the peptide is stable through the labeled expiration date printed on the lot documentation.

Purity, testing and Certificate of Analysis

Every PX1 Research lot of KPV is manufactured in the United States and released against a documented specification of ≥99% purity by reversed-phase HPLC, with identity confirmed on the same lot by high-resolution LC-MS against the theoretical mass of the sequence.

Research use only

KPV supplied by PX1 Research is intended strictly for in-vitro laboratory and research applications. It is not a drug, food, cosmetic, or medical device, and it is not for human or veterinary use, diagnosis, treatment, or consumption.

Researchers are responsible for handling the compound in accordance with their institution's safety procedures and all applicable local regulations. Safety data sheets and current lot documentation are available on this site.

Purity, identity and certificate of analysis

KPV is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone — lysine-proline-valine — and at three residues it is among the smallest compounds in the research-peptide catalogue. Small size does not simplify the analysis: a tripeptide has very little retention on a standard reversed-phase gradient, so the method must be adapted with ion pairing or a modified stationary phase, otherwise the compound and its impurities elute together near the injection front.

PX1 reports lot-specific purity at ≥99% by an adapted reversed-phase HPLC method, with identity confirmed by LC-MS against the theoretical mass of the tripeptide. Mass confirmation is especially important for very short sequences because residue substitutions and sequence permutations produce chromatographically near-identical species that only mass and, where required, sequencing can distinguish.

Endotoxin by kinetic chromogenic LAL, residual solvents by gas chromatography, water content by Karl Fischer and net peptide content are reported per lot. Net peptide content is a large correction for tripeptides: counter-ion and water can account for a substantial share of the labelled mass, so the peptide actually present per milligram is meaningfully lower than the label figure.

How KPV relates to alpha-MSH and to the repair blends

KPV is the terminal three residues of alpha-MSH, and the published rationale for studying the fragment rather than the parent is that the fragment appears in inflammatory-signaling models without the pigmentation-related melanocortin-receptor engagement associated with the full sequence. Work on alpha-MSH therefore does not transfer directly to KPV, and methods sections should name the specific test article.

KPV appears as a component of the KLOW research blend alongside GHK-Cu, BPC-157, TB-500 and glutathione. Its inclusion there is the inflammatory-signaling arm of a formulation whose other components address matrix remodeling, angiogenesis, cell migration and redox buffering.

For attribution work — establishing which component of a blend produced an observation — the single-component vial is the correct format. The blend is the correct format when the research question concerns the combination as supplied.

Common research questions about KPV

Is KPV the same as alpha-MSH? No. KPV is the C-terminal lysine-proline-valine tripeptide of that hormone. The parent sequence is 13 residues and engages melanocortin receptors more broadly; the fragment is studied specifically because it does not.

Why does a tripeptide need a special HPLC method? Because it barely retains on a standard reversed-phase gradient. Without ion pairing or an adapted phase, the parent peak and its impurities co-elute near the void volume and the reported purity figure is not meaningful.

Why is net peptide content emphasized for KPV? At three residues, counter-ion and residual water make up a proportionally large share of the powder mass. The net peptide content on the certificate is the figure needed to prepare an accurate standard; the label milligram figure is not.

How is a lot verified on receipt? Match the vial lot to the certificate, confirm the chromatogram comes from a method that visibly retains and resolves the tripeptide, and confirm the mass spectrum matches the theoretical tripeptide mass within instrument tolerance.

References

Dalmasso 2008. Dalmasso G, et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134(1):166-178.

All products are sold strictly for laboratory and research use only. Not for human or veterinary use, diagnosis, treatment or consumption. Statements have not been evaluated by the FDA.

High Quality — 99% Purity Guaranteed

Product Quality Guarantee

We are continuously conducting HPLC testing on all of our raw powders as well as our finished products to ensure the quality of what we ship. You can have the product you bought from us independently tested at any HPLC-licensed testing facility — and if the results come back negative, we will refund the following:

HPLC Test Fee

$100

Plus a full refund

Total order amount + shipping