PNC-27 10mg
Lot Pending · In testing
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Purity
HPLC
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Net content
label 10mg
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Identity
Pending · MS
Peak graph available when testing is complete
PNC-27
Third-Party Tested
Made in the USA
Ships from the USA
Lot PNC27-10-5915
Peptides
837 in stock (cold storage)
PNC-27
$250.00PNC-27 combines a p53-derived MDM2-binding segment with a membrane-penetrating sequence.
837 in stock (cold storage)
Strength
Pack size
10-vial kits: 3 kit minimum.Kits (10 vials) are sold on the Buy Kits page, 3 kit minimum. Shop Buy Kits
1
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837 in stock in cold storage
HPLC & LC-MS verified purity 99%+Lot-linked COA
- Same-day dispatch before 2:00 PM Pacific · Free UPS 2-Day over $250
- 837 in stock in cold storage
- HPLC & LC-MS verified purity 99%+ · Lot-linked COA
We accept:AMEXDISC●VERACH$ZV
For research use only. Not for human or animal consumption.
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In testing · 10mg
Certificate of Analysis
Independent laboratory · Results pending
About PNC-27
PNC-27 • Membrane-active anticancer peptide • 10mg • Third party tested • Research use only
Membrane-active anticancer peptide · Research peptide
PNC-27
PNC-27 combines a p53-derived MDM2-binding segment with a membrane-penetrating sequence.
Investigated for selectively binding membrane-bound HDM-2 on cancer cells and inducing necrosis through transmembrane pore formation, independent of the p53 pathway.
10mg
Strength
99%+
HPLC purity
Lyophilized
Form
-20°C
Long-term storage
99%+ HPLC Purity
Independently verified by accredited US laboratory
Endotoxin-Screened
LAL tested, LPS-free, endotoxin report available
GMP-Certified Manufacturing
USA facility, ISO 9001:2015
Lyophilized for Stability
Shipped cold-packed and sealed for stability
What's in the vial
Identity. Weight. Sequence.
Molecular weight
4031.73 g/mol
Molecular formula
C₁₈₈H₂₉₃N₅₃O₄₄S
CAS number
1159861-00-3
Chain length
Not assigned for this material
Classification: Research peptide
The complete primary structure is reported only when it can be verified for the exact compound and modification supplied.
Specifications & quality
Purity (HPLC)
99%+
Application
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Testing
Third Party Tested
Manufacture
USA
About this compound
PNC-27 – Membrane-Active Anticancer Research Peptide
PNC-27 is a membrane-active peptide for in vitro anticancer research applications that selectively kills cancer cells by binding to HDM-2 on their membranes and inducing necrosis through pore formation.
Product Description
PNC-27 is a synthetic peptide designed to selectively kill cancer cells by targeting a protein called HDM-2 (also known as MDM2) found on the membranes of many cancer cells. It works by binding to membrane-bound HDM-2, forming pores in the cancer cell membrane, and causing rapid cell death through necrosis, while sparing normal cells.
PNC-27 is derived from the p53 protein's HDM-2 binding domain (amino acids 12-26) and is linked to a membrane-penetrating sequence, allowing it to enter and act on cancer cell membranes. The peptide binds specifically to HDM-2 present on the surface of cancer cells, not normal cells. This binding leads to the formation of transmembrane pores, disrupting the cell membrane and causing cell lysis and necrosis, independent of the p53 pathway.
Peptide Information
| Property | Value |
|---|---|
| Peptide Sequence | Pro-Pro-Leu-Ser-Gln-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly |
| Molecular Formula | C188H293N53O44S |
| Molecular Weight | 4029.2 g/mol |
| CAS Number | 1159861-00-3 |
| Synonyms | H-PPLSQETFSDLWKLLKKWKMRRNQFWVKVQRG-OH, A6, Paralit |
Product Usage
THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug.
This product is for laboratory research purposes only. Not for human or animal consumption.
Safety Data Sheet
Full GHS 16-section Safety Data Sheet for PNC-27, prepared per OSHA HazCom 2012 (29 CFR 1910.1200). Includes substance identity, handling & storage, PPE, stability, transport and regulatory information.
CAS No.
1159861-00-3
Formula
C₁₈₈H₂₉₃N₅₃O₄₄S
Mol. Weight
4031.73 g/mol
Classification
Not hazardous (GHS)
Questions & answers
PNC-27 frequently asked questions
High Quality · 99% Purity Guaranteed
Product Quality Guarantee
We are continuously conducting HPLC testing on all of our raw powders as well as our finished products to ensure the quality of what we ship. You can have the product you bought from us independently tested at any HPLC-licensed testing facility, and if the results come back negative, we will refund the following:
HPLC Test Fee
$100
Plus a full refund
Total order amount + shipping
For laboratory research use only. Not for human or animal consumption.