PNC-27
Research-Grade Peptide · 99%+ Purity · COA Certified
Made in the USA
Ships from the USA
Research-Grade Peptide · 99%+ Purity · COA Certified
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For research use only. Not for human or animal consumption.
Certificate of Analysis
Independently 8× tested by ILS Laboratories and/or Kovera Labs.
99.47%
Purity
Passed full QC panel
Full QC panel
8× tested
ISO/IEC 17025 Accredited
All certificates are issued by independent ISO-accredited laboratories. Lot-specific documents are made available to qualified research professionals on request.
Full GHS 16-section Safety Data Sheet for PNC-27, prepared per OSHA HazCom 2012 (29 CFR 1910.1200). Includes substance identity, handling & storage, PPE, stability, transport and regulatory information.
CAS No.
Not assigned
Formula
Not assigned
Mol. Weight
Per COA
Classification
Not hazardous (GHS)
PNC-27 – Membrane-Active Anticancer Research Peptide
PNC-27 is a membrane-active peptide for in vitro anticancer research applications that selectively kills cancer cells by binding to HDM-2 on their membranes and inducing necrosis through pore formation.
Product Description
PNC-27 is a synthetic peptide designed to selectively kill cancer cells by targeting a protein called HDM-2 (also known as MDM2) found on the membranes of many cancer cells. It works by binding to membrane-bound HDM-2, forming pores in the cancer cell membrane, and causing rapid cell death through necrosis, while sparing normal cells.
PNC-27 is derived from the p53 protein's HDM-2 binding domain (amino acids 12-26) and is linked to a membrane-penetrating sequence, allowing it to enter and act on cancer cell membranes. The peptide binds specifically to HDM-2 present on the surface of cancer cells, not normal cells. This binding leads to the formation of transmembrane pores, disrupting the cell membrane and causing cell lysis and necrosis, independent of the p53 pathway.
Peptide Information
| Property | Value |
|---|---|
| Peptide Sequence | Pro-Pro-Leu-Ser-Gln-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly |
| Molecular Formula | C188H293N53O44S |
| Molecular Weight | 4029.2 g/mol |
| CAS Number | 1159861-00-3 |
| Synonyms | H-PPLSQETFSDLWKLLKKWKMRRNQFWVKVQRG-OH, A6, Paralit |
Product Usage
THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug.
This product is for laboratory research purposes only. Not for human or animal consumption.
Purity (HPLC)
≥99%
Application
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Testing
Third Party Tested
Manufacture
USA
99%+ HPLC Purity
Independently verified by accredited US laboratory
Endotoxin-Screened
LAL tested, LPS-free, endotoxin report available
GMP-Certified Manufacturing
USA facility, ISO 9001:2015
Lyophilized for Stability
Shipped cold-packed, intact for reconstitution
Investigated for selectively binding membrane-bound HDM-2 on cancer cells and inducing necrosis through transmembrane pore formation, independent of the p53 pathway.
For research use only — not for human or animal consumption.
Reconstitute
Reconstitute with bacteriostatic water for safe, accurate solvation before assay preparation.
Store Properly
Refrigerate the reconstituted solution at 2–8°C and use within 30 days for best stability.
Document Research
Log batch number, concentration and research notes per your laboratory protocol.
High Quality — 99% Purity Guaranteed
Product Quality Guarantee
We are continuously conducting HPLC testing on all of our raw powders as well as our finished products to ensure the quality of what we ship. You can have the product you bought from us independently tested at any HPLC-licensed testing facility — and if the results come back negative, we will refund the following:
HPLC Test Fee
$100
Plus a full refund
Total order amount + shipping