When sourcing analytical-grade bioregulators online, research institutions require verifiable purity, lot-specific documentation, and strict quality control. Epitalon (Epithalon) is a synthetic tetrapeptide widely evaluated in preclinical models for telomerase activation, telomere maintenance, and pineal gland regulation. PX1 Research supplies high-purity Epitalon reference standards manufactured in USA-based, GMP-compliant facilities for in vitro and laboratory research applications.
When sourcing analytical-grade bioregulators online, research institutions require verifiable purity, lot-specific documentation, and strict quality control. Epitalon (Epithalon) is a synthetic tetrapeptide widely evaluated in preclinical models for telomerase activation, telomere maintenance, and pineal gland regulation. PX1 Research supplies high-purity Epitalon reference standards manufactured in USA-based, GMP-compliant facilities for in vitro and laboratory research applications.
To order or bestellen Epitalon peptide online for verified laboratory applications, principal investigators must ensure their supplier delivers authenticated, high-purity synthetic sequences backed by comprehensive analytical data. Epitalon is a synthetic short-chain bioregulator peptide (Ala-Glu-Asp-Gly) designed to mimic the endogenous activity of pineal gland peptides. In preclinical research settings, obtaining reliable reference standards with explicit batch traceability is fundamental to generating reproducible experimental outcomes.
PX1 Research provides researchers access to HPLC-verified Epitalon manufactured in ISO 17025 accredited and GMP-compliant domestic facilities. Every batch undergoes rigorous quality assurance to eliminate counter-ion contaminants, heavy metals, and bacterial endotoxins, ensuring that assays investigating genomic stability, cellular senescence, and pineal gene expression remain unconfounded by vehicle impurities. Researchers seeking verified synthetic compounds can review our catalog of research peptides to support standardized in vitro protocols.
Epitalon (CAS Number 307297-39-8) is a synthetic tetrapeptide with the amino acid sequence L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-glycine ($C_{14}H_{22}N_{4}O_{9}$). Characterized by a molecular mass of approximately 390.35 g/mol, Epitalon belongs to the short-chain peptide class known as peptide bioregulators. These low-molecular-weight sequences are capable of crossing nuclear membranes and interacting directly with specific chromosomal regions in preclinical models.
Due to its short sequence length, Epitalon exhibits unique chemical stability profile relative to larger polypeptide chains. However, maintaining peptide integrity requires precise lyophilization protocols. PX1 Research utilizes advanced freeze-drying procedures that preserve peptide structural conformation without requiring harmful chemical stabilizers. Qualified research facilities evaluating this bioregulator can access full analytical datasets via our epitalon product standard page.
The primary mechanism of Epitalon documented in preclinical literature centers on its interaction with the telomerase enzyme complex. Telomerase is a ribonucleoprotein reverse transcriptase that elongates repetitive telomeric DNA sequences (TTAGGG) at the terminal ends of eukaryotic chromosomes. Telomere shortening occurs progressively during mitotic cell division, serving as a molecular clock that ultimately triggers cellular senescence or apoptosis.
In vitro assays utilizing somatic cell cultures demonstrate that Epitalon exposure induces the expression of the catalytic subunit of telomerase (TERT). By promoting TERT gene transcription, Epitalon facilitates telomere elongation and delays the onset of replicative senescence in human somatic fibroblast models. Furthermore, preclinical chromatin studies indicate that Epitalon induces heterochromatin decondensation near the centromeric regions, suggesting a direct epigenetic role in regulating gene expression patterns associated with cellular longevity.
Beyond chromosomal interactions, Epitalon was originally synthesized to replicate the biological activity of Epithalamin, a crude pineal gland extract. The pineal gland plays a central role in orchestrating neuroendocrine activity and biological rhythms through the cyclic secretion of melatonin. Preclinical animal studies suggest that Epitalon acts directly on pineal tissue to normalize age-related declines in endogenous melatonin synthesis.
In rodent models subjected to altered light-dark cycles, administration of Epitalon restored physiological melatonin secretion rhythms and reduced oxidative stress markers within neuroendocrine tissue. Research indicates that Epitalon upregulates mRNA expression of key enzymes involved in melatonin biosynthesis, including arylalkylamine N-acetyltransferase (AANAT). Investigating these neuroendocrine pathways provides critical insights into how pineal bioregulators influence systemic physiological homeostasis in longevity models.
Epitalon belongs to a broader class of short-chain peptide bioregulators designed for target-specific nuclear gene expression. When evaluating bioregulatory mechanisms in vitro, researchers frequently contrast Epitalon with other tissue-specific synthetic peptides to evaluate differential transcriptomic activity across cellular pathways.
For example, while Epitalon targets telomerase expression and pineal regulation, thymalin bioregulator research focuses primarily on T-cell differentiation and thymic immune function. Similarly, pinealon research peptides are evaluated for neuroprotective effects and reactive oxygen species (ROS) suppression in neuronal cell cultures. Comparing these target-specific peptides helps investigators mapped localized tissue responses against broader genomic stabilization mechanisms. Further mechanistic details on bioregulatory cascades are available in our open-access peptide research library.
Proper handling and reconstitution protocols are vital to maintain the structural stability and bioactivity of synthetic Epitalon in experimental setups. Lyophilized Epitalon powder should be stored upon receipt at -20°C or -80°C in a desiccated environment to prevent moisture condensation and enzymatic degradation.
For reconstitution, laboratory technicians should utilize sterile bacteriostatic water or sterile phosphate-buffered saline (PBS, pH 7.4), depending on the requirements of the intended assay. Reconstitution should be performed by gently introducing the solvent along the inner glass vial wall, followed by light swirling. Mechanical agitation, vigorous shaking, or vortexing must be avoided to prevent peptide shear stress. Post-reconstitution, liquid aliquots should be stored at 4°C for immediate short-term use (under 7 days) or stored in single-use aliquots at -80°C to minimize freeze-thaw cycles.
To ensure reliable experimental results, research compounds must be supported by rigorous third-party analytical testing. PX1 Research enforces strict quality assurance protocols on every production lot, verifying chemical purity and molecular identity prior to distribution.
Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) is performed to confirm peptide purity, ensuring the sample meets or exceeds a baseline purity target of 98.0%. Matrix-Assisted Laser Desorption/Ionization Time-of-Flight (MALDI-TOF) or Electrospray Ionization Mass Spectrometry (ESI-MS) confirms exact target molecular mass. Crucially, all lots undergo Chromogenic Recombinant Factor C (rFC) or Limulus Amebocyte Lysate (LAL) testing to ensure endotoxin levels remain strictly below laboratory assay thresholds (<0.01 EU/mg).
Evaluating supplier infrastructure is an essential step when deciding where to bestellen Epitalon peptide online. Off-shore suppliers frequently lack standardized lot traceability, exposing research facilities to product degradation, batch-to-batch inconsistency, and unverified filler ingredients.
PX1 Research operates exclusively within USA-based manufacturing facilities operating under strict Good Manufacturing Practices (GMP). All orders are fulfilled directly from state-of-the-art logistics hubs in California and Arizona, with same-day shipping offered Monday through Friday for orders placed before cutoff times. Institutional buyers seeking ongoing bulk allocations or specialized contract manufacturing can establish direct access via our wholesale laboratory portal.
What is Epitalon (Epithalon) used for in laboratory research?
Epitalon is a synthetic bioregulator tetrapeptide studied in preclinical research for its ability to activate telomerase enzyme expression, maintain telomere length, regulate melatonin synthesis, and reduce oxidative stress in cellular models.
How is Epitalon purity verified prior to shipment?
PX1 Research verifies Epitalon purity using Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) and mass spectrometry (ESI-MS/MALDI-TOF) conducted by independent ISO 17025 accredited laboratories. Every lot includes a downloadable Certificate of Analysis (COA).
What endotoxin standards apply to PX1 Research Epitalon?
All Epitalon lots undergo LAL or rFC endotoxin testing to guarantee levels remain below stringent research thresholds (<0.01 EU/mg), preventing confounding inflammatory responses in sensitive cell culture models.
How should lyophilized Epitalon be stored upon delivery?
Lyophilized Epitalon should be stored at -20°C or -80°C in a dry environment away from light. Under these conditions, the peptide remains stable for up to 24 months.
What solvent should be used to reconstitute Epitalon for in vitro studies?
Epitalon is readily soluble in aqueous solutions. Laboratory protocols typically utilize sterile bacteriostatic water, sterile 0.9% normal saline, or phosphate-buffered saline (PBS, pH 7.4) under laminar flow safety cabinets.
Can institutions establish direct wholesale accounts for bulk Epitalon orders?
Yes, universities, contract research organizations (CROs), and institutional laboratories can set up dedicated accounts for bulk purchasing, recurring batch supply, and custom vial configurations via the PX1 Research wholesale portal.
What is the difference between Epitalon and Epithalamin?
Epithalamin is a crude, natural peptide extract derived from bovine pineal glands, whereas Epitalon is a defined, synthetic tetrapeptide (Ala-Glu-Asp-Gly) created to reproduce the core biological activity of Epithalamin with higher molecular purity and reproducibility.
What shipping options are available for laboratory research orders?
PX1 Research ships all peptide orders from domestic fulfillment centers in California and Arizona. Orders placed Monday through Friday before 3:00 PM EST qualify for same-day dispatch with temperature-monitored packaging.
All products are sold strictly for laboratory and research use only. Not for human or veterinary use, diagnosis, treatment or consumption. Statements have not been evaluated by the FDA.