High-purity Vilon (Lys-Glu) is available from PX1 Research for qualified laboratory investigators evaluating cellular repair, epigenetic regulation, and tissue recovery in preclinical models of ionizing radiation exposure. Supplied strictly as a lyophilized research reagent, each lot is backed by rigorous third-party analytical testing to ensure maximum reproducibility in your experimental workflows.
High-purity Vilon (Lys-Glu) is available from PX1 Research for qualified laboratory investigators evaluating cellular repair, epigenetic regulation, and tissue recovery in preclinical models of ionizing radiation exposure. Supplied strictly as a lyophilized research reagent, each lot is backed by rigorous third-party analytical testing to ensure maximum reproducibility in your experimental workflows.
To buy Vilon for radiation recovery research, procurement officers and principal investigators require pure, verified Lys-Glu (Lysyl-Glutamic acid) dipeptide free from salt contaminants and endotoxins. PX1 Research supplies laboratory-grade Vilon manufactured in USA-based facilities, accompanied by lot-specific high-performance liquid chromatography (HPLC) and mass spectrometry (MS) certificates of analysis (COA) confirming chemical purity above 98%.
Vilon is categorized exclusively as a synthetic peptide bioregulator for in vitro assay systems and preclinical animal models. Investigators exploring post-irradiation cellular resilience, chromatin decondensation, or immune system modulation can access reference-grade compounds directly through our centralized research peptides hub. All orders ship directly from our ISO-compliant fulfillment nodes in California and Arizona with same-day dispatch for orders placed before standard cutoff times.
Vilon is a synthetic short-chain dipeptide composed of L-lysine and L-glutamic acid (H-Lys-Glu-OH). Originally derived from computational modeling of thymic peptide extracts, Vilon belongs to the class of peptide bioregulators pioneered to investigate sequence-specific interactions with genomic DNA. At the molecular level, preclinical studies suggest that ultrashort peptides like Lys-Glu enter the nucleus and bind directly to the major and minor grooves of double-stranded DNA.
This nuclear translocation enables Vilon to modulate gene expression without altering the primary nucleotide sequence. In vitro assays demonstrate that Lys-Glu induces targeted chromatin structural changes—specifically promoting the decondensation of heterochromatin into euchromatin in aging or damaged cell cultures. By altering chromatin accessibility, Vilon enhances the transcriptional activity of genes associated with ribosomal RNA synthesis, protein translation, and endogenous antioxidant enzyme production. Researchers examining nuclear architecture often cross-reference these mechanisms in our detailed guide on vilon bioregulator mechanism.
Ionizing radiation poses severe challenges to biological systems by inducing double-strand DNA breaks, generating reactive oxygen species (ROS), and triggering acute hematopoietic suppression. Preclinical rodent models subjected to sub-lethal and lethal doses of gamma radiation have been utilized to evaluate the radioprotective and regenerative properties of Lys-Glu. In these published animal studies, administration of synthetic Vilon prior to or immediately following radiation exposure demonstrated a statistically significant reduction in chromosome aberration frequency within bone marrow cells.
Furthermore, in vitro assays involving irradiated human lymphocyte cultures revealed that Vilon exposure mitigated radiation-induced apoptosis and restored mitotic activity. Researchers observed an upregulation of anti-apoptotic markers alongside normalized interleukin-2 (IL-2) expression in irradiated T-lymphocyte populations. These findings indicate that Vilon may serve as a critical reference agent for studying radiation mitigation, tissue-specific radioprotection, and post-irradiation immune reconstitutions.
When designing assays to measure post-radiation cellular recovery or immunomodulatory cascades, investigators frequently compare Vilon against other short-chain peptide bioregulators. While Vilon (Lys-Glu) focuses heavily on chromatin reactivation and lymphocyte function, Epitalon (Ala-Glu-Asp-Gly) is predominantly evaluated for its ability to induce telomerase activity and extend cellular Hayflick limits in senescence models.
Similarly, Thymogen (Glu-Trp) shares structural homology as a dipeptide derived from thymic research but exhibits distinct receptor-binding profiles that favor T-cell differentiation over generalized heterochromatin decondensation. In studies requiring broad tissue-repair assessments alongside radioprotection, researchers may also integrate tissue-regenerative peptides like BPC-157 to observe synergistic physiological responses across diverse cell lineages. Understanding these distinct pathways allows laboratories to select the exact target molecule required for their specific experimental parameters.
To preserve the structural integrity and bioactivity of Vilon in laboratory settings, strict storage and handling standards must be maintained. Reagent-grade Vilon is supplied as a sterile, lyophilized white powder in sealed glass vials. Upon receipt, lyophilized vials should be stored at -20°C for long-term stability, protected from direct light and moisture ingress. Prior to reconstitution, vials should be allowed to equilibrate to room temperature to prevent condensation within the container.
For reconstitution, laboratory technicians should use sterile bacteriostatic water or phosphate-buffered saline (PBS, pH 7.4) depending on downstream assay requirements. Gentle swirl mixing is recommended; aggressive vortexing or sonication should be avoided to prevent peptide aggregation. Once solubilized, liquid aliquots should be stored at 2°C to 8°C for immediate use (within 3–7 days) or stored frozen at -80°C to avoid repeated freeze-thaw cycles. Detailed step-by-step reconstitution mathematical formulas and vehicle selection criteria can be reviewed in our comprehensive peptide reconstitution guide.
Given the precise nature of epigenetic and radioprotective research, chemical purity and batch consistency are paramount. Low-quality peptide preparations containing truncated sequences, heavy metal residues, or high endotoxin levels introduce unquantifiable variables that invalidate experimental data. Qualified research suppliers must provide transparent, lot-specific analytical verification for every batch of Vilon.
PX1 Research subjects every synthesis lot to rigorous quality control assays. Chemical purity is verified using Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC), ensuring an analytical purity threshold of ≥98%. Molecular mass and sequence identity are confirmed using Liquid Chromatography-Mass Spectrometry (LC-MS). Additionally, total bacterial endotoxin levels are quantified via Chromogenic Limulus Amebocyte Lysate (LAL) testing, guaranteeing endotoxin levels strictly below 0.5 EU/mg—a critical parameter for sensitive cell culture and animal model applications.
PX1 Research operates strictly as a USA-based manufacturer and distributor of high-purity research compounds. Our production workflows adhere to Good Manufacturing Practice (GMP) guidelines within modern, controlled cleanroom environments. We partner exclusively with ISO 17025 accredited analytical testing laboratories to perform unbiased, third-party verification of our entire inventory.
Every product batch is assigned a unique lot number linked to its raw analytical data. Principal investigators can download public certificates of analysis directly from our repository to verify HPLC chromatograms and mass spectra prior to starting experimental trials. By maintaining full supply chain transparency and shipping directly from domestic warehouses in California and Arizona, PX1 Research eliminates international customs delays and guarantees cold-chain integrity during transit.
In modern biochemical laboratories, Vilon serves as a versatile tool across multiple analytical platforms. In chromatin immunoprecipitation (ChIP) and assay for transposase-accessible chromatin using sequencing (ATAC-seq), Lys-Glu is used to study local genome accessibility and histone acetylation modifications in damaged cellular lines.
Researchers also utilize Vilon in high-throughput cell viability assays (such as MTT or XTT assays) to quantify survival rates of epithelial, endothelial, or hematopoietic stem cells exposed to targeted doses of gamma or X-ray radiation. Evaluating the rate of single- and double-strand DNA repair via neutral comet assays or gamma-H2AX foci staining provides quantitative metrics on Vilon's role in accelerating enzymatic repair complexes.
Securing reliable quantities of research peptides for long-term study protocols requires streamlined institutional procurement. PX1 Research facilitates seamless ordering for university departments, contract research organizations (CROs), and private biotechnology facilities. Whether acquiring analytical reference standards or scaling up for multi-phase animal studies, our platform provides complete lot traceability and standard billing workflows.
Laboratories requiring high-volume orders or recurring delivery schedules can access dedicated account services and volume pricing structures through our institutional procurement desk at /wholesale. Our technical support team consists of knowledgeable specialists ready to assist with lot reservation, documentation verification, and specialized shipping requirements to support uninterrupted research.
What is Vilon and what is its molecular structure?
Vilon is a synthetic short-chain bioregulator dipeptide composed of L-lysine and L-glutamic acid (Lys-Glu). It has a molecular formula of C11H21N3O5 and a molecular weight of approximately 275.3 g/mol.
How is Vilon utilized in radiation recovery research?
In preclinical research, Vilon is studied for its ability to reduce chromatin condensation, lower radiation-induced double-strand DNA break markers, restore mitotic activity in irradiated cells, and modulate immune markers such as IL-2.
What purity levels are guaranteed for PX1 Research Vilon?
PX1 Research guarantees that all Vilon batches meet or exceed a chemical purity threshold of 98% as verified by Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) and Mass Spectrometry (LC-MS).
What are the endotoxin limits for research-grade Vilon?
All Vilon supplied by PX1 Research undergoes Chromogenic LAL testing to ensure endotoxin levels remain below 0.5 EU/mg, making it suitable for sensitive in vitro assays and animal model protocols.
How should lyophilized Vilon be stored upon arrival?
Lyophilized Vilon should be stored at -20°C for long-term stability. Once reconstituted in sterile solvent, liquid aliquots should be kept at 2°C to 8°C for short-term use or frozen at -80°C to avoid freeze-thaw degradation.
Can Vilon be ordered in bulk for institutional research projects?
Yes, PX1 Research offers institutional procurement, batch reservation, and volume tiers for academic and commercial laboratories via our wholesale portal.
How does Vilon differ from Epitalon?
While both are synthetic short-chain bioregulators, Vilon is a dipeptide (Lys-Glu) primarily evaluated for chromatin decondensation and immune cell repair, whereas Epitalon is a tetrapeptide (Ala-Glu-Asp-Gly) studied for telomerase activation.
Is Vilon approved for human clinical use or therapy?
No. Vilon supplied by PX1 Research is strictly designated for laboratory research use only (RUO) and in vitro or preclinical animal studies. It is not intended for human consumption, diagnostic, or therapeutic use.
All products are sold strictly for laboratory and research use only. Not for human or veterinary use, diagnosis, treatment or consumption. Statements have not been evaluated by the FDA.