Epitalon For Sale

Sourcing Epitalon for Sale: Direct Answer for Laboratory Researchers

When evaluating vendors with Epitalon for sale, research institutions require reference-grade material supported by comprehensive, lot-specific analytical documentation. Epitalon (L-alanyl-L-glutamyl-L-aspartyl-glycine) is a synthetic tetrapeptide classified as a pineal bioregulator. PX1 Research provides USA-manufactured Epitalon at ≥98% purity verified through Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) and Electrospray Ionization Mass Spectrometry (ESI-MS), accompanied by lot-specific Certificates of Analysis (COAs) and endotoxin testing.

To maintain rigorous scientific standards, researchers must avoid unverified suppliers offering material without batch-level testing. All research compounds supplied by PX1 Research are synthesized in GMP-compliant, ISO 17025-accredited facilities and intended strictly for in vitro assays, biochemical evaluations, and non-human preclinical models.

Molecular Structure and Classification of Epitalon

Epitalon (CAS 307297-39-8) is a synthetic short-chain peptide consisting of four amino acid residues: Ala-Glu-Asp-Gly (AEDG). With a molecular formula of C16H26N4O10 and a molecular weight of approximately 434.40 g/mol, it was designed as a synthetic analog of epithalamin, a peptide fraction originally isolated from bovine pineal gland extract.

As part of the broader class of bioregulator peptides, Epitalon demonstrates high target selectivity due to its minimal molecular weight and low steric hindrance. These structural parameters facilitate direct interaction with nuclear chromatin and promoter regions in cellular research models. Researchers exploring catalog options across all peptides frequently evaluate Epitalon for its distinct biochemical interaction profile compared to larger polypeptide sequences.

Mechanism of Action: Telomerase Activation and Telomere Maintenance

Preclinical literature indicates that the primary biochemical target of Epitalon involves the transcriptional regulation of the human telomerase reverse transcriptase (hTERT) gene. In human somatic cell cultures, exposure to Epitalon has been observed to induce telomerase activity, promoting the elongation of telomeric repeats at the terminal ends of chromosomes.

In vitro data suggest that Epitalon induces chromatin decondensation by interacting directly with histone proteins and DNA site-specific sequences. By facilitating transcription factor access to the hTERT promoter region, Epitalon serves as a primary model for investigating cellular senescence, telomere attrition, and replicative capacity in non-human experimental systems. Further mechanistic breakdowns are documented across our broader research library.

Preclinical Applications in Longevity and Circadian Rhythms

In addition to telomerase expression, Epitalon is widely investigated for its pineal-modulating characteristics. Preclinical rodent models demonstrate that administration of Epitalon can restore nocturnal melatonin secretion in aging subjects, suggesting an regulatory role in pineal gland gene expression and neuroendocrine regulation.

In animal studies examining circadian biology, Epitalon exposure has been associated with normalized antioxidant enzyme activity, such as superoxide dismutase (SOD) and glutathione peroxidase (GPx), alongside reduced accumulation of lipid peroxidation markers. These findings position Epitalon as a valuable tool for researching circadian rhythm synchronization, oxidative stress modulation, and systemic aging markers.

Comparative Analysis: Epitalon vs. Other Bioregulator Peptides

Within bioregulator research, scientists often compare Epitalon against other targeted short-chain peptides to map tissue-specific gene expression. For example, while Epitalon acts predominantly on pineal and telomeric pathways, Thymalin targets thymic tissue pathways regulating cell-mediated immune responses. Similarly, researchers investigating tissue repair models alongside longevity markers often utilize BPC-157 for cellular signaling studies. For comprehensive pineal research, scientists evaluate primary reference standards like Epitalon 10mg alongside the general Epitalon monograph to establish control baselines.

Analytical Quality Control: RP-HPLC and Mass Spectrometry

Ensuring experimental reproducibility requires that every batch of Epitalon for sale meets strict purity and identity metrics. PX1 Research subjects all peptide lots to dual-stage analytical verification:

1. Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC): Determines chemical purity by separating the target peptide from synthesis byproducts, truncated sequences, and residual reagents. PX1 Research guarantees a minimum purity threshold of ≥98%. 2. Electrospray Ionization Mass Spectrometry (ESI-MS): Confirms exact molecular mass (434.40 Da) to verify sequence accuracy and ensure the complete absence of heavy metal contamination or major molecular adducts.

Every shipment includes a lot-specific Certificate of Analysis detailing exact chromatographic retention times and spectral mass matches.

Endotoxin Testing and Bio-Burden Specifications

Bacterial endotoxins (lipopolysaccharides) introduce significant confounding variables in cell culture assays and preclinical animal experiments, potentially triggering unwanted inflammatory cascades or cell toxicity. PX1 Research performs rigorous Limulus Amebocyte Lysate (LAL) testing on all Epitalon lots.

Our threshold limits mandate <0.01 EU/mg, ensuring that researchers receive ultra-pure compound free of microbial contamination, bio-burden, or exogenous pyrogens. This level of quality control is essential for maintaining valid baseline data in sensitive in vitro and in vivo research protocols.

Reconstitution and Handling Protocols for Laboratory Use

Epitalon is supplied as a lyophilized (freeze-dried) sterile powder in sealed glass vials. To preserve peptide integrity prior to experimental use, researchers should follow standardized laboratory handling procedures:

Reconstitution: Reconstitute lyophilized powder using sterile Bacteriostatic Water or laboratory-grade Phosphate-Buffered Saline (PBS). Gently swirl the vial until the solute is completely dissolved; avoid aggressive vortexing to prevent mechanical shear stress on the peptide backbone. Storage: Store un-reconstituted lyophilized vials in a dark, dry environment at -20°C for up to 24 months. Following reconstitution, store liquid aliquots at 2°C to 8°C for short-term use (up to 30 days) or freeze at -80°C to avoid repeated freeze-thaw cycles.

USA Manufacturing, Lot Traceability, and Shipping

PX1 Research operates within domestic, GMP-compliant facilities in the United States. Every production run undergoes complete lot indexing, enabling full backward traceability from raw amino acid coupling through final sterile filtration and lyophilization.

To protect temperature-sensitive peptides from environmental degradation, orders are processed with expedited fulfillment. Orders placed Monday through Friday ship same-day from our primary logistics hubs in California and Arizona. Academic and institutional buyers seeking bulk quantities or dedicated supply agreements can access specialized procurement via our wholesale portal.