A 10mg vial of lyophilized Selank provides a high-yield, high-purity unit engineered for high-throughput in vitro assays, receptor-binding studies, and preclinical rodent models. This technical guide outlines the physicochemical properties, precise reconstitution calculations, lot-specific analytical validation, and storage parameters required for laboratory research. Evaluated under strict laboratory protocols, PX1 Research supplies high-purity peptides to support reliable, reproducible experimental outcomes.
A 10mg vial of lyophilized Selank provides a high-yield, high-purity unit engineered for high-throughput in vitro assays, receptor-binding studies, and preclinical rodent models. This technical guide outlines the physicochemical properties, precise reconstitution calculations, lot-specific analytical validation, and storage parameters required for laboratory research. Evaluated under strict laboratory protocols, PX1 Research supplies high-purity peptides to support reliable, reproducible experimental outcomes.
The 10mg Selank vial is a high-capacity format optimized for academic laboratories, biotechnology firms, and institutional researchers who conduct multi-trial studies or require consistent stock solutions across repeated assay runs. Containing 10 milligrams of synthetic, highly purified heptapeptide as a lyophilized white powder, this vial format minimizes lot-to-lot variance across extended experimental timelines.
Investigators who select the Selank 10mg format typically utilize it for high-volume in vitro screenings, microdialysis studies in preclinical rodent models, or high-throughput enzymatic stability testing. By consolidating 10 milligrams of active sequence into a single sealed, argon-purged glass vial, research facilities reduce packaging waste and lower shipping frequency while ensuring uniform concentration parameters across large experimental blocks. If your laboratory protocols require alternative quantities or broader comparative screens, browse our catalog of all peptides for complementary neurochemical tools.
Selank is a synthetic analog of the naturally occurring human immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg), elongated at the C-terminus with a Pro-Gly-Pro tripeptide sequence. Its complete amino acid sequence is Thr-Lys-Pro-Arg-Pro-Gly-Pro (molecular formula: C33H57N11O9, molecular weight: 751.9 g/mol). The addition of the C-terminal Pro-Gly-Pro tripeptide significantly enhances metabolic stability against vascular and tissue peptidases, extending its half-life in physiological buffered solutions compared to native tuftsin.
Preclinical studies suggest that Selank modulates central neurotransmission through multiple target pathways. In vitro binding assays and animal tissue models demonstrate that Selank influences the GABAergic system by modulating allosteric binding sites on the GABA-A receptor complex, altering affinity without acting as a direct receptor agonist. Additionally, preclinical investigations indicate that Selank upregulates mRNA expression of Brain-Derived Neurotrophic Factor (BDNF) in hippocampal tissue and modulates monoamine metabolism, particularly serotonin and dopamine turnover rates. Researchers interested in broader central nervous system signaling pathways can explore detailed mechanisms in our research library.
Accurate reconstitution of a 10mg lyophilized cake requires precise liquid volumetric math to establish targeted working stock concentrations. Researchers should use sterile, laboratory-grade bacteriostatic water (0.9% benzyl alcohol) for multi-use working vials or sterile 0.9% Sodium Chloride / Phosphate-Buffered Saline (PBS) for immediate single-use cell culture assays.
Below are the baseline concentration calculations when reconstituting a 10mg Selank vial with standard diluent volumes:
1.0 mL Diluent Addition: 10 mg / 1.0 mL = 10.0 mg/mL concentration (10,000 µg/mL). A 10 µL micro-pipetted aliquot yields exactly 100 µg of active compound.
2.0 mL Diluent Addition: 10 mg / 2.0 mL = 5.0 mg/mL concentration (5,000 µg/mL). A 10 µL micro-pipetted aliquot yields exactly 50 µg of active compound.
3.0 mL Diluent Addition: 10 mg / 3.0 mL = 3.33 mg/mL concentration (3,333 µg/mL). A 10 µL micro-pipetted aliquot yields exactly 33.3 µg of active compound.
When introducing diluent into the glass vial, direct the fluid stream down the inside glass wall rather than directly onto the lyophilized cake to prevent shear stress and foaming. Gently swirl the vial until the cake is completely dissolved; never vortex neuropeptides. For rapid calculations involving customized working volumes or specific target microgram delivery, utilize our online reconstitution calculator.
Lyophilized Selank stored at -20°C or -80°C in a dry, dark environment remains stable for up to 24 months. Once reconstituted, the aqueous peptide solution becomes susceptible to enzymatic degradation, hydrolysis, and temperature-induced conformational changes. To maximize chemical integrity, researchers must adhere to strict climate control protocols.
Reconstituted working solutions using bacteriostatic water maintain stability at 2°C to 8°C for up to 28 days. For long-term liquid storage or protocols requiring unpreserved diluents (such as sterile saline or PBS), the reconstituted solution must be aliquoted into sterile microcentrifuge tubes immediately after preparation. Avoid repeated freeze-thaw cycles, as ice crystal formation causes peptide shear and loss of functional concentration. Store master aliquots at -80°C for up to 6 months.
When designing neurobiological or immunological research models, investigators often compare Selank against other regulatory peptides in the same structural or functional class. Understanding these distinctions ensures selection of the appropriate compound for specific assay conditions.
In preclinical animal models, Selank is frequently evaluated alongside Semax, an ACTH(4-10) derivative that predominantly impacts neurotrophic signaling, cholinergic pathways, and vascular endothelial response. While Selank incorporates the C-terminal Pro-Gly-Pro motif derived from tuftsin to balance immune and GABAergic interactions, modifications such as N-Acetyl Semax Amidate focus on maximizing blood-brain barrier permeability and enzymatic resistance. While Semax variants primarily drive neuroplasticity and cognitive processing parameters in rodent studies, Selank uniquely modulates GABA-A receptor affinity alongside BDNF expression, making it a preferred subject for comparative neurochemical signaling assays.
PX1 Research enforces rigorous, multi-step quality control testing on every batch of Selank produced in our GMP-compliant, ISO 17025-accredited laboratory facilities. Every 10mg vial is issued with a lot-matched Certificate of Analysis detailing exact chemical metrics.
Purity Verification: Assessed via High-Performance Liquid Chromatography (HPLC) coupled with UV detection at 214 nm. PX1 Research guarantees a minimum purity threshold of 99.0%, ensuring raw synthesis impurities and truncated peptide fragments do not compromise assay baseline results.
Mass Identity Confirmation: Validated via Electrospray Ionization Mass Spectrometry (ESI-MS) to verify the theoretical molecular mass of 751.9 Da, confirming exact amino acid sequence construction.
Endotoxin Testing: Quantitative Chromogenic Reagent (LAL) testing performed per USP <85> standards to verify bacterial endotoxin levels remain below 0.5 EU/mg. This step is crucial for preventing non-specific inflammatory responses in cellular culture and animal models. Review lot data directly on our dedicated COA verification page.
Selecting the correct vial size depends entirely on trial duration, daily aliquot throughput, and diluent selection. While a 10mg vial provides maximum cost-efficiency and workflow uniformity for large experimental series, smaller or larger formats may better fit specialized lab requirements.
Smaller formats (such as 2mg or 5mg vials) are optimal for pilot studies, single-dose microdialysis runs, or assays where liquid storage beyond 48 hours must be avoided due to preservative-free media constraints. Conversely, high-volume research institutions requiring bulk quantities for long-term multi-animal cohorts can establish dedicated commercial procurement accounts via our wholesale portal. If PX1 Research does not currently display a specific non-standard vial size on the public store, our customer support team can assist institutional buyers with custom synthesis or alternative fill volumes.
PX1 Research operates strictly within the United States, utilizing state-of-the-art solid-phase peptide synthesis (SPPS) equipment, automated HPLC purification trains, and controlled cleanroom lyophilizating suites located in California and Arizona. Every stage of manufacturing adheres to stringent quality management frameworks.
By maintaining complete domestic control over synthesis, lyophilization, stopper crimping, and analytical testing, PX1 eliminates the cold-chain risks and purity degradation associated with unverified overseas sourcing. Orders placed before daily cutoff thresholds ship same-day from our CA and AZ logistics facilities, packed in thermal-buffered shipping materials to preserve peptide matrix integrity during transit.
What is the purity specification for PX1 Research Selank 10mg?
Every batch of Selank 10mg from PX1 Research is verified by HPLC and ESI-MS to meet or exceed a minimum purity threshold of 99.0%. Lot-specific Certificates of Analysis are publicly accessible for verification.
How should reconstituted Selank 10mg be stored in the laboratory?
Once reconstituted with bacteriostatic water, store the vial at 2°C to 8°C for up to 28 days. For long-term storage without preserved diluent, divide the solution into single-use aliquots in sterile microcentrifuge tubes and store at -80°C to prevent freeze-thaw degradation.
What is the molecular weight and sequence of Selank?
Selank is a synthetic heptapeptide with the chemical sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. It has a molecular formula of C33H57N11O9 and a monoisotopic molecular weight of 751.9 g/mol.
What diluent volume is recommended for a 10mg Selank vial?
Diluent volume depends on target working concentrations. Adding 1.0 mL creates a 10.0 mg/mL (10,000 µg/mL) concentration, 2.0 mL yields 5.0 mg/mL (5,000 µg/mL), and 3.0 mL yields 3.33 mg/mL (3,333 µg/mL). Use the PX1 reconstitution calculator to compute customized protocols.
What are the endotoxin limits for Selank 10mg research vials?
PX1 Research performs USP <85> Chromogenic LAL testing on every lot, guaranteeing endotoxin levels are strictly controlled below 0.5 EU/mg to prevent non-specific immune activation in in vitro and in vivo models.
Is Selank 10mg suitable for human administration or clinical use?
No. Selank 10mg is sold strictly as a research chemical compound for laboratory, in vitro, and preclinical research applications only. It is explicitly not for human, clinical, or veterinary use.
How does Selank compare to Semax in preclinical research models?
While both are synthetic peptides with C-terminal Pro-Gly-Pro stability sequences, Selank is derived from tuftsin and exhibits prominent GABAergic allosteric modulation and BDNF upregulation, whereas Semax is derived from ACTH(4-10) and primarily modulates melanocortin and cholinergic signaling pathways.
Where are PX1 Research Selank vials manufactured and shipped from?
All PX1 Research peptides are manufactured in USA-based ISO 17025 and GMP-compliant facilities. Orders are fulfilled and shipped directly from our logistics centers located in California and Arizona.
All products are sold strictly for laboratory and research use only. Not for human or veterinary use, diagnosis, treatment or consumption. Statements have not been evaluated by the FDA.