Looking to acquire verified reference standards for neurochemical or immunomodulatory assays? High-purity Selank peptide for sale from PX1 Research offers precise analytical consistency and verified sequence integrity for rigorous laboratory applications. All catalog compounds are supplied strictly as non-clinical research chemicals for in vitro and animal models.
Looking to acquire verified reference standards for neurochemical or immunomodulatory assays? High-purity Selank peptide for sale from PX1 Research offers precise analytical consistency and verified sequence integrity for rigorous laboratory applications. All catalog compounds are supplied strictly as non-clinical research chemicals for in vitro and animal models.
When evaluating Selank peptide for sale, laboratory researchers require high-purity, analytical-grade material backed by third-party verification. Selank is a synthetic heptapeptide derivative of the naturally occurring immunomodulatory peptide Tuftsin, engineered with a Pro-Gly-Pro C-terminal sequence for enhanced enzymatic stability. PX1 Research supplies USA-manufactured Selank exclusively for in vitro and preclinical research applications, complete with lot-specific HPLC and mass spectrometry data.
Researchers seeking to acquire Selank peptide must prioritize vendor transparency, batch traceability, and comprehensive purity testing. Substandard peptide preparations containing sequence truncated impurities or unreacted counter-ions can compromise experimental reproducibility in neurochemical and gene expression assays. At PX1 Research, every batch undergoes independent testing to ensure strictly quantified specifications prior to distribution.
Selank is a synthetic heptapeptide with the chemical sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TPKRPGP). Derived from the naturally occurring human tetrapeptide Tuftsin (Thr-Lys-Pro-Arg), Selank incorporates a tripeptide sequence (Pro-Gly-Pro) attached to its C-terminus. This structural addition significantly extends the peptide's half-life in biological substrates by conferring resistance to exopeptidases and carboxypeptidases.
With a molecular formula of C33H57N11O9 and a molecular weight of approximately 751.9 g/mol, Selank exhibits high solubility in aqueous buffer systems. In preclinical setups, the C-terminal elongation allows the peptide to maintain structural integrity during incubation in cellular media or blood plasma matrices. Understanding these biochemical properties is critical when designing quantitative assays in neurobiology and peptide degradation studies.
In vitro and rodent models have demonstrated that Selank exerts complex modulatory effects on both the central nervous system and immune system pathways. Preclinical literature indicates that Selank influences the expression of neurotrophic factors, most notably Brain-Derived Neurotrophic Factor (BDNF), in hippocampal cell cultures. Researchers investigating neuroplasticity often track changes in mRNA expression levels of BDNF and its primary receptor, TrkB, following peptide exposure.
Additionally, electrophysiological and receptor-binding assays show that Selank modulates GABAergic neurotransmission. Unlike traditional Allosteric GABA-A receptor agonists, Selank does not bind directly to the benzodiazepine site; instead, in vitro data indicate it alters the affinity of GABA receptors for their endogenous ligand via allosteric modulation. Concurrently, preclinical studies document alterations in monoamine metabolism, including shifts in serotonin (5-HT) and dopamine metabolite concentrations within specified brain regions.
Because Selank is derived from Tuftsin, its influence on immune system cell cultures represents a major area of preclinical investigation. In vitro studies involving splenocytes and peripheral blood mononuclear cells (PBMCs) demonstrate that Selank can modulate gene expression for key cytokines, including Interleukin-6 (IL-6), Interleukin-10 (IL-10), and Interferon-gamma (IFN-gamma).
Research models evaluating inflammatory stress responses report that Selank helps balance pro-inflammatory and anti-inflammatory signaling cascades. Investigating these dual neuro-immune mechanisms provides essential insights into how regulatory peptides bridge central nervous system activity and systemic immune regulation.
When designing comparative research protocols, investigators frequently analyze Selank alongside other synthetic regulatory peptides. A primary comparative compound is Semax, an ACTH(4-10) analog primarily studied for its neuroprotective and pro-cognitive mechanisms in rodent models. While Semax concentrates heavily on melanocortin receptor interactions and BDNF upregulation, Selank exhibits broader immunomodulatory features inherited from its Tuftsin derivative structure.
Another distinct analog in this category is N-Acetyl Selank Amidate, an acetylated and amidated variant designed for enhanced metabolic stability and lipophilicity in specific specialized cell membrane permeable assays. Researchers evaluating the full spectrum of regulatory compounds can browse our complete catalog of all research peptides to select the exact chemical parameters required for their experimental design.
To ensure reliable experimental outcomes, purchasing Selank peptide for sale requires strict verification of chemical purity and identity. PX1 Research subjects every single production lot to rigorous third-party testing at an ISO 17025 accredited laboratory. Each product page provides access to a lot-specific Certificate of Analysis (COA).
Purity is quantified using Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC), ensuring that the target peptide meets or exceeds a minimum 99% purity baseline. Mass Spectrometry (MS) analysis is performed simultaneously to confirm exact molecular weight and verify the absence of structural deletion sequences. Furthermore, Chromogenic Limulus Amebocyte Lysate (LAL) testing is conducted to measure bacterial endotoxin levels, guaranteeing low endotoxin concentrations suitable for sensitive biological assays.
Selank is supplied as a lyophilized (freeze-dried) powder to maximize shelf stability during transit and storage. For laboratory reconstitution, researchers typically utilize sterile Bacteriostatic Water (0.9% benzyl alcohol) or sterile phosphate-buffered saline (PBS, pH 7.4), depending on the requirements of the planned assay.
Standard laboratory protocol dictates allowing the vial to reach room temperature before adding the solvent to prevent condensation inside the container. Gentle swirling or slow inversion is recommended to dissolve the lyophilized cake; aggressive vortexing should be avoided as mechanical shear stress can denature delicate peptide chains. Detailed guidance on handling and preparing laboratory solutions can be found in our research library hub.
Maintaining chemical stability is essential for preserving sample integrity over extended experimental timelines. Lyophilized Selank peptide should be stored in a freezer at -20°C for long-term preservation, protected from light and moisture. Under these conditions, the un-reconstituted compound remains stable for up to 24 months.
Once reconstituted into liquid solution, the peptide should be aliquoted into single-use microcentrifuge tubes to prevent repeated freeze-thaw cycles, which degrade peptide bonds over time. Reconstituted aqueous solutions should be maintained at 2°C to 8°C and utilized within 30 days. For frozen liquid storage (-80°C), aliquots maintain stability for several months when properly sealed.
PX1 Research manufactures all research compounds within state-of-the-art facilities located in the United States operating under strict cGMP-compliant protocols. Standardized manufacturing controls eliminate batch-to-batch variability, providing research institutions with consistent reagents across multi-phase studies.
From raw material synthesis through final lyophilization and packaging, every step adheres to rigid quality metrics. Academic laboratories, biotechnology firms, and institutional buyers seeking volume supply or routine delivery schedules can set up institutional procurement options via our wholesale portal.
What is Selank peptide used for in laboratory research?
In laboratory research, Selank is used as a reference compound to investigate neuroplasticity, BDNF mRNA expression, GABAergic receptor modulations, and cytokine signaling balance in cell cultures and animal models.
How is the purity of Selank verified at PX1 Research?
Purity is verified using Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) to confirm purity levels exceeding 99%, combined with Mass Spectrometry (MS) for mass identification and LAL assays for endotoxin quantification.
What solvent should be used for reconstituting lyophilized Selank?
For standard laboratory setups, sterile Bacteriostatic Water or sterile Phosphate-Buffered Saline (PBS, pH 7.4) is typically used depending on the solubility requirements of the specific cell culture or assay protocol.
How should reconstituted Selank solutions be stored?
Reconstituted liquid solutions should be stored at 2°C to 8°C and used within 30 days. To store liquid solutions for longer periods, aliquot into single-use vials and store at -80°C to avoid repeated freeze-thaw cycles.
How does Selank differ structurally from naturally occurring Tuftsin?
Selank contains the full amino acid sequence of Tuftsin (Thr-Lys-Pro-Arg) with an added Pro-Gly-Pro (PGP) tripeptide attached to the C-terminus, which protects the molecule against enzymatic degradation.
Can Selank be used for human administration or clinical therapy?
No. All products sold by PX1 Research, including Selank, are strictly designated for laboratory research use only. They are not intended for human consumption, clinical treatment, or diagnostic applications.
What is the typical shipping timeline for Selank peptide orders?
PX1 Research dispatches orders same-day Monday through Friday from our fulfillment hubs in California and Arizona to minimize transit times and ensure prompt laboratory delivery.
Are batch-specific Certificates of Analysis (COAs) available?
Yes, every lot of Selank shipped by PX1 Research includes access to a lot-specific COA generated by an independent ISO 17025 accredited laboratory.
All products are sold strictly for laboratory and research use only. Not for human or veterinary use, diagnosis, treatment or consumption. Statements have not been evaluated by the FDA.