Summary
BPC-157 is a synthetic pentadecapeptide studied in growth-factor and angiogenesis models. TB-500 is a synthetic thymosin beta-4 fragment studied for actin sequestration and cell migration. Because the mechanisms differ, the two appear together in repair-model literature as complementary, not redundant, compounds.
BPC-157 vs TB-500 at a glance
| Attribute | BPC-157 | TB-500 |
|---|---|---|
| Origin | Synthetic fragment of a gastric-juice protein (Body Protection Compound) | Synthetic fragment of thymosin beta-4 |
| Length | 15 amino acids (pentadecapeptide) | Active region of a 43-amino-acid protein |
| Molecular weight | ~1419.5 g/mol | ~4963 g/mol |
| Primary mechanism studied | Growth-factor and nitric-oxide signalling, angiogenesis models | Actin sequestration, cell migration models |
| Reported half-life | Short (minutes in plasma) | Longer (~2–3 days reported) |
| Typical research focus | Tissue-repair and gastrointestinal models | Actin-binding, migration and repair models |
| PX1 purity standard | ≥99% HPLC + MS identity | ≥99% HPLC + MS identity |
Mechanism of action in research models
BPC-157
Investigated for interaction with growth-factor pathways (including VEGF signalling) and nitric-oxide systems in angiogenesis and gastrointestinal tissue models.
TB-500
Investigated for binding G-actin, which regulates actin polymerisation and is studied in cell-migration and wound-model assays.
Purity & documentation
Every PX1 lot of BPC-157 and TB-500 is USA-manufactured, verified at 99%+ by HPLC with mass-spectrometry identity, and shipped with a batch-specific Certificate of Analysis.
Frequently asked questions
What is the main difference between BPC-157 and TB-500?
BPC-157 is a 15-amino-acid gastric peptide fragment studied in growth-factor signalling models, while TB-500 is a thymosin beta-4 fragment studied for actin sequestration and cell migration. Their mechanisms are complementary rather than overlapping.
Why are BPC-157 and TB-500 studied together?
Because they act on different pathways, repair-model literature often pairs them to observe combined effects. PX1 supplies both individually and as the Wolverine blend (BPC-157 + TB-500).
Which has the longer half-life?
TB-500 has a markedly longer reported half-life (around 2–3 days) than BPC-157, whose plasma half-life is reported in minutes.
Are BPC-157 and TB-500 for human use?
No. PX1 Research supplies both compounds strictly for in-vitro laboratory research use only — not for human or veterinary use.
For in-vitro laboratory research use only. Not for human or veterinary use.