Nootropic Peptides in Cognitive Research: Semax, Selank, Dihexa & More
Cognitive-model literature is dominated by ACTH-derived and tuftsin-derived peptides plus a handful of small molecules. Specs, reported ranges and lot documentation for each compound.
By PX1 Research Team · August 4, 2026
Nootropic Peptides in Cognitive Research: Semax, Selank, Dihexa & More
Cognitive-model literature is dominated by ACTH-derived and tuftsin-derived peptides plus a handful of small molecules.
| Compound | Class | Lowest reported study amount | Vial sizes |
|---|---|---|---|
| Semax | ACTH(4-10) analog nootropic peptide | 300–600 mcg | 30 mg vial / 50 mg nasal |
| Selank | tuftsin analog heptapeptide | 250–500 mcg | 10 mg vial / 40 mg nasal |
| Dihexa | angiotensin IV derivative (HGF/c-Met modulator) | 5–10 mg | 10 mg vial / 10 mg capsules |
| Adamax | cyclic dipeptide nootropic (Noopept analog) | 300–500 mcg | 10 mg |
| DSIP | nonapeptide isolated from rabbit cerebral venous blood | 100–250 mcg | 5 mg |
Compound-by-compound notes
Semax
Semax is a ACTH(4-10) analog nootropic peptide studied in BDNF and cognitive-model research. Standard preparation is 30 mg + 3 mL = 10 mg/mL. Reported arms:
| Study arm | Reported amount | Cadence |
|---|---|---|
| Standard arm | 300–600 mcg | daily intranasal |
Product page: Semax.
Selank
Selank is a tuftsin analog heptapeptide studied in anxiolytic-pathway and GABA research. Standard preparation is 10 mg + 2 mL = 5 mg/mL. Reported arms:
| Study arm | Reported amount | Cadence |
|---|---|---|
| Standard arm | 250–500 mcg | daily intranasal |
Product page: Selank.
Dihexa
Dihexa is a angiotensin IV derivative (HGF/c-Met modulator) studied in synaptogenesis research. Standard preparation is 10 mg + 2 mL = 5 mg/mL. Reported arms:
| Study arm | Reported amount | Cadence |
|---|---|---|
| Standard arm | 5–10 mg | daily oral models |
Product page: Dihexa.
Adamax
Adamax is a cyclic dipeptide nootropic (Noopept analog) studied in BDNF/NGF cognitive research. Standard preparation is 10 mg + 2 mL = 5 mg/mL. Reported arms:
| Study arm | Reported amount | Cadence |
|---|---|---|
| Standard arm | 300–500 mcg | daily intranasal |
Product page: Adamax.
DSIP
DSIP is a nonapeptide isolated from rabbit cerebral venous blood studied in sleep-architecture research. Standard preparation is 5 mg + 2 mL = 2.5 mg/mL. Reported arms:
| Study arm | Reported amount | Cadence |
|---|---|---|
| Standard arm | 100–250 mcg | nightly |
Product page: DSIP.
How researchers evaluate material before running anything
Purity claims mean nothing without a lot-specific COA showing an HPLC chromatogram, LC-MS identity and endotoxin results. PX1 publishes all three at /coa.
How PX1 documents every lot
Every PX1 lot ships with HPLC purity, LC-MS identity, residual solvent, moisture (Karl Fischer), sterility and endotoxin data. Lot documentation is published at /purity-reports, /endotoxin-reports and /coa. Synthesis, purification, lyophilization and vial fill happen in U.S. facilities — see /manufacturing-process.
Research use only. PX1 Research supplies compounds for laboratory and in-vitro research. Nothing here is medical advice, a dosing recommendation, or an offer for human or veterinary use. Figures cited are reported from published laboratory literature.