Mitochondrial Peptides: SS-31, MOTS-c and NAD+
Three compounds, three different levels of mitochondrial biology. Specs, reported ranges and lot documentation for each compound.
By PX1 Research Team · August 4, 2026
Mitochondrial Peptides: SS-31, MOTS-c and NAD+
Three compounds, three different levels of mitochondrial biology.
| Compound | Class | Lowest reported study amount | Vial sizes |
|---|---|---|---|
| SS-31 (Elamipretide) | mitochondria-targeting tetrapeptide (cardiolipin binder) | 5 mg | 10 mg / 50 mg |
| MOTS-c | mitochondrial-derived peptide (16 aa) | 5 mg | 10 mg |
| NAD+ | nicotinamide adenine dinucleotide cofactor | 50 mg | 100 mg / 500 mg |
Compound-by-compound notes
SS-31 (Elamipretide)
SS-31 (Elamipretide) is a mitochondria-targeting tetrapeptide (cardiolipin binder) studied in cardiolipin and mitochondrial-bioenergetics research. Standard preparation is 50 mg + 5 mL = 10 mg/mL. Reported arms:
| Study arm | Reported amount | Cadence |
|---|---|---|
| Standard arm | 5 mg | daily |
| Extended arm | 10 mg | every other day |
Product page: SS-31 (Elamipretide).
MOTS-c
MOTS-c is a mitochondrial-derived peptide (16 aa) studied in mitochondrial metabolism and AMPK-pathway research. Standard preparation is 10 mg + 2 mL = 5 mg/mL. Reported arms:
| Study arm | Reported amount | Cadence |
|---|---|---|
| Standard arm | 5 mg | 2–3× weekly |
| Extended arm | 10 mg | weekly |
Product page: MOTS-c.
NAD+
NAD+ is a nicotinamide adenine dinucleotide cofactor studied in sirtuin and NAD-salvage-pathway research. Standard preparation is 500 mg + 5 mL = 100 mg/mL. Reported arms:
| Study arm | Reported amount | Cadence |
|---|---|---|
| Low arm | 50 mg | daily |
| Mid arm | 100 mg | daily |
| High arm | 250–500 mg | weekly infusion models |
Product page: NAD+.
How researchers evaluate material before running anything
Purity claims mean nothing without a lot-specific COA showing an HPLC chromatogram, LC-MS identity and endotoxin results. PX1 publishes all three at /coa.
How PX1 documents every lot
Every PX1 lot ships with HPLC purity, LC-MS identity, residual solvent, moisture (Karl Fischer), sterility and endotoxin data. Lot documentation is published at /purity-reports, /endotoxin-reports and /coa. Synthesis, purification, lyophilization and vial fill happen in U.S. facilities — see /manufacturing-process.
Research use only. PX1 Research supplies compounds for laboratory and in-vitro research. Nothing here is medical advice, a dosing recommendation, or an offer for human or veterinary use. Figures cited are reported from published laboratory literature.