BPC-157 vs TB-500 (Thymosin Beta-4): Mechanism, Specs & Reported Ranges Compared
Side-by-side comparison of BPC-157 and TB-500 (Thymosin Beta-4) — receptor mechanism, half-life, vial sizes, reconstitution and reported study arms.
By PX1 Research Team · August 4, 2026
BPC-157 vs TB-500 (Thymosin Beta-4) at a glance
| BPC-157 | TB-500 (Thymosin Beta-4) | |
|---|---|---|
| Class | synthetic pentadecapeptide derived from gastric juice protein BPC | synthetic fragment of thymosin beta-4 |
| Reported half-life | short (minutes in plasma) | ~2–3 days |
| Vial sizes | 5 mg / 10 mg | 10 mg |
| Typical reconstitution | 5 mg + 2 mL = 2.5 mg/mL (250 mcg = 10 units) | 10 mg + 2 mL = 5 mg/mL |
| Research focus | tissue-repair and gastrointestinal models | actin-binding and repair-model research |
Mechanistic difference
BPC-157 is a gastric-juice-derived pentadecapeptide; TB-500 is a thymosin beta-4 fragment acting on actin sequestration. They appear together in repair-model literature because the mechanisms are complementary, not redundant.
Reported study ranges side by side
BPC-157
| Study arm | Reported amount | Cadence |
|---|---|---|
| Low arm | 200–250 mcg | daily |
| Mid arm | 500 mcg | daily |
| High arm | 500 mcg | twice daily |
TB-500 (Thymosin Beta-4)
| Study arm | Reported amount | Cadence |
|---|---|---|
| Loading arm | 2–2.5 mg | twice weekly × 4–6 weeks |
| Maintenance arm | 2 mg | weekly |
Practical handling differences
Both arrive lyophilized and shelf-stable. BPC-157 is typically prepared at 5 mg + 2 mL = 2.5 mg/mL (250 mcg = 10 units); TB-500 (Thymosin Beta-4) at 10 mg + 2 mL = 5 mg/mL. Where half-lives differ, the literature's dosing cadence differs accordingly — longer-acting molecules are described weekly, shorter-acting ones daily or split.
Which one appears in which research context
BPC-157 shows up primarily in tissue-repair and gastrointestinal models. TB-500 (Thymosin Beta-4) is used in actin-binding and repair-model research. They are not interchangeable substitutes; the receptor profile, not the marketing category, determines where each is used.
Documentation and sourcing
Both are supplied at ≥99% HPLC purity with lot-level COAs at /coa. Product pages: BPC-157 · TB-500 (Thymosin Beta-4).
How PX1 documents every lot
Every PX1 lot ships with HPLC purity, LC-MS identity, residual solvent, moisture (Karl Fischer), sterility and endotoxin data. Lot documentation is published at /purity-reports, /endotoxin-reports and /coa. Synthesis, purification, lyophilization and vial fill happen in U.S. facilities — see /manufacturing-process.
Research use only. PX1 Research supplies compounds for laboratory and in-vitro research. Nothing here is medical advice, a dosing recommendation, or an offer for human or veterinary use. Figures cited are reported from published laboratory literature.