Epithalon (Epitalon) vs NAD+: Mechanism, Specs & Reported Ranges Compared
Side-by-side comparison of Epithalon (Epitalon) and NAD+ — receptor mechanism, half-life, vial sizes, reconstitution and reported study arms.
By PX1 Research Team · August 4, 2026
Epithalon (Epitalon) vs NAD+ at a glance
| Epithalon (Epitalon) | NAD+ | |
|---|---|---|
| Class | synthetic tetrapeptide (Ala-Glu-Asp-Gly) | nicotinamide adenine dinucleotide cofactor |
| Reported half-life | not well characterized | not well characterized |
| Vial sizes | 10 mg | 100 mg / 500 mg |
| Typical reconstitution | 10 mg + 2 mL = 5 mg/mL | 500 mg + 5 mL = 100 mg/mL |
| Research focus | telomerase and pineal-axis research | sirtuin and NAD-salvage-pathway research |
Mechanistic difference
Epithalon is a telomerase-adjacent tetrapeptide; NAD+ is a metabolic cofactor central to sirtuin activity. Different levels of the longevity-research stack entirely.
Reported study ranges side by side
Epithalon (Epitalon)
| Study arm | Reported amount | Cadence |
|---|---|---|
| Cycle arm | 5–10 mg | daily × 10–20 days |
| Maintenance | 10 mg | 2× yearly cycles |
NAD+
| Study arm | Reported amount | Cadence |
|---|---|---|
| Low arm | 50 mg | daily |
| Mid arm | 100 mg | daily |
| High arm | 250–500 mg | weekly infusion models |
Practical handling differences
Both arrive lyophilized and shelf-stable. Epithalon (Epitalon) is typically prepared at 10 mg + 2 mL = 5 mg/mL; NAD+ at 500 mg + 5 mL = 100 mg/mL. Where half-lives differ, the literature's dosing cadence differs accordingly — longer-acting molecules are described weekly, shorter-acting ones daily or split.
Which one appears in which research context
Epithalon (Epitalon) shows up primarily in telomerase and pineal-axis research. NAD+ is used in sirtuin and NAD-salvage-pathway research. They are not interchangeable substitutes; the receptor profile, not the marketing category, determines where each is used.
Documentation and sourcing
Both are supplied at ≥99% HPLC purity with lot-level COAs at /coa. Product pages: Epithalon (Epitalon) · NAD+.
How PX1 documents every lot
Every PX1 lot ships with HPLC purity, LC-MS identity, residual solvent, moisture (Karl Fischer), sterility and endotoxin data. Lot documentation is published at /purity-reports, /endotoxin-reports and /coa. Synthesis, purification, lyophilization and vial fill happen in U.S. facilities — see /manufacturing-process.
Research use only. PX1 Research supplies compounds for laboratory and in-vitro research. Nothing here is medical advice, a dosing recommendation, or an offer for human or veterinary use. Figures cited are reported from published laboratory literature.