MOTS-c Mitochondrial Derived Peptide: Metabolic Regulation, Exercise Mimetics, and Reconstitution
Laboratory guide for MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c). Explore AMPK activation and metabolic research protocols.
By PX1 Research Team · September 13, 2026
Mechanism: The Mitochondrial-Encoded Hormone
MOTS-c is a unique 16-amino-acid mitochondrial-derived peptide that functions as an exercise mimetic by directly targeting systemic metabolic pathways:
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AMPK Activation: Stimulates AMP-activated protein kinase, promoting intracellular GLUT4 glucose transporter translocation.
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Lipid Oxidation: Enhances metabolic flexibility and reduces intramuscular lipid accumulation.
Handling & Storage Standards
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Reconstitution Diluent: Bacteriostatic Water.
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Temperature: Strict temperature stability must be maintained at 2°C–8°C post-dilution.
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