Sermorelin vs CJC-1295: Mechanism, Specs & Reported Ranges Compared
Side-by-side comparison of Sermorelin and CJC-1295 — receptor mechanism, half-life, vial sizes, reconstitution and reported study arms.
By PX1 Research Team · August 4, 2026
Sermorelin vs CJC-1295 at a glance
| Sermorelin | CJC-1295 | |
|---|---|---|
| Class | GHRH (1-29) fragment | GHRH analog (with or without DAC) |
| Reported half-life | ~10–20 min | ~30 min (no-DAC) / ~6–8 days (DAC) |
| Vial sizes | 5 mg / 10 mg | 5 mg / 10 mg |
| Typical reconstitution | 5 mg + 2 mL = 2.5 mg/mL | 5 mg + 2 mL = 2.5 mg/mL |
| Research focus | endogenous GH-release research | GH-pulse amplitude research |
Mechanistic difference
Sermorelin is the native GHRH(1-29) fragment with a very short half-life; CJC-1295 is a stabilized analog, dramatically extending exposure in DAC form.
Reported study ranges side by side
Sermorelin
| Study arm | Reported amount | Cadence |
|---|---|---|
| Standard arm | 200–500 mcg | nightly |
CJC-1295
| Study arm | Reported amount | Cadence |
|---|---|---|
| No-DAC arm | 100 mcg | 1–3× daily |
| DAC arm | 1–2 mg | weekly |
Practical handling differences
Both arrive lyophilized and shelf-stable. Sermorelin is typically prepared at 5 mg + 2 mL = 2.5 mg/mL; CJC-1295 at 5 mg + 2 mL = 2.5 mg/mL. Where half-lives differ, the literature's dosing cadence differs accordingly — longer-acting molecules are described weekly, shorter-acting ones daily or split.
Which one appears in which research context
Sermorelin shows up primarily in endogenous GH-release research. CJC-1295 is used in GH-pulse amplitude research. They are not interchangeable substitutes; the receptor profile, not the marketing category, determines where each is used.
Documentation and sourcing
Both are supplied at ≥99% HPLC purity with lot-level COAs at /coa. Product pages: Sermorelin · CJC-1295.
How PX1 documents every lot
Every PX1 lot ships with HPLC purity, LC-MS identity, residual solvent, moisture (Karl Fischer), sterility and endotoxin data. Lot documentation is published at /purity-reports, /endotoxin-reports and /coa. Synthesis, purification, lyophilization and vial fill happen in U.S. facilities — see /manufacturing-process.
Research use only. PX1 Research supplies compounds for laboratory and in-vitro research. Nothing here is medical advice, a dosing recommendation, or an offer for human or veterinary use. Figures cited are reported from published laboratory literature.