Survodutide vs Retatrutide (GLP-3): Mechanism, Specs & Reported Ranges Compared
Side-by-side comparison of Survodutide and Retatrutide (GLP-3) — receptor mechanism, half-life, vial sizes, reconstitution and reported study arms.
By PX1 Research Team · August 4, 2026
Survodutide vs Retatrutide (GLP-3) at a glance
| Survodutide | Retatrutide (GLP-3) | |
|---|---|---|
| Class | dual glucagon/GLP-1 receptor agonist | GIP/GLP-1/glucagon triple receptor agonist |
| Reported half-life | ~6 days | ~6 days |
| Vial sizes | 10 mg | 10 mg / 15 mg / 20 mg / 30 mg |
| Typical reconstitution | 10 mg + 2 mL = 5 mg/mL | 10 mg + 2 mL bacteriostatic water = 5 mg/mL |
| Research focus | dual-agonist metabolic research | metabolic and body-composition research |
Mechanistic difference
Both include glucagon receptor activity. Survodutide is a dual GLP-1/glucagon agonist; retatrutide adds GIP on top of that pair.
Reported study ranges side by side
Survodutide
| Study arm | Reported amount | Cadence |
|---|---|---|
| Initiation | 0.6 mg | weekly × 4 |
| Step 1 | 1.2 mg | weekly × 4 |
| Step 2 | 2.4 mg | weekly × 4 |
| Maximal arms | 6 mg | weekly |
Retatrutide (GLP-3)
| Study arm | Reported amount | Cadence |
|---|---|---|
| Initiation | 1 mg | weekly × 4 |
| Step 1 | 2 mg | weekly × 4 |
| Step 2 | 4 mg | weekly × 4 |
| Step 3 | 8 mg | weekly × 4 |
| Maximal arms | 12 mg | weekly |
Practical handling differences
Both arrive lyophilized and shelf-stable. Survodutide is typically prepared at 10 mg + 2 mL = 5 mg/mL; Retatrutide (GLP-3) at 10 mg + 2 mL bacteriostatic water = 5 mg/mL. Where half-lives differ, the literature's dosing cadence differs accordingly — longer-acting molecules are described weekly, shorter-acting ones daily or split.
Which one appears in which research context
Survodutide shows up primarily in dual-agonist metabolic research. Retatrutide (GLP-3) is used in metabolic and body-composition research. They are not interchangeable substitutes; the receptor profile, not the marketing category, determines where each is used.
Documentation and sourcing
Both are supplied at ≥99% HPLC purity with lot-level COAs at /coa. Product pages: Survodutide · Retatrutide (GLP-3).
How PX1 documents every lot
Every PX1 lot ships with HPLC purity, LC-MS identity, residual solvent, moisture (Karl Fischer), sterility and endotoxin data. Lot documentation is published at /purity-reports, /endotoxin-reports and /coa. Synthesis, purification, lyophilization and vial fill happen in U.S. facilities — see /manufacturing-process.
Research use only. PX1 Research supplies compounds for laboratory and in-vitro research. Nothing here is medical advice, a dosing recommendation, or an offer for human or veterinary use. Figures cited are reported from published laboratory literature.