Tesamorelin vs Ipamorelin: Mechanism, Specs & Reported Ranges Compared
Side-by-side comparison of Tesamorelin and Ipamorelin — receptor mechanism, half-life, vial sizes, reconstitution and reported study arms.
By PX1 Research Team · August 4, 2026
Tesamorelin vs Ipamorelin at a glance
| Tesamorelin | Ipamorelin | |
|---|---|---|
| Class | stabilized GHRH analog | selective ghrelin receptor (GHS-R) agonist |
| Reported half-life | ~26–38 min | ~2 hours |
| Vial sizes | 10 mg | 5 mg / 10 mg |
| Typical reconstitution | 10 mg + 2 mL = 5 mg/mL | 10 mg + 2 mL = 5 mg/mL |
| Research focus | GHRH-axis and visceral-adipose research | growth-hormone secretagogue research |
Mechanistic difference
Tesamorelin acts at the GHRH receptor and ipamorelin at the ghrelin receptor — the standard two-input pairing in GH-axis research.
Reported study ranges side by side
Tesamorelin
| Study arm | Reported amount | Cadence |
|---|---|---|
| Standard arm | 1 mg | daily |
| Extended arm | 2 mg | daily |
Ipamorelin
| Study arm | Reported amount | Cadence |
|---|---|---|
| Standard arm | 200–300 mcg | 1–3× daily |
Practical handling differences
Both arrive lyophilized and shelf-stable. Tesamorelin is typically prepared at 10 mg + 2 mL = 5 mg/mL; Ipamorelin at 10 mg + 2 mL = 5 mg/mL. Where half-lives differ, the literature's dosing cadence differs accordingly — longer-acting molecules are described weekly, shorter-acting ones daily or split.
Which one appears in which research context
Tesamorelin shows up primarily in GHRH-axis and visceral-adipose research. Ipamorelin is used in growth-hormone secretagogue research. They are not interchangeable substitutes; the receptor profile, not the marketing category, determines where each is used.
Documentation and sourcing
Both are supplied at ≥99% HPLC purity with lot-level COAs at /coa. Product pages: Tesamorelin · Ipamorelin.
How PX1 documents every lot
Every PX1 lot ships with HPLC purity, LC-MS identity, residual solvent, moisture (Karl Fischer), sterility and endotoxin data. Lot documentation is published at /purity-reports, /endotoxin-reports and /coa. Synthesis, purification, lyophilization and vial fill happen in U.S. facilities — see /manufacturing-process.
Research use only. PX1 Research supplies compounds for laboratory and in-vitro research. Nothing here is medical advice, a dosing recommendation, or an offer for human or veterinary use. Figures cited are reported from published laboratory literature.