Melanotan 1 COA Lookup: Verify Your Lot Number
PX1 Research provides transparent, lot-specific analytical documentation for all laboratory research compounds. Use this verification guide to locate the lot number on your Melanotan 1 vial, match it directly to our third-party testing database, and interpret the complete chemical validation data prior to initiating in vitro or preclinical experimental protocols.
Quick answer
PX1 Research provides transparent, lot-specific analytical documentation for all laboratory research compounds. Use this verification guide to locate the lot number on your Melanotan 1 vial, match it directly to our third-party testing database, and interpret the complete chemical validation data prior to initiating in vitro or preclinical experimental protocols.
Key takeaways
- [Melanotan](/research-peptides/melanotan-2) 1 (also designated as MT-1 or Afamelanotide) is a synthetic peptide analog of alpha-melanocyte-stimulating hormone (α-MSH).
- Every research compound synthesized and distributed by PX1 Research features an alphanumeric lot number printed on the primary label.
- Accessing analytical documentation for your specific batch is straightforward.
- A standard [Certificate of Analysis](/research-peptides/what-is-a-coa-for-peptides) contains distinct analytical sections designed to confirm chemical identity and purity.
Analytical Rigor in Melanocortin Research Compounds
Melanotan 1 (also designated as MT-1 or Afamelanotide) is a synthetic peptide analog of alpha-melanocyte-stimulating hormone (α-MSH). In scientific literature, it is categorized as a non-selective melanocortin receptor agonist. Preclinical models evaluate Melanotan 1 primarily for its melanocortin activity related to skin pigmentation responses, receptor binding affinity across MC1R through MC5R subtypes, and cellular signaling cascades in melanocytes.
Because structural fidelity directly influences receptor binding kinetics in cellular assays, verifying lot-to-lot consistency is essential for reproducible data. Standardizing experimental outcomes requires strict control over peptide identity, purity percentages, and potential contaminant thresholds. Obtaining a verified certificate of analysis (COA) corresponding to your precise Melanotan 1 10mg research vial guarantees that the compound matches theoretical chemical specifications.
Locating the Lot Number on Your Research Vial
Every research compound synthesized and distributed by PX1 Research features an alphanumeric lot number printed on the primary label. To conduct a melanotan 1 coa lot number lookup, examine the side panel of the vial label where the batch code is permanently stamped alongside the target sequence name and target mass.
The lot number follows a standardized PX1 format (e.g., MT1-202408-01A). Check that the print is fully legible and unmarred before opening the protective flip-off cap. If you manage multiple samples across a project, record this lot number in your laboratory management system alongside your experimental raw data files to maintain chain-of-custody compliance and research traceability.
How to Use the Live PX1 COA Database
Accessing analytical documentation for your specific batch is straightforward. Researchers can cross-reference their vial data directly through the centralized PX1 COA database. This open-access repository houses full-resolution analytical reports for every lot manufactured in our domestic facilities.
To perform a lookup, navigate to the search bar on the COA hub and input the full melanotan 1 coa lot number found on your label. The system will retrieve the matching PDF report generated by an independent, ISO 17025 accredited analytical laboratory. If you need assistance matching older lots or bulk procurement documentation, contact our analytical support team via your account dashboard or explore our wholesale account portal for institution-wide inventory management.
Deconstructing the COA: Header and Product Identification
A standard Certificate of Analysis contains distinct analytical sections designed to confirm chemical identity and purity. The header section identifies the manufacturing parameters, including product name, molecular formula, chemical CAS number, molecular weight, appearance, and lot code.
For Melanotan 1 (Ac-Ser-Tyr-Ser-Met-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2), confirm that the theoretical molecular weight matches the value reported on the certificate (1646.85 g/mol). The physical description should specify a white to off-white lyophilized powder. Any variation in physical state or theoretical mass flags a discrepancy that should be resolved before sample reconstitution.
Interpreting High-Performance Liquid Chromatography (HPLC) Results
High-Performance Liquid Chromatography (HPLC) is the primary method used to determine the chromatographic purity of synthetic peptides. The HPLC report included in the Melanotan 1 COA presents a chromatogram detailing retention time (minutes), peak height (mV), and integrated peak area percentage.
PX1 Research enforces a minimum HPLC purity threshold of ≥98.0% for all catalog compounds. When reviewing the HPLC spectrum, the main peak corresponding to Melanotan 1 should dominate the area trace. Minor secondary peaks represent trace deletion sequences or truncated peptides originating during solid-phase peptide synthesis (SPPS). Total purity is calculated as the area of the primary target peak divided by the sum of all integrated peak areas.
Evaluating Mass Spectrometry (MS) Spectra for Structural Identity
While HPLC measures purity by separating molecular species, Mass Spectrometry (MS) confirms exact molecular identity. The MS section of the Melanotan 1 COA displays the mass-to-charge ratio (m/z) of the ion species generated during electrospray ionization (ESI-MS) or matrix-assisted laser desorption/ionization (MALDI-TOF).
Because Melanotan 1 has a theoretical monoisotopic mass of 1645.85 Da, the mass spectrum typically displays multiply charged species such as [M+2H]2+ or [M+3H]3+, alongside the singly protonated [M+H]+ parent ion peak. A lot is validated only when the observed molecular mass matches the theoretical calculated mass within acceptable instrument tolerance (typically ±1.0 Da).
Endotoxin Testing and Bioburden Verification
Bacterial endotoxins (lipopolysaccharides) can confound cell culture assays and in vitro physiological studies by eliciting non-specific inflammatory signaling pathways. Consequently, PX1 Research subjects all peptide production lots to Limulus Amebocyte Lysate (LAL) testing in accordance with USP <85> guidelines.
The COA outlines the measured endotoxin concentration, expressed in Endotoxin Units per milligram (EU/mg). Standard PX1 quality thresholds mandate endotoxin levels below 0.1 EU/mg, ensuring that observed cellular responses in research models are attributable solely to the target melanocortin agonist rather than pyrogenic contaminants.
Comparing Melanotan 1 to Related Melanocortin Compounds
When designing comparative melanocortin binding studies, investigators frequently compare Melanotan 1 against structural analogs within the same class. Researchers evaluating melanocortin receptor dynamics can cross-reference our analytical profiles across the full catalog of research peptides.
For instance, while Melanotan 1 acts as a linear peptide analog of α-MSH, Melanotan 2 is a cyclic heptapeptide derivative possessing altered receptor binding selectivity and distinct lipophilicity profiles. Similarly, PT-141 (Bremelanotide) exhibits specific binding preferences across central melanocortin targets in animal models, whereas tripeptide analogs like KPV target downstream anti-inflammatory cascades without activating skin pigmentation pathways. Comparing the COA metrics of these related compounds allows researchers to standardize peptide concentration across multi-variable assays.
Laboratory Reconstitution and Sample Preparation Protocols
Once the melanotan 1 coa lot number has been verified, proper laboratory handling is critical to preserve peptide integrity. Lyophilized Melanotan 1 should be reconstituted using sterile Bacteriostatic Water or standard laboratory buffer solutions depending on the downstream assay requirements.
To calculate exact molarities and solvent ratios for your assays, utilize the interactive PX1 laboratory reconstitution calculator. Avoid aggressive mechanical vortexing during dissolution; gentle swirling prevents peptide shear stress and denaturation. Reconstituted aliquots should be stored at -20°C or -80°C to prevent freeze-thaw degradation over extended experimental timelines.
The PX1 Quality Commitment: ISO-Compliant Domestic Manufacturing
PX1 Research maintains rigid quality assurance standards across every phase of synthesis, purification, and packaging. All compounds are manufactured within domestic USA facilities operating under cGMP-compliant guidelines. Every lot undergoes independent verification by third-party ISO 17025 accredited testing laboratories.
By publishing full lot-level chromatograms, mass spectra, and bioburden assays, PX1 provides the scientific community with reliable research tools. Researchers seeking further technical specifications or historical lot data can explore our expanded peptide research library for chemical literature, solubility parameters, and structural data.
Frequently Asked Questions
Where is the lot number printed on a PX1 Melanotan 1 vial?
The lot number is printed directly on the primary vial label on the side panel beneath the product name and mass specification.
What is the primary target role of Melanotan 1 in research?
Melanotan 1 is a synthetic melanocortin receptor agonist studied in preclinical models for its melanocortin activity related to skin pigmentation responses and melanocyte signaling pathways.
What HPLC purity percentage does PX1 guarantee for Melanotan 1?
PX1 Research guarantees a minimum HPLC chromatographic purity of ≥98.0% for every batch of Melanotan 1.
How do I verify the mass spectrometry data on my Melanotan 1 COA?
Check the MS section of the COA for the observed m/z peaks and confirm that the calculated parent molecular weight matches the theoretical weight of 1646.85 g/mol.
What is the acceptable endotoxin threshold on a PX1 COA?
PX1 enforces an endotoxin threshold of less than 0.1 EU/mg as determined by LAL assay testing.
Can I request historical COAs for archived lot numbers?
Yes, historical lot reports can be accessed by entering the specific lot string into the PX1 online COA lookup tool or contacting our analytical support team.
How should reconstituted Melanotan 1 be stored in the lab?
Reconstituted solutions should be divided into single-use laboratory aliquots and stored at -20°C to -80°C to minimize degradation from repeated freeze-thaw cycles.
Is Melanotan 1 approved for human consumption or clinical use?
No. Melanotan 1 supplied by PX1 Research is strictly designated for laboratory research use only and must not be used for human or veterinary administration.
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All products are sold strictly for laboratory and research use only. Not for human or veterinary use, diagnosis, treatment or consumption. Statements have not been evaluated by the FDA.