If you are seeking pure MOTS-c peptide for sale for laboratory research, PX1 Research provides reference-grade 10 mg lyophilized vials manufactured in the USA. Every lot undergoes rigorous third-party testing—including RP-HPLC purity verification, mass spectrometry identification, and endotoxin testing—backed by downloadable COAs. Orders dispatch same-day M–F from our California and Arizona logistics facilities.
If you are seeking pure MOTS-c peptide for sale for laboratory research, PX1 Research provides reference-grade 10 mg lyophilized vials manufactured in the USA. Every lot undergoes rigorous third-party testing—including RP-HPLC purity verification, mass spectrometry identification, and endotoxin testing—backed by downloadable COAs. Orders dispatch same-day M–F from our California and Arizona logistics facilities.
When purchasing MOTS-c peptide for sale for in vitro or animal research, securing pure, fully characterized material is critical to experimental reproducibility. MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 16-amino-acid mitochondrial-derived peptide involved in metabolic homeostasis, cellular energy regulation, and stress response pathways.
PX1 Research supplies high-purity MOTS-c synthesized in American facilities under strict quality controls. Each batch is paired with an independent third-party Certificate of Analysis (COA) confirming greater than 99% peptide purity by Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) and verifying molecular mass via Electrospray Ionization Mass Spectrometry (ESI-MS).
To protect cellular models from cytotoxic artifacts, our MOTS-c lots undergo mandatory chromogenic LAL testing to ensure endotoxin levels remain below strictly defined thresholds (<0.1 EU/mg). Orders placed before cutoff times ship same-day from domestic centers in California and Arizona, providing rapid, temperature-controlled delivery to academic, biotech, and pharmaceutical laboratories.
MOTS-c is a unique signaling peptide encoded within the mitochondrial genome rather than the nuclear DNA. First identified in 2015, this 16-amino-acid peptide translocates to the nucleus under cellular stress to regulate nuclear gene expression and cellular metabolism.
In preclinical models, research teams investigate MOTS-c primarily for its role in mitochondrial function, metabolic regulation, and exercise-capacity research. Mechanistic studies indicate that MOTS-c activates AMP-activated protein kinase (AMPK), a central regulator of energy balance, independent of cellular AMP/ATP ratios under specific metabolic conditions.
Investigators exploring metabolic disorders, insulin sensitivity pathways, sarcopenia, and cellular senescence frequently buy order 10 mg vials of MOTS-c to evaluate its downstream signaling cascades in skeletal muscle, adipose tissue, and cardiovascular cell lines. To review mechanistic literature and biochemical data, researchers can access the comprehensive PX1 research library.
Evaluating research peptide suppliers requires clear verification metrics to avoid compromised assay results. When screening sources for MOTS-c peptide for sale, scientific procurement officers should verify six essential quality criteria:
- **Purity Verification by RP-HPLC**: Ensure the supplier provides actual chromatographic spectra for the current batch showing single-peak integrity and peptide purity exceeding 98%.
- **Mass Spectrometry Identification**: Confirm molecular weight using ESI-MS or MALDI-TOF data that matches the theoretical mass of MOTS-c (2174.6 Da).
- **Endotoxin Quantification**: Verify that the lot has undergone LAL assay testing with published endotoxin values below 0.1 EU/mg to prevent immune activation in cell cultures or animal models.
- **Domestic Synthesis & Storage**: Confirm the peptide is synthesized and stored under temperature-monitored conditions within the USA to minimize transport degradation.
- **Lot Traceability**: Require a clear lot number printed on the vial label that links directly to the corresponding third-party analytical documentation.
- **Rapid Domestic Logistics**: Choose vendors operating multiple fulfillment hubs to ensure quick transit times and minimize exposure to ambient temperature spikes during transit.
The market for research chemicals contains numerous suppliers operating without adequate quality controls. A primary red flag is any vendor providing generic or non-batch-specific COAs. A legitimate vendor must publish raw analytical reports matching the precise lot number delivered to your laboratory.
Be cautious of vendors making therapeutic, anti-aging, or clinical administration claims. MOTS-c sold for laboratory research is strictly intended for in vitro assays and preclinical animal studies. Vendors promoting human dosing or clinical use operate in violation of regulatory standards and often source under-regulated materials.
Additionally, avoid suppliers that do not publish endotoxin data or those shipping directly from overseas drop-ship locations. Foreign air transit without temperature protection frequently leads to peptide chain degradation, oxidation, or contamination with bacterial endotoxins.
Because MOTS-c contains hydrophobic amino acid residues (sequence: Met-Met-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg), it is prone to aggregation and oxidation if improperly synthesized or stored. Analytical testing is essential to confirm sequence fidelity and sample cleanliness.
RP-HPLC analysis evaluates baseline resolution and peak symmetry to detect shortened peptides, deletion sequences, or unprotecting side-products generated during solid-phase peptide synthesis (SPPS). PX1 Research guarantees that all lots of MOTS-c achieve baseline separation with total impurities well under 1%.
Furthermore, our mass spectrometry protocols verify sequence identity by confirming the monoisotopic mass, while LAL chromogenic assays measure bacterial endotoxins. Researchers inspecting our MOTS-c peptide product page can review complete, unedited spectral reports prior to placing an institutional order.
Proper handling is required to preserve peptide stability and prevent physical degradation. MOTS-c is supplied as a sterile, lyophilized white powder in sealed 10 mg glass vials.
For optimal reconstitution, allow the vial to equilibrate to room temperature before adding a solvent to prevent moisture condensation. Reconstitute using sterile bacteriostatic water or target-appropriate buffer solutions (such as sterile PBS, pH 7.4). Gentle swirling is recommended; aggressive vortexing or shaking should be avoided as it can induce shear stress and protein aggregation.
Once reconstituted, stock solutions should be divided into single-use aliquots using low-binding polypropylene tubes to prevent repeated freeze-thaw cycles. Lyophilized MOTS-c should be stored at -20°C for short-term projects or -80°C for long-term storage. Reconstituted solutions remain stable at 4°C for up to 7 to 10 days, or at -80°C for up to 6 months.
In metabolic and mitochondrial research, MOTS-c is frequently evaluated alongside other mitochondrial-derived peptides and targeted mitochondrial compounds. Understanding their distinct mechanisms helps researchers select the appropriate compound for specific assay models:
- **MOTS-c vs. SS-31**: While MOTS-c acts as a nuclear-translocating signaling peptide involved in AMPK activation and gene expression regulation, SS-31 research peptide targets cardiolipin on the inner mitochondrial membrane to directly optimize electron transport chain efficiency and reduce ROS production.
- **MOTS-c vs. Humanin**: Both are mitochondrial-derived peptides, but Humanin peptide is primarily studied for cytoprotective and anti-apoptotic pathways in neurodegenerative and cardiovascular models, whereas MOTS-c is heavily studied for systemic metabolic regulation and exercise biology.
To compare additional metabolic compounds or explore complementary reagents, explore our full catalog of mitochondrial research peptides.
For high-throughput screening, multi-animal study protocols, or long-term institutional programs, sourcing standardized peptide lots reduces inter-assay variability across study phases.
PX1 Research accommodates university research groups, contract research organizations (CROs), and industrial biotech firms with custom lot sizes, consistent batch manufacturing, and volume-tiered arrangements. All institutional orders receive dedicated account support, prioritized dispatch, and lot reservation options.
To request custom synthesis parameters, specialized vial sizes, or volume fulfillment options for MOTS-c, visit our wholesale peptide ordering portal to consult with a peptide specialist.
When purchasing MOTS-c peptide for sale from PX1 Research, your lab receives reference-grade material engineered for rigorous scientific investigation. Every order ships directly from our domestic logistics centers located in California and Arizona.
What you receive with every order:
- High-purity lyophilized MOTS-c in secure 10 mg glass vials.
- Instant access to lot-specific, downloadable third-party COA reports detailing RP-HPLC purity, mass spectrometry, and endotoxin analysis.
- Same-day dispatch for orders finalized before 3:00 PM PST/MST, Monday through Friday.
- Fully tracked domestic transit in insulated packaging to maintain product stability.
- Dedicated technical customer support to address batch specifications and analytical inquiries.
To review current batch specifications and complete your institutional procurement, navigate directly to our MOTS-c product listing.
Where can I find verified mots-c peptide for sale for research?
You can source verified MOTS-c peptide for sale directly through PX1 Research. We provide 10 mg lyophilized vials synthesized in the USA, paired with independent HPLC, mass spectrometry, and endotoxin testing for every lot.
Is MOTS-c legal to purchase for laboratory research in the US?
Yes. MOTS-c is legal to purchase across the United States for laboratory research, in vitro studies, and preclinical animal models. It is strictly sold for research use only and not for human or clinical applications.
What purity level is required for MOTS-c in published preclinical studies?
Published preclinical studies typically require a minimum peptide purity of 98%. PX1 Research guarantees batch purity exceeding 99% by RP-HPLC to prevent experimental artifacts caused by sequence impurities.
Does PX1 Research supply a lot-specific Certificate of Analysis for MOTS-c?
Yes. Every order of MOTS-c from PX1 Research includes full access to a lot-specific Certificate of Analysis detailing RP-HPLC chromatograms, ESI-MS mass verification, and LAL endotoxin testing.
What is the recommended storage condition for lyophilized MOTS-c vials?
Lyophilized MOTS-c vials should be stored at -20°C for short-term research needs or at -80°C for long-term storage to prevent peptide degradation, moisture absorption, and oxidation.
How fast does PX1 Research ship MOTS-c orders?
Orders placed before 3:00 PM PST/MST Monday through Friday dispatch same-day from our fulfillment facilities in California and Arizona via tracked domestic shipping.
How is MOTS-c reconstituted in a laboratory setting?
MOTS-c is reconstituted under sterile conditions using bacteriostatic water or sterile phosphate-buffered saline (PBS, pH 7.4). The vial should equilibrate to room temperature prior to adding solvent and swirled gently without aggressive shaking.
What is the difference between MOTS-c and other mitochondrial-derived peptides like Humanin?
While both are encoded by mitochondrial DNA, MOTS-c primarily targets metabolic pathways, cellular homeostasis, and AMPK activation, whereas Humanin is studied primarily for its neuroprotective and anti-apoptotic signaling properties.
Are endotoxin tests performed on every batch of MOTS-c?
Yes. Every batch of MOTS-c undergoes chromogenic LAL endotoxin testing to ensure levels remain below 0.1 EU/mg, protecting sensitive cellular cultures from immune activation artifacts.
Can institutional laboratories purchase MOTS-c in bulk quantities?
Yes. PX1 Research offers tiered pricing and custom lot sizes for academic institutions, CROs, and biotech enterprises requiring bulk quantities of MOTS-c peptide.
All products are sold strictly for laboratory and research use only. Not for human or veterinary use, diagnosis, treatment or consumption. Statements have not been evaluated by the FDA.