PX1 Research supplies reference-standard Pinealon (EDR tripeptide) engineered specifically for rigorous in vitro, biochemical, and preclinical research applications. Every lot undergoes strict third-party analytical testing to guarantee maximum identity, purity, and low endotoxin thresholds.
PX1 Research supplies reference-standard Pinealon (EDR tripeptide) engineered specifically for rigorous in vitro, biochemical, and preclinical research applications. Every lot undergoes strict third-party analytical testing to guarantee maximum identity, purity, and low endotoxin thresholds.
High-purity Pinealon for sale is supplied as a lyophilized, research-grade synthetic tripeptide (Glu-Asp-Arg) intended exclusively for in vitro assay systems and preclinical laboratory research. Sourced primarily by neurobiology and epigenetic research facilities, reference-standard Pinealon requires verification via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to guarantee precise chemical identity and structural purity.
When purchasing research-grade Pinealon, institutional investigators require stringent quality control to eliminate variables in cell culture and animal modeling. PX1 Research delivers USA-manufactured research peptides accompanied by lot-specific certificates of analysis (COAs) to support reproducible scientific inquiry across academic, pharmaceutical, and biotechnology laboratories.
Pinealon is a short-chain synthetic peptide comprising three amino acids: L-glutamyl-L-aspartyl-L-arginine (Glu-Asp-Arg or EDR). With a molecular weight of 418.4 g/mol and the molecular formula C15H26N6O8, this ultra-short sequence belongs to the class of peptide bioregulators developed to examine targeted cellular interactions.
Due to its low molecular weight and specific charge distribution, the EDR sequence demonstrates high stability in liquid media and rapid uptake in cellular culture models. In structural biology studies, short-chain tripeptides like Pinealon are evaluated for their capacity to pass through cellular and nuclear membranes without requiring active transport mechanisms.
Preclinical studies suggest that short synthetic peptides exert biological influence through direct interactions with chromatin and specific DNA sequences. In vitro data indicate that Pinealon can penetrate cell nuclei and bind to the promoter regions of target genes, thereby modulating gene expression at the transcriptional level.
Research in neuronal cell lines shows that the EDR tripeptide regulates genes associated with signal transduction, synaptic plasticity, and cellular survival mechanisms. By influencing histone modifications and DNA methylation pathways, Pinealon serves as a valuable model compound for investigating epigenetic control in neurodegenerative and aging-related cellular frameworks.
In vitro assays using primary neuronal cultures and PC12 cell lines demonstrate that Pinealon exposure reduces reactive oxygen species (ROS) accumulation following induced oxidative stress. Preclinical rodent models investigating cerebral ischemia and hypoxia show that administration of the EDR tripeptide correlates with decreased apoptotic cell death in hippocampal and cortical regions.
Furthermore, animal studies focusing on cognitive parameters indicate that Pinealon research models exhibit improved spatial memory retention and restored synaptic function following toxic insults, such as exposure to beta-amyloid fragments or heavy metal ions. These findings support its continued investigation as a neuroprotective agent in structural and functional neurobiology.
To understand the distinct functional profiles within peptide research, investigators frequently compare short-chain synthetic bioregulators against broader polypeptide complexes. Pinealon (EDR) operates as a selective short-chain neuro-bioregulator, whereas Epitalon (Ala-Glu-Asp-Gly) is primarily investigated for its role in pineal gland gene expression and telomerase activity in senescence models. In contrast, complex biological extracts such as Cortexin provide a heterogeneous mixture of neurotrophic factors and neuropeptides derived from central nervous system tissues.
Researchers evaluating target specificity often choose targeted tripeptides like Pinealon over complex extracts to isolate single-pathway signaling mechanisms. Comparative data across these synthetic bioregulator peptides enable scientists to dissect distinct epigenetic responses within the broader catalog of research peptides.
The reliability of preclinical data hinges on the purity and stability of the starting compound. Substandard peptides containing truncated sequences, residual counter-ions, or bacterial endotoxins can introduce significant noise into experimental assays, confounding cellular viability and gene expression data.
PX1 Research enforces strict quality assurance protocols for all compounds. Every batch of Pinealon is synthesized in state-of-the-art, GMP-compliant facilities within the United States. Following synthesis, samples are analyzed by independent ISO 17025 accredited laboratories to confirm physical and chemical specifications prior to distribution.
To ensure uncompromising laboratory standards, each lot of Pinealon undergoes rigorous testing using Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) to confirm a chemical purity profile exceeding 98%. RP-HPLC separates the main peptide peak from minor synthesis side-products, confirming the absence of unreacted amino acids or deleted sequences.
Electrospray Ionization Mass Spectrometry (ESI-MS) is simultaneously utilized to verify the exact molecular mass of the EDR tripeptide (418.4 Da). Additionally, chromogenic Limulus Amebocyte Lysate (LAL) assays are conducted to ensure endotoxin levels remain below stringent research limits (<0.01 EU/mg), preventing non-specific inflammatory responses in delicate cell cultures. Full analytical data are published in the lot-specific HPLC/MS purity verification documentation.
Pinealon is supplied as a sterile, lyophilized white powder to maximize shelf-life and chemical stability during transport. For laboratory reconstitution, researchers typically dissolve the dry peptide cake in sterile, deionized water or standard phosphate-buffered saline (PBS, pH 7.4), depending on the requirements of the downstream assay.
To prevent mechanical shearing or denaturation, the solvent should be gently directed down the inner glass wall of the vial, followed by mild swirling until completely dissolved. Gentle vortexing at low speeds may be employed if necessary. All reconstitution procedures must be executed under aseptic conditions within a certified laminar flow hood to maintain sterility.
Lyophilized Pinealon powder should be stored at -20°C for short-term projects or -80°C for long-term storage, protected from direct light and moisture ingress. Under these conditions, the unconstitutioned peptide retains chemical stability for up to 24 months.
Once reconstituted into aqueous solution, Pinealon should be aliquoted into single-use microcentrifuge tubes to avoid repeated freeze-thaw cycles, which can degrade peptide bonds over time. Reconstituted liquid aliquots should be maintained at 2°C to 8°C for immediate use (within 48 to 72 hours) or stored at -20°C for up to several months.
Securing consistent peptide supplies is critical for maintaining longitudinal research schedules. PX1 Research operates dual fulfillment centers located in California and Arizona, providing fast, dependable shipping with same-day dispatch for orders confirmed Monday through Friday before cut-off times.
For universities, contract research organizations (CROs), and industrial laboratories requiring ongoing material supply, PX1 Research provides fully traceable lot numbers, direct batch-level COA access, and dedicated support for bulk research procurement. Every shipment is packaged under temperature-controlled protocols to protect molecular integrity during transit.
What is Pinealon and what is its primary chemical structure?
Pinealon is a synthetic tripeptide composed of L-glutamyl-L-aspartyl-L-arginine (Glu-Asp-Arg or EDR). It has a molecular weight of 418.4 g/mol and is classified as a short-chain bioregulator studied for its interactions with neuronal gene expression.
Is Pinealon supplied by PX1 Research intended for human consumption?
No. Pinealon supplied by PX1 Research is strictly designated for laboratory research, in vitro assays, and preclinical animal models. It is not for human or veterinary use, medical therapy, or clinical administration.
How does PX1 Research verify the purity of Pinealon?
Every lot of Pinealon undergoes independent third-party testing utilizing RP-HPLC (to confirm >98% purity) and Mass Spectrometry (to verify molecular weight). Certificates of Analysis (COAs) containing raw chromatograms are available for every lot.
What endotoxin levels are acceptable for research-grade Pinealon?
PX1 Research enforces strict endotoxin controls, testing every batch via chromogenic LAL assays to ensure endotoxin content remains below 0.01 EU/mg, preventing cellular toxicity during sensitive in vitro assays.
How should lyophilized Pinealon be stored upon arrival?
Upon receipt, lyophilized Pinealon should be stored in a freezer at -20°C or -80°C, kept away from light and moisture. Desiccant packs can be utilized to prevent condensation inside storage containers.
What diluents are recommended for reconstituting Pinealon?
Pinealon is readily soluble in sterile bacteriostatic water, sterile normal saline (0.9% NaCl), or standard laboratory buffers such as PBS (pH 7.4), depending on specific experimental design constraints.
How does Pinealon differ from Epitalon?
Pinealon is an EDR tripeptide studied primarily for central nervous system gene expression and oxidative stress reduction in neuronal models. Epitalon is an AEDG tetrapeptide focused on pineal regulation, melatonin synthesis, and telomerase activity.
Where is PX1 Research Pinealon manufactured and shipped from?
All PX1 Research peptides are synthesized in USA-based, GMP-compliant facilities and dispatched from fulfillment hubs in California and Arizona with same-day shipping available Monday through Friday.
All products are sold strictly for laboratory and research use only. Not for human or veterinary use, diagnosis, treatment or consumption. Statements have not been evaluated by the FDA.